AutismKB 2.0

Annotation Detail for FBXL12


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Basic Information Top
Gene Symbol:FBXL12 ( FLJ20188,Fbl12 )
Gene Full Name: F-box and leucine-rich repeat protein 12
Band: 19p13.2
Quick LinksEntrez ID:54850; OMIM: 609079; Uniprot ID:FXL12_HUMAN; ENSEMBL ID: ENSG00000127452; HGNC ID: 13611
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001194 Asbestos Asbestos affects the expression of FBXL12 mRNAaffects expression 17297452
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FBXL12 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of FBXL12 mRNAdecreases expression 17942748
D009532 Nickel MT1 affects the reaction [Nickel affects the expression of FBXL12 mRNA]affects expression|affects reaction 16166738
D009532 Nickel MT2 affects the reaction [Nickel affects the expression of FBXL12 mRNA]affects expression|affects reaction 16166738
D018038 Sodium Selenite Sodium Selenite results in increased expression of FBXL12 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of FBXL12 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D055371 Acute Lung Injury Nickel 4.9916166738
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D050197 Atherosclerosis Asbestos 4.4118795166
MESH:D001943 Breast Neoplasms Nickel 2.5115986119
MESH:D001943 Breast Neoplasms Tamoxifen 2.5119288272 19142967 18997820 15565566 17049068 19221464 18821012 21138602 19103187 19011961 21152245 19189210 17261762 19189212 19200415 17893378 19066611 20544844 19487384 18351453 20390343 20135344 18984771 18855134 20005174 11161223 18425577 16202921 20065188 15668708 17440819 19115204 20859285 18815881 16818667 19410462 19289846 19084267 17242785 16273361 16873071 19244106 19059307 19155303 18629630
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1317681005 15861022 16105132 11677210 16919318 17333356 17110522
MESH:D019457 Chromosome Breakage Sodium Selenite 5.2415894690
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.4219470301 17100760 17244072
MESH:D003877 Dermatitis, Contact Nickel 5.042952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1016285004
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.3615131321
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2616202921 20544844 17893378 19155303
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.9615345470
MESH:D005234 Fatty Liver Tamoxifen 8.9614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D015658 HIV Infections Nickel 3.9817263646
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Nickel 6.0116166738
MESH:D007249 Inflammation Tamoxifen 6.0119457130
MESH:D007333 Insulin Resistance Sodium Selenite 3.4914714311
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3518625569
MESH:D008064 Lipidoses Tamoxifen 3.4015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3216684651
MESH:D008175 Lung Neoplasms Asbestos 3.0412111688
MESH:D008175 Lung Neoplasms Tamoxifen 3.0418625569
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4614737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8314580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008654 Mesothelioma Asbestos 4.2018310086 16319530 18709470 16564556 16919927
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119189210 19200415 19196722
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2118760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4617572228 16712894 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9115869587 14671159
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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