AutismKB 2.0

Annotation Detail for SYTL2


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Basic Information Top
Gene Symbol:SYTL2 ( CHR11SYT,EXO4,FLJ21219,FLJ34802,FLJ42764,FLJ45597,KIAA1597,MGC102768,SGA72M,SLP2,SLP2A )
Gene Full Name: synaptotagmin-like 2
Band: 11q14.1
Quick LinksEntrez ID:54843; OMIM: 612880; Uniprot ID:SYTL2_HUMAN; ENSEMBL ID: ENSG00000137501; HGNC ID: 15585
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SYTL2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SYTL2 mRNAincreases expression 18648102
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SYTL2 mRNAaffects expression 17555576
D005472 Fluorouracil Fluorouracil results in increased expression of SYTL2 mRNAincreases expression 16510598
D008942 Mitoxantrone SYTL2 mRNA affects the susceptibility to Mitoxantroneaffects response to substance 16044152
D013629 Tamoxifen Tamoxifen affects the expression of SYTL2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5514692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.5517638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D000740 Anemia Fluorouracil 4.0215504547 17963324 16511603
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001943 Breast Neoplasms Fluorouracil 2.2116110121 16595493 18357371 16557594 18608205 15136595 19217205
MESH:D001943 Breast Neoplasms Tamoxifen 2.2120544844 21152245 17893378 20135344 19221464 17440819 18815881 19066611 19189210 16818667 15565566 18629630 20390343 19244106 19410462 19103187 19011961 18351453 21138602 18855134 19115204 20859285 11161223 18997820 17261762 18821012 19288272 19200415 19189212 18984771 19084267 19142967 15668708 19289846 18425577 20065188 20005174 16273361 16873071 16202921 19059307 17049068 19155303 17242785 19487384
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.917296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.9117045692 17088986 16799960 17971768 16332177 18930000
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.9116924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.927296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.9218695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5618986760 16757204 17066447 16280240
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.649022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.6417333356 11677210 17110522 16919318 15861022 16105132 17681005
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717725105 17287894 17018589 16340194 17016597 17172411 18772588 17169374 15001691 16510598
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018448328 15289873 18802399 18288408 20501625 18949393 16391804 16303861 16524972 17594712 17401013 18383874 17454858 17255274 17695437 17094418 18509181 14970324 15148649 16282729 16331619 17016601
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2111298694 2524372 18759878 11906362 8970840 14531868 12868966 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.1021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.1018692083 16192314 8291058 7440962 9653073 9328219 6482804 6679447 18648102 1440618 9022650 11289319 18289764
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2417893378 19155303 20544844 16202921
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.743581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7417638652 15173087 16337965 16481741 16785472
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.7915345470
MESH:D005234 Fatty Liver Tamoxifen 8.7914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5918337622 15102660 15162350
MESH:D006331 Heart Diseases Mitoxantrone 4.3616019553
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tamoxifen 2.4919457130
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 20.0916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 20.096582329
MESH:D007680 Kidney Neoplasms Fluorouracil 20.0916985049
MESH:D007680 Kidney Neoplasms Tamoxifen 20.0918625569
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.9018172266
MESH:D008064 Lipidoses Tamoxifen 3.3715342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Fluorouracil 5.0118383874 15113037 17045692 16603448
MESH:D008113 Liver Neoplasms Tamoxifen 5.0116684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.71598648 3712494 1399818 6587162
MESH:D008175 Lung Neoplasms Fluorouracil 2.6015246190
MESH:D008175 Lung Neoplasms Tamoxifen 2.6018625569
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8111731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8716757204 18986760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.053581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.0519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms Fluorouracil 5.9818600527 16928823 18239605
MESH:D009369 Neoplasms Mitoxantrone 5.9816640825
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219200415 19189210 19196722
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9112819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.916482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7515113037 16929163 19003803 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2319082440 18626508
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3015538739 18722050 18286688 16160472
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018567086 17498489 16951190 17172411 19015929 15786421 18396642 17522103 19084572 16424979
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.127505956 6582329 1399818 3712494 6587162
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.9016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.908074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.9016712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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