AutismKB 2.0

Annotation Detail for CHCHD3


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Basic Information Top
Gene Symbol:CHCHD3 ( FLJ20420 )
Gene Full Name: coiled-coil-helix-coiled-coil-helix domain containing 3
Band: 7q32.3-q33
Quick LinksEntrez ID:54927; OMIM: NA; Uniprot ID:CHCH3_HUMAN; ENSEMBL ID: ENSG00000106554; HGNC ID: 21906
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CHCHD3 mRNAaffects expression 21346803
C013813 4-anisidine 4-anisidine results in decreased expression of CHCHD3 mRNAdecreases expression 12929121
D000082 Acetaminophen Acetaminophen affects the expression of CHCHD3 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CHCHD3 mRNAdecreases expression 20064835
20106945
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CHCHD3 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of CHCHD3 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CHCHD3 mRNAaffects cotreatment|affects expression 17602206
D006918 Hydroxyurea Hydroxyurea results in decreased expression of CHCHD3 mRNAdecreases expression 12929121
D017239 Paclitaxel Paclitaxel results in decreased expression of CHCHD3 mRNAdecreases expression 12929121
C006253 pirinixic acid pirinixic acid results in increased expression of CHCHD3 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 6.946695378
MESH:D000236 Adenoma Diethylnitrosamine 6.946695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.9019052882 19061943 18056438 17620307 17162532 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9016434500
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001859 Bone Neoplasms Paclitaxel 4.7515867366
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9617474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Paclitaxel 1.9616115903 15136595 18223236 11325840 18234424 18323546 16244791 16273361
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.783084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7819052882 16698587 16569478 19919837 18210153 10737359 17978847 18978308 20727157 16830150 19171122 20432363 16935385 20935162 17138121 18971187 20214788 19418558 17761372 16807293 3084413 19335982 19208518 20514400 16288022 19107877 17173139 17162532 16328049 17055752 16502159 20084675 18506893 19394651 18393292 18788625 16779866 10672840 11831363 18494052 21159647 18785209 20524982 16681979 19822196 16540662 20007298 16878318 19701751 3581430 19539802 19519916 18056438 18665156 18691550 19383236 17428255 20512989 20101231
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 6.7816313753
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.9917174075 2727394 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4510774834 11287661 14550746 14725611 15619225 19085960 12153990 16177239 12392966 15968718 12540782 16081117 11529661 16781746 19420014 12705907 10663392 19739265 12958197 11461765 2444490 17906064 16109766 18713872 12594235 18071297 16227642 11739529 17522070 11743745 16393943 10915739 19923254 19416960 14986274 19164858 16485898 11834606 17562736 11421492 19370779
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4519107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7816530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.7816481741
MESH:D005234 Fatty Liver Cyclosporine 14.0819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 14.0820387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 14.0819236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2116221962 19176532 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007249 Inflammation Diethylnitrosamine 2.4618785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.108314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7612371664
MESH:D007951 Leukemia, Myeloid Hydroxyurea 5.1816532439
MESH:D008080 Liposarcoma Paclitaxel 5.0117353645
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9118665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 4.0312969438 16610002 16611625 12587719 19784758 19014921 11587558 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0317034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2021137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 11.2017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2019690152 9163691 16942905 19090486 19427195 10737359 19073162 21047994 19426721 21071580 12112319 20501860 19499222 19996281 18648771 20434301 18754104 19255062 18977376 2862719 19294768 19833225 21278145 19256749 18644402 15885732 19812893 2422723 15175105 20118626 12771043 18978307 20137499 19850985 19254457 20583210 20452335 20492335 20101389 20405173 19638242 19642983 21167192 19551842
MESH:D008113 Liver Neoplasms pirinixic acid 11.2020007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7316842330 3124819 19539802 18164116 19519916 19126423 18308698 18253720 2563599 18775883 9362446 18544905 16267830 18079962 17942915 19009564 17174075 17854601 18282651 18093689 21159647 19004024
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4220064080 18569708 20869020 20135361 17053015 18816296 18520028 6695378 20464547
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.4221163286 20970405 6695378 20512841
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2314749477
MESH:D008545 Melanoma Paclitaxel 2.6116342250 12025231 12040289
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma Paclitaxel 3.8114749477
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.199029167 3581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.1915867366
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0811141357
MESH:D009369 Neoplasms pirinixic acid 5.0817405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5916049721 12819281
MESH:D010014 Osteolysis Paclitaxel 5.2215867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0311161223
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.4612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.462563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3517292933
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.3516729912 17136230 17172428 16356831
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4419755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4920155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4918456281
MESH:D013274 Stomach Neoplasms Paclitaxel 3.4918396642 18506536
MESH:D024801 Tauopathies Paclitaxel 5.0516930453
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.117505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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