AutismKB 2.0

Annotation Detail for BSPRY


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Basic Information Top
Gene Symbol:BSPRY ( FLJ20150 )
Gene Full Name: B-box and SPRY domain containing
Band: 9q32
Quick LinksEntrez ID:54836; OMIM: NA; Uniprot ID:BSPRY_HUMAN; ENSEMBL ID: ENSG00000119411; HGNC ID: 18232
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of BSPRY mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of BSPRY mRNAaffects expression 21346803
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of BSPRY mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of BSPRY mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BSPRY mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BSPRY mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BSPRY mRNAaffects cotreatment|increases expression 18164116
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of BSPRY mRNAincreases expression 18242016
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of BSPRY mRNAincreases expression 17557909
D005419 Flavonoids Flavonoids results in decreased expression of BSPRY mRNAdecreases expression 18035473
D010081 Oxazolone Oxazolone results in increased expression of BSPRY mRNAincreases expression 18242016
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in increased expression of BSPRY mRNAincreases expression 18242016
D014303 Trinitrotoluene Trinitrotoluene affects the expression of BSPRY mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 15.367525203
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 15.367525203
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 15.367525203
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.0319389873
MESH:D000236 Adenoma Diethylnitrosamine 7.036695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0217162532 19052882 16434500 19061943 18056438 17620307
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 3.5211467998 20032816 17015710 16792590 15590891 15855793 15590890 12684321 170078 16210060 11742282 10797510 3040596 8156442 10934080 6091945 11077013 6091946 12762349 19187332 7684630 12585506 18394133
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.5917474063
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 2.5911921183
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.6015590891 12507178 8156442
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6416935385 19383236 19539802 16540662 16569478 19107877 16288022 17428255 19171122 16830150 21159647 20935162 16779866 20512989 20727157 20101231 20524982 17162532 19052882 20007298 3084413 18494052 18210153 16698587 18506893 18978308 17761372 19519916 19822196 20084675 19208518 19394651 19701751 19335982 17978847 3581430 17138121 18785209 20214788 16807293 17173139 18691550 18393292 19418558 11831363 16878318 18056438 10737359 16328049 16502159 10672840 20514400 16681979 18665156 18971187 19919837 20432363 17055752 18788625
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 8.0514694615
MESH:D002386 Cataract Trinitrotoluene 8.0515817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.886135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.887505956 2727394 21159647 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9311677210 17333356 17681005 17110522 16105132 15861022 16919318
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.8817373747 19159591
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 16.3215095906
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 16.3215095906
MESH:D000013 Congenital Abnormalities Trinitrotoluene 16.3215095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 19.4418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 19.4418551238
MESH:D003490 Cyanosis Trinitrotoluene 19.4418551238
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 8.1615491423
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 8.1618759878 15491423 12956900
MESH:D003877 Dermatitis, Contact Oxazolone 10.4812811023 15944321
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 10.4817010967
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.6021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.6018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 15.6021346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.6021346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.6019107877
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 15.6018551238 21346803
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.758156442
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.8618447907
MESH:D005234 Fatty Liver Diethylnitrosamine 7.9721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9715345470
MESH:D006529 Hepatomegaly Trinitrotoluene 4.3415817613
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.6811019492 10880147
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0717937319
MESH:D007248 Infertility, Male Trinitrotoluene 7.0712150543
MESH:D007249 Inflammation Diethylnitrosamine 5.3218785209
MESH:D007249 Inflammation Flavonoids 5.3217296493
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5916705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8719638242 18522880 18407596 20032147 18665156
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1217034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.687678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.6821295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.6820501860 15175105 18978307 12771043 18648771 19690152 19642983 19812893 20118626 21278145 2862719 20137499 19090486 18644402 21071580 19426721 20101389 12112319 2422723 19073162 19551842 19427195 20434301 19499222 9163691 18754104 19996281 20452335 19833225 19254457 19256749 19638242 19255062 19294768 20583210 18977376 15885732 16942905 20405173 21167192 10737359 20492335 21047994 19850985
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.216135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.2118164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.2117174075 18544905 19539802 18079962 19519916 19126423 16267830 18775883 19009564 18253720 2563599 18164116 9362446 17854601 19004024 18093689 18282651 16842330 18308698 21159647 17942915 3124819
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 20970405 6695378 21163286
MESH:D008545 Melanoma Dinitrochlorobenzene 3.2012202904 17334785
MESH:D009336 Necrosis 2,4-dinitrotoluene 18.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 18.507678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 18.5018551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.841670384
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 29.1916049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 29.1916049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 29.1914694615
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 29.1912585506 11077013 6091946 3040596 8156442 18394133 6091945
MESH:D009784 Occupational Diseases Trinitrotoluene 29.1914694615 17852074 12819281
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.7614606601
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.4820219652 7692837 16940033
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 5.2518447907
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.6619050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.4115015336 12617775
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.6419075512
MESH:D012640 Seizures 2,4-dinitrotoluene 10.2418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.2418551238
MESH:D012640 Seizures Trinitrotoluene 10.2418551238
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.6419050374 19075512
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013163 Splenomegaly Trinitrotoluene 5.3015817613
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.047505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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