AutismKB 2.0

Annotation Detail for RNF43


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Basic Information Top
Gene Symbol:RNF43 ( DKFZp781H02126,DKFZp781H0392,FLJ20315,FLJ77466,FLJ99338,MGC125630,RNF124,URCC )
Gene Full Name: ring finger protein 43
Band: 17q23.2
Quick LinksEntrez ID:54894; OMIM: 612482; Uniprot ID:RNF43_HUMAN; ENSEMBL ID: ENSG00000108375; HGNC ID: 18505
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RNF43 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RNF43 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of RNF43 mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in decreased expression of RNF43 mRNAdecreases expression 16002434
D004958 Estradiol Estradiol results in decreased expression of RNF43 mRNAdecreases expression 20106945
C030110 oxaliplatin oxaliplatin results in increased expression of RNF43 mRNAincreases expression 16510598
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Calcitriol 2.2411237771
MESH:D001943 Breast Neoplasms Estradiol 2.2417289903 18497071 12948864 14630087 16675129 17018787 19861407 17261762
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.763084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7612907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7616924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6911237771
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2718566989
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003110 Colonic Neoplasms oxaliplatin 3.2116004971 16024531 16510598
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9417594712 17255274 17401013 18448328 17695437 18509181
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516485898 16781746 2444490 19416960 17522070 16177239 16393943 11743745 17562736 18713872 12392966 14986274 10663392 18071297 19420014 15968718 12594235 19085960 11421492 11739529 10774834 16109766 19370779 14725611 11529661 17906064 19164858 11461765 19923254 12705907 14550746 12958197 12153990 16081117 15619225 16227642 11834606 12540782 11287661 19739265 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3115138306
MESH:D016889 Endometrial Neoplasms Estradiol 3.1719148513 18566989 11473722
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006930 Hyperalgesia Acetaminophen 8.9016870215
MESH:D006930 Hyperalgesia oxaliplatin 8.9017418472
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007333 Insulin Resistance Estradiol 3.1616627594 16393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.9412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.9410903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 10.9415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.1812371664
MESH:D007680 Kidney Neoplasms Estradiol 8.1815610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 16611625 12587719 19784758 16610002 19460945 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.4415890375 2125692 18177683 9163691
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.928603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8814755239
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7416891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 4.0311399458 16427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2518247401 15754350 16289102 12479363 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 3.2516740699
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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