AutismKB 2.0

Annotation Detail for SNRK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SNRK ( DKFZp779A1866,FLJ20224,HSNFRK,KIAA0096 )
Gene Full Name: SNF related kinase
Band: 3p22.1
Quick LinksEntrez ID:54861; OMIM: 612760; Uniprot ID:SNRK_HUMAN; ENSEMBL ID: ENSG00000163788; HGNC ID: 30598
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of SNRK mRNAincreases expression 19643169
D000082 Acetaminophen Acetaminophen affects the expression of SNRK mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SNRK mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SNRK mRNAdecreases expression 20498004
D002117 Calcitriol Calcitriol results in increased expression of SNRK mRNAincreases expression 16002434
D004958 Estradiol Estradiol affects the expression of SNRK mRNAaffects expression 15598610
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SNRK mRNAaffects cotreatment|increases expression 17942748
C005219 methyl cellosolve methyl cellosolve results in increased expression of SNRK mRNAincreases expression 19643169
D005996 Nitroglycerin Nitroglycerin results in increased expression of SNRK mRNAincreases expression 12102619
D010126 Ozone Ozone results in decreased expression of SNRK mRNAdecreases expression 12763052
C006253 pirinixic acid pirinixic acid results in increased expression of SNRK mRNAincreases expression 18301758
17426115
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SNRK mRNAaffects cotreatment|increases expression 17942748
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of SNRK mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 15.246499820 6499796 6499812 7151721 6499823
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 15.246474471 6499812 3652986
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.2414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 11.0218287403
MESH:D000138 Acidosis Zinc Sulfate 11.027265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.1211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1214692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.483699323
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D000860 Anoxia Zinc Sulfate 5.137265320
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 13.0010689203 6499807 6499823
MESH:D053627 Asthenozoospermia methyl cellosolve 13.003987992
MESH:D001249 Asthma Ozone 2.6617854713 16373670
MESH:D001259 Ataxia 2-ethoxyethanol 5.547151721
MESH:D001284 Atrophy 2-ethoxyethanol 11.7315850284 6499799
MESH:D001284 Atrophy methyl cellosolve 11.733699323 2626667 6705890
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D053713 Azoospermia 2-ethoxyethanol 5.686492198 6499807
MESH:D001724 Birth Weight 2-ethoxyethanol 6.656499823 2884743
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes 2-ethoxyethanol 12.487151721 6499796
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 12.4815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9417474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 1.9411237771
MESH:D001943 Breast Neoplasms Estradiol 1.9419861407 16675129 14630087 12948864 17018787 17289903 17261762 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7418417511 17626835 18315731 19059883 15516495 14754758 16777450
MESH:D002100 Cachexia Ozone 4.8616183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.853084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.8516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.7611237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8218566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002764 Cholecystitis 2-ethoxyethanol 14.116499794
MESH:D002764 Cholecystitis methyl cellosolve 14.116499794
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9417333356 16105132 15861022 17681005 11677210 16919318 17110522
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 12621046 16354765 15668235 8697196
MESH:D000013 Congenital Abnormalities methyl cellosolve 9.6712530607 6499821
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.6717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003643 Death 2-ethoxyethanol 6.106499796
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.6314986274 18071297 11743745 11287661 16393943 16781746 15968718 10663392 14550746 19739265 11834606 10915739 19420014 14725611 16227642 18713872 12540782 19416960 11421492 12705907 2444490 17906064 12594235 16081117 19085960 16109766 17522070 11461765 17562736 19370779 15619225 11529661 16177239 16485898 19164858 12958197 12392966 19923254 12153990 10774834 11739529
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 16714409 15322242
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.656499796
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.4115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4112538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0311473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8215345470
MESH:D005234 Fatty Liver pirinixic acid 7.8219236843 20131406
MESH:D005313 Fetal Death 2-ethoxyethanol 11.197151721 2884743 7198755 6499820 6499823
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 11.1911858732
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.516499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 13.136499820 6499812
MESH:D005327 Fetal Resorption methyl cellosolve 13.136499812 6474471 3987992 6499821
MESH:D020567 Fetal Weight 2-ethoxyethanol 14.117151721 2884743 6499820
MESH:D020567 Fetal Weight methyl cellosolve 14.116474471 6499812 6499821
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.573652986
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006261 Headache Nitroglycerin 5.3211284996 11554966
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.906499821
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 5.4720172899 10514026
MESH:D006461 Hemolysis 2-ethoxyethanol 12.7917874071 19051582
MESH:D006461 Hemolysis methyl cellosolve 12.7917874071
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 5.1017063115
MESH:D006529 Hepatomegaly pirinixic acid 8.6116221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007022 Hypotension Zinc Sulfate 4.567265320
MESH:D007247 Infertility, Female 2-ethoxyethanol 10.696499823
MESH:D007247 Infertility, Female Ethinyl Estradiol 10.6912013081
MESH:D007248 Infertility, Male 2-ethoxyethanol 11.846499823
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.8417937319
MESH:D007248 Infertility, Male methyl cellosolve 11.843987992
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.3716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.0315629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.0315618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0515610895
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.3315237267
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 4.556499821
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4212878042
MESH:D008107 Liver Diseases Acetaminophen 1.6511587558 16611625 12587719 12969438 19014921 19784758 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4820195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.4815890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008171 Lung Diseases Ozone 3.438266340 19066396
MESH:D055370 Lung Injury Ozone 3.9520417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4418569708 20464547 6695378 20869020 20135361 17053015 18816296 20064080 18520028
MESH:D008175 Lung Neoplasms Ozone 3.447614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4411884234 19555203
MESH:D008231 Lymphopenia methyl cellosolve 5.903699323
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6111408345 16891317 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008679 Metaplasia Ozone 5.2410496685
MESH:D008708 Methemoglobinemia Nitroglycerin 4.823537620
MESH:D020326 Migraine without Aura Nitroglycerin 5.2214659530
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction Nitroglycerin 6.1214729435
MESH:D009203 Myocardial Infarction pirinixic acid 6.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.4616411023
MESH:D009336 Necrosis 2-ethoxyethanol 5.4620172899
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9511141357
MESH:D009369 Neoplasms pirinixic acid 4.9517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Estradiol 9.7811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009845 Oligospermia 2-ethoxyethanol 11.7720172899
MESH:D009845 Oligospermia methyl cellosolve 11.773987992
MESH:D010051 Ovarian Neoplasms Estradiol 2.2419401270
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010538 Peritonitis Ozone 4.2316369182
MESH:D011014 Pneumonia Ozone 4.5118929643 18007984 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 17.277198755 2884743 6499817
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 17.276499817 12530607 7974496
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.2711118676 11399792 11896295 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.5416644109 15754350 12479363 18247401 16289102
MESH:D011471 Prostatic Neoplasms Estradiol 2.5416740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5910029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 4.466499799
MESH:D013733 Testicular Diseases 2-ethoxyethanol 11.466499806 10514026 10048760
MESH:D013733 Testicular Diseases methyl cellosolve 11.466499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved