Annotation Detail for TRPM7
Basic Information
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| Gene Symbol: | TRPM7 ( CHAK,CHAK1,FLJ20117,FLJ25718,LTRPC7,TRP-PLIK ) |
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| Gene Full Name: | transient receptor potential cation channel, subfamily M, member 7 |
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| Band: | 15q21.2 |
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| Quick Links | Entrez ID:54822; OMIM: 605692; Uniprot ID:TRPM7_HUMAN; ENSEMBL ID: ENSG00000092439; HGNC ID: 17994 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Desease Name |
|---|
| Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1, susceptibility to |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of TRPM7 mRNA | affects expression | 16483693
|
| C002791 |
bismuth tripotassium dicitrate |
bismuth tripotassium dicitrate results in decreased expression of TRPM7 mRNA | decreases expression | 15912405
|
| D002136 |
Calcium, Dietary |
TRPM7 gene polymorphism affects the susceptibility to [Magnesium co-treated with Calcium, Dietary] | affects cotreatment|affects response to substance | 17823441
|
| C071834 |
glycidamide |
glycidamide results in increased expression of TRPM7 mRNA | increases expression | 17822822
|
| D008274 |
Magnesium |
TRPM7 gene polymorphism affects the susceptibility to [Magnesium co-treated with Calcium, Dietary] | affects cotreatment|affects response to substance | 17823441
|
| D008345 |
Manganese |
TRPM7 protein results in increased uptake of Manganese | increases uptake | 16428268
|
| C006253 |
pirinixic acid |
pirinixic acid results in increased expression of TRPM7 mRNA | increases expression | 12832660
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
3.95 | 18287403 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.42 | 18653653 |
| MESH:D000236 |
Adenoma |
marker/mechanism |
|
| 17823441 |
| MESH:D000236 |
Adenoma |
|
Magnesium |
4.69 | 17823441 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
3.88 | 16434500 |
| OMIM:105500 |
AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM/DEMENTIA COMPLEX 1 |
marker/mechanism |
|
| |
| MESH:D000756 |
Anemia, Sideroblastic |
|
Manganese |
5.15 | 16910769 |
| MESH:D001321 |
Autistic Disorder |
|
Magnesium |
3.57 | 16846101 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.43 | 19483382 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.03 | 19176532 |
| MESH:D003110 |
Colonic Neoplasms |
|
Calcium, Dietary |
4.26 | 17182828 |
| MESH:D003111 |
Colonic Polyps |
marker/mechanism |
|
| 17823441 |
| MESH:D003111 |
Colonic Polyps |
|
Magnesium |
6.38 | 17823441 |
| MESH:D015179 |
Colorectal Neoplasms |
marker/mechanism |
|
| 17823441 |
| MESH:D015179 |
Colorectal Neoplasms |
|
Magnesium |
3.45 | 17823441 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.53 | 18249437 |
| MESH:D002658 |
Developmental Disabilities |
|
Magnesium |
5.08 | 16846101 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.76 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.04 | 19236843 20131406 |
| MESH:D005909 |
Glioblastoma |
|
Manganese |
4.08 | 17043766 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.69 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.35 | 19176532 19772884 16221962 18467677 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.45 | 20558911 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.80 | 16306350 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.90 | 20007298 16377806 15890375 |
| MESH:D008275 |
Magnesium Deficiency |
|
Magnesium |
6.84 | 17823441 |
| MESH:D020149 |
Manganese Poisoning |
|
Manganese |
5.96 | 16568477 16551646 19453300 |
| MESH:D008881 |
Migraine Disorders |
|
Magnesium |
4.96 | 18803445 |
| MESH:D009069 |
Movement Disorders |
|
Manganese |
5.31 | 16551646 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.86 | 16239165 |
| MESH:D009190 |
Myelodysplastic Syndromes |
marker/mechanism |
|
| 18575777 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.24 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.16 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.06 | 17405874 |
| MESH:D009410 |
Nerve Degeneration |
|
Manganese |
4.48 | 16551646 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.86 | 20558911 |
| MESH:D010300 |
Parkinson Disease |
|
Manganese |
3.45 | 11181820 |
| MESH:D020734 |
Parkinsonian Disorders |
|
Manganese |
4.73 | 16140633 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.50 | 19058328 |
| Pathway ID |
Pathway Name |
|---|
| KEGG:04978 |
Mineral absorption |
PharmGKB Accession:PA38273
| Releated drug ID |
Related drug Name |
| PA450626 | nicotine |
| Drugbank ID |
Action |
Drug Name |
Description |
|---|
| DB03431 |
- |
Adenosine-5'-Diphosphate |
|
| DB04395 |
- |
Phosphoaminophosphonic Acid-Adenylate Ester |
|
| DB04447 |
- |
1,4-Dithiothreitol |
|
Related Pathway Information