AutismKB 2.0

Annotation Detail for RETSAT


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Basic Information Top
Gene Symbol:RETSAT ( FLJ20296 )
Gene Full Name: retinol saturase (all-trans-retinol 13,14-reductase)
Band: 2p11.2
Quick LinksEntrez ID:54884; OMIM: NA; Uniprot ID:RETST_HUMAN; ENSEMBL ID: ENSG00000042445; HGNC ID: 25991
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RETSAT proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RETSAT mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RETSAT mRNAincreases expression 20106945
D020122 tert-Butylhydroperoxide RETSAT protein results in increased susceptibility to tert-Butylhydroperoxideincreases response to substance 17664141
D002104 Cadmium Cadmium results in increased expression of RETSAT mRNAincreases expression 17327699
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of RETSAT mRNAincreases expression 17327699
D002995 Clofibric Acid Clofibric Acid affects the expression of RETSAT mRNAaffects expression 17602206
D011345 Fenofibrate Fenofibrate results in increased expression of RETSAT mRNAincreases expression 11798191
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of RETSAT mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of RETSAT mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of RETSAT mRNAincreases expression 11798191
17426115
D014284 Triiodothyronine Triiodothyronine results in increased expression of RETSAT mRNAincreases expression 15953391
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RETSAT mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RETSAT mRNAincreases expression 16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RETSAT mRNAincreases expression 18796159
16960034
15644576
D014212 Tretinoin RETSAT protein results in increased oxidation of Tretinoinincreases oxidation 17253779
C024366 vitamin A2 RETSAT protein results in increased oxidation of vitamin A2increases oxidation 17253779
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5714514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.7917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.7916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.7916835633
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D050197 Atherosclerosis Cadmium 3.6715687053
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.6019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.6012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.6016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8020146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6712619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.6720007298 6705139 1701930 20935162 17173139
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.671917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6220419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6216096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 3.7317332340
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.324080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis pirinixic acid 2.8619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8316354765 8697196 15340226 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 5.839407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4610048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4614991402 9142499 9664655 9211117 10589399 9224671 9125849 16925845 8800419 17551590
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D050171 Dyslipidemias Fenofibrate 4.4616707586
MESH:D004421 Dystonia Phenobarbital 4.061851702
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2718230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.2718230668
MESH:D016889 Endometrial Neoplasms Fenofibrate 7.9416569247
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.183659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.973922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.596401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.327750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.103659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.979664655 16938888
MESH:D005234 Fatty Liver pirinixic acid 2.8219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8620067830
MESH:D005355 Fibrosis Tretinoin 8.8617994277
MESH:D005909 Glioblastoma Tretinoin 3.0417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.2520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.2510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.2514991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Phenobarbital 14.8216109766
MESH:D006529 Hepatomegaly pirinixic acid 14.8218467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.8216120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1418606429 15340226 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.2516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1216580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.1217551590 15992940
MESH:D007674 Kidney Diseases Cadmium 6.7916226777 16962696 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 6.7916962696
MESH:D007938 Leukemia Tretinoin 2.7917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7516932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0817596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1917339181 17361223 16766008 17294898 17368321 19075265 19642359 16823087 17506722 9834237 12679006 17712046 17107899 16935935 17217047 17649720 16140955 17301526 19225113 16891316 15748426 16788101 19029980 16331271 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9221047994
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 5.0215474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0216248980 18397230
MESH:D008107 Liver Diseases Phenobarbital 2.1819363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 22.2318177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.2321137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 22.2317602206
MESH:D008113 Liver Neoplasms Fenofibrate 22.2318978307
MESH:D008113 Liver Neoplasms Phenobarbital 22.2319812893 19482888 19073162 21047994 15975961 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 22.2316377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.2316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.458603461
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 14.4518775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.452563599 1399818 6150874 18308698 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.4512151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3918569708 17053015 6695378 18520028 18816296 20464547 20869020 20064080 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3911884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5617484760
MESH:D009369 Neoplasms Benzo(a)pyrene 8.3411141357
MESH:D009369 Neoplasms pirinixic acid 8.3417405874
MESH:D009369 Neoplasms Tretinoin 8.3416594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.739125849
MESH:D009436 Neural Tube Defects Tretinoin 3.099142499
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010018 Osteomalacia Phenobarbital 4.4517016548
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3616936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3416965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3415976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.4615687053
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.672563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4317292933
MESH:D011471 Prostatic Neoplasms Cadmium 3.4317075824
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.5912752131
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1616116481 16283617
MESH:D012640 Seizures Phenobarbital 2.7311442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.906407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.7519755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.7516192470
MESH:D012878 Skin Neoplasms Tretinoin 13.7516467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3620155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3617261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.331399818
MESH:D013964 Thyroid Neoplasms Tretinoin 7.3316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7316129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
Pathway ID Pathway Name
KEGG:00830 Retinol metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00162 - Z-Mass Pm Vitamin and Mineral Supplement Essential Vitamin;Anti-acne Agents;Vitamins (Vitamin A);Vitamins
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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