AutismKB 2.0

Annotation Detail for QRICH1


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Basic Information Top
Gene Symbol:QRICH1 ( FLJ20259,MGC131838 )
Gene Full Name: glutamine-rich 1
Band: 3p21.31
Quick LinksEntrez ID:54870; OMIM: NA; Uniprot ID:QRIC1_HUMAN; ENSEMBL ID: ENSG00000198218; HGNC ID: 24713
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of QRICH1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of QRICH1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of QRICH1 mRNAdecreases expression 19150397
D019833 Genistein Genistein inhibits the reaction [Nocodazole results in increased phosphorylation of QRICH1 protein]decreases reaction|increases phosphorylation 17510977
D015739 Nocodazole Genistein inhibits the reaction [Nocodazole results in increased phosphorylation of QRICH1 protein]decreases reaction|increases phosphorylation 17510977
D015739 Nocodazole Nocodazole results in increased phosphorylation of QRICH1 proteinincreases phosphorylation 17510977
D017239 Paclitaxel Paclitaxel results in increased phosphorylation of QRICH1 proteinincreases phosphorylation 17510977
D014747 Vinblastine Vinblastine results in increased phosphorylation of QRICH1 proteinincreases phosphorylation 17510977
D014750 Vincristine Vincristine results in increased phosphorylation of QRICH1 proteinincreases phosphorylation 17510977
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Genistein 5.2511473722
MESH:D000230 Adenocarcinoma Vincristine 5.2519825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001859 Bone Neoplasms Paclitaxel 4.8315867366
MESH:D001943 Breast Neoplasms Genistein 2.5017200150 16541309 16873071
MESH:D001943 Breast Neoplasms Paclitaxel 2.5016115903 16273361 11325840 15136595 18323546 16244791 18223236 18234424
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.863581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.863084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.8616924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 6.8616313753
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 11.627296757
MESH:D002292 Carcinoma, Renal Cell Vinblastine 11.621485588
MESH:D002292 Carcinoma, Renal Cell Vincristine 11.6216201981
MESH:D002294 Carcinoma, Squamous Cell Vincristine 3.886189445
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.187505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3219486331 9022650
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.0918802399
MESH:D015179 Colorectal Neoplasms Vinblastine 3.0918802399
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.102524372 11906362 8156756 8970840 14531868 11298694 12868966 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5316647724
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.916482804 18289764 7440962 1440618 18648102 9328219 11289319 9022650 18692083 16192314 6679447 8291058 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9116393943 17522070 12705907 11421492 12392966 12958197 17562736 19416960 10774834 14725611 14550746 19923254 11287661 11834606 11529661 16781746 19370779 19085960 10915739 2444490 12540782 15619225 10663392 14986274 11739529 19739265 12153990 16177239 11743745 12594235 18713872 19164858 18071297 15968718 16485898 16081117 17906064 19420014 16109766 16227642 11461765
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.613581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6120426865
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.6116481741
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006689 Hodgkin Disease Vinblastine 8.9618180244 18501091
MESH:D006689 Hodgkin Disease Vincristine 8.9616794504 15147373 17606976 16135485
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.176582329
MESH:D007938 Leukemia Genistein 3.1317468513 18980019
MESH:D008080 Liposarcoma Paclitaxel 5.0817353645
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 16610002 19460945 12587719 19014921 11587558 12969438 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.676587162 3712494 1399818 598648
MESH:D008175 Lung Neoplasms Vincristine 3.3419825857 6189445
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2914749477
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0812929590 14578162
MESH:D008545 Melanoma Paclitaxel 4.0116342250 12025231 12040289
MESH:D008545 Melanoma Vinblastine 4.0116809738 18332650 18176117 16248763 15577320 15577323 12374674 17761969 16432458 18505091
MESH:D018328 Melanoma, Amelanotic Vincristine 6.1215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009101 Multiple Myeloma Paclitaxel 3.8514749477
MESH:D009203 Myocardial Infarction Genistein 6.7017141266
MESH:D009203 Myocardial Infarction Vincristine 6.7017284715
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.233581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.2315867366
MESH:D009421 Nervous System Malformations Genistein 4.3116427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D017599 Neuroectodermal Tumors Vincristine 6.0412837982
MESH:D009503 Neutropenia Vinblastine 4.8317378895
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010014 Osteolysis Paclitaxel 5.3215867366
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010051 Ovarian Neoplasms Genistein 5.3919005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.3911161223
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 4.7421297632
MESH:D011471 Prostatic Neoplasms Genistein 3.5215256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.5216729912 17172428 17136230 16356831
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4418396642 18506536
MESH:D015173 Supratentorial Neoplasms Vincristine 6.2112837982
MESH:D024801 Tauopathies Paclitaxel 5.1516930453
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.067505956 1399818 3712494 6587162 6582329
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.358074119
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014625 Vaginal Neoplasms Vinblastine 5.3515577323
Pathway ID Pathway Name
KEGG:00970 Aminoacyl-tRNA biosynthesis
KEGG:01100 Metabolic pathways
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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