AutismKB 2.0

Annotation Detail for RPP25


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Basic Information Top
Gene Symbol:RPP25 ( FLJ20374 )
Gene Full Name: ribonuclease P/MRP 25kDa subunit
Band: 15q24.2
Quick LinksEntrez ID:54913; OMIM: NA; Uniprot ID:RPP25_HUMAN; ENSEMBL ID: ENSG00000178718; HGNC ID: 30361
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic affects the expression of RPP25 mRNAaffects expression 18414638
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RPP25 mRNAaffects expression 17484886
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D018246 Adrenocortical Adenoma Arsenic 6.2817306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9712569548 16835338 18414634 16251483
MESH:D050197 Atherosclerosis Arsenic 3.5112928151 19371607
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.5416011737 16227642 18705752 15673190 16124888 16192424 3786805 15721981 16097048 16050911 10355542 15700767
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.8317687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.3517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.3518788625
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7917687452 15504454 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.5818640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.7715738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.7818022660 16973168
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.149327722 15998439 19336974 21278145 4309450 2869522 6623471 7179309 10915739 15027814 16177239 6884620 11566570 10092053 7440962 3786805 7120509 3732212 15968718 16227642 19085960 17522070
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.7219224547 15959796 12795759 12631006 61145 17595544 16045604 16239168
MESH:D005355 Fibrosis Carbon Tetrachloride 4.2218705752
MESH:D005534 Foot Diseases Arsenic 6.636392382
MESH:D006505 Hepatitis Carbon Tetrachloride 4.2719900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.4216899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.9617050553
MESH:D006973 Hypertension Arsenic 3.0116076760 11953799 9931084
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.8515338365
MESH:D006987 Hypesthesia Arsenic 6.6316093927
MESH:D007642 Keratosis Arsenic 5.8816930632 12749816
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.8517339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0421278145 17157831 17334410 11903743 16943688 16221502 11408273 16239168 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7617708605 16097048 12666154 15362042 15370692 15673190 12445418 10355542 18054572 15057751 14512876 20821823 12649538 18418968 16136751 12586293 17869086 12609069 15931870 18395095 12389079 12546737 15052691 11481614 18376398 18156304 18317297 12741479 17481882 15996030 17922224 18412020 18277467 18420326 17976157 15893842 17565644 17525996 15818738 15876570 18251166 15650968 18006644 15730626 17823541 18705752 17714472 18429990 18472332 17640975 16638106 17944888 14748882 15338365 17761835 18279442 14716496 14724832 17698563 12632512 15925388 16192424 16116963 17631135 18263696 18205269 16011737 12667390 14620537 18166357 16015684 17900296 18472094 12958196 15959796 16033810 18481824 17721639 17805973 16027843 12445421 14716833 16248980 13678700 17766677 12898905 18395914 18210741 15123356 17557913 12632514 18339082 18187930
MESH:D008107 Liver Diseases Arsenic 4.5511134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.5516964402 16246199 15830285 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.9315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.2014706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 5.2416368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 5.2419294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8912014681 15583823
MESH:D008175 Lung Neoplasms Arsenic 2.2117976673 19168569 17306315
MESH:D017202 Myocardial Ischemia Arsenic 4.3915371236
MESH:D009436 Neural Tube Defects Arsenic 3.7516620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.9817056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.8617306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.8516093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.8815371236 6392382 16905509
MESH:D011471 Prostatic Neoplasms Arsenic 3.5416140617
MESH:D011507 Proteinuria Arsenic 4.6121343184
MESH:D012871 Skin Diseases Arsenic 2.8416353154 17938729 16702368 17548696 16759981 19834688 15952646 17050553 6392382 17453740 18709164
MESH:D012878 Skin Neoplasms Arsenic 3.1917976673 17050553 17029826 15504454 16251483 19538983
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.9617976673 17306315 15987713 18640142 19322015 19429237 11144890
MESH:D014652 Vascular Diseases Arsenic 5.6217056641
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
KEGG:03013 RNA transport
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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