AutismKB 2.0

Annotation Detail for HEATR2


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Basic Information Top
Gene Symbol:HEATR2 ( FLJ20397,FLJ25564,FLJ31671,FLJ39381 )
Gene Full Name: HEAT repeat containing 2
Band: 7p22.3
Quick LinksEntrez ID:54919; OMIM: NA; Uniprot ID:HEAT2_HUMAN; ENSEMBL ID: ENSG00000164818; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HEATR2 mRNAincreases expression 18687144
D004041 Dietary Fats Dietary Fats results in decreased expression of HEATR2 mRNAdecreases expression 18042831
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of HEATR2 mRNAaffects cotreatment|decreases expression 17183730
C041786 palm oil palm oil results in decreased expression of HEATR2 mRNAdecreases expression 18042831
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in decreased expression of HEATR2 mRNAdecreases expression 17982090
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of HEATR2 mRNAaffects cotreatment|decreases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001321 Autistic Disorder Valproic Acid 1.9917157402 18558336 18940202 17507914 18177632 15238991 19232924 18316065 16609825 20603192 18775368 18985861 18396377 19460635 17688650
MESH:D001714 Bipolar Disorder Valproic Acid 3.2120046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.9616474422 17936198 16804969 16867261 18200517 17991707 16782535 18023891 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5317276891
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 8888407 17688650
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2419641884 1733752
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.443922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D005234 Fatty Liver Dietary Fats 9.0018296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Valproic Acid 9.0014986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D005355 Fibrosis Dietary Fats 10.5718296743
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 10.5717994277
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.0416612254
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.6818200517
MESH:D007333 Insulin Resistance Dietary Fats 3.3018457598 11836018
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 5.0217994277
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.4417365036
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2818303189 16966607 16166281
MESH:D008881 Migraine Disorders Valproic Acid 3.4118803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009436 Neural Tube Defects Valproic Acid 3.3216359493 8888407
MESH:D009765 Obesity Dietary Fats 2.3417217161 18674790 21332399 19632207 20518802 11836018 18457598 16723640 20132043
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.5517698068
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.3110923243
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.0612752131 11422049
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1315814490 17365031 17975199 17322281
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9411044598 11738929 3137016 16876388 14763951 15475178 1511512 17978042
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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