AutismKB 2.0

Annotation Detail for CDKAL1


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Basic Information Top
Gene Symbol:CDKAL1 ( FLJ20342,FLJ46705,MGC75469 )
Gene Full Name: CDK5 regulatory subunit associated protein 1-like 1
Band: 6p22.3
Quick LinksEntrez ID:54901; OMIM: 611259; Uniprot ID:CDKAL_HUMAN; ENSEMBL ID: ENSG00000145996; HGNC ID: 21050
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Metabolic diseases
Diabetes
H00409Type II diabetes mellitus
No data
Desease Name
ulcerative colitis
type 2 diabetes and other traits
IMMUNE
METABOLIC
type 2 diabetes
Crohn's disease
diabetes, type 2
Posttransplantation diabetes mellitus (PTDM)
Desease Name
Crohn's disease
Type 2 diabetes
Type 2 diabetes and other traits
Desease Name
Diabetes mellitus, noninsulin-dependent, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CDKAL1 mRNAdecreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CDKAL1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CDKAL1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDKAL1 mRNAdecreases expression 20382639
D004041 Dietary Fats Dietary Fats results in decreased expression of CDKAL1 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of CDKAL1 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDKAL1 mRNAaffects binding|increases activity|increases expression 19710929
D012402 Rotenone Rotenone results in decreased expression of CDKAL1 mRNAdecreases expression 19013527
C004648 testosterone enanthate testosterone enanthate affects the expression of CDKAL1 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.963712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.966695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0917474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 2.0920435547
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.113581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1112907637 12619106 21507988
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.107505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1020889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.3519486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0611298694 14531868 18759878 11906362 12868966 2524372 8156756 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism 17460697
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.006679447 18692083 1440618 9022650 11289319 9653073 6482804 8291058 16192314 18289764 7440962 18648102 9328219
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.453581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4520426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4516530937
MESH:D005234 Fatty Liver Dietary Fats 8.3919004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 8.3920131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Dietary Fats 3.7818296743
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly pirinixic acid 3.2519772884 16221962 18467677 19176532
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007249 Inflammation Dietary Fats 2.5220412841
MESH:D007333 Insulin Resistance Dietary Fats 7.6718457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.146582329
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9818296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.799163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7921137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.7920007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.37598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.378603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4720135361 18520028 6695378 17053015 20464547 20064080 18569708 20869020 18816296
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009410 Nerve Degeneration Rotenone 4.0417356569 15790535 18619942
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D009765 Obesity Dietary Fats 4.5821332399 19632207 20132043 11836018 18674790 16723640 20518802 17217161 18457598
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.616482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010300 Parkinson Disease Rotenone 3.0418619942 18191903 16412576 19114014 15451049 19232380 11535288 16140633 11445065
MESH:D020734 Parkinsonian Disorders Rotenone 4.2715795934 15927086 18197244 15574749
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.047505956 6582329 6587162 3712494 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.208074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2017053015
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134871999
    • No data
    Releated disease ID Related disease Name
    PA443886Diabetes Mellitus
    PA443890Diabetes Mellitus, Type 2
    PA443815Crohn Disease
    PA443890Diabetes Mellitus, Type 2
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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