AutismKB 2.0

Annotation Detail for PPL


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Basic Information Top
Gene Symbol:PPL ( KIAA0568,MGC134872 )
Gene Full Name: periplakin
Band: 16p13.3
Quick LinksEntrez ID:5493; OMIM: 602871; Uniprot ID:PEPL_HUMAN; ENSEMBL ID: ENSG00000118898; HGNC ID: 9273
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PPL mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPL mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of PPL mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of PPL mRNAaffects expression 17562736
D000968 Antimycin A Antimycin A results in decreased expression of PPL mRNAdecreases expression 19304788
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PPL mRNAdecreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PPL mRNAdecreases expression 15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PPL mRNAincreases expression 15003993
D016572 Cyclosporine Cyclosporine affects the expression of PPL mRNAaffects expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PPL mRNAincreases expression 17557909
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PPL mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of PPL mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PPL mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone Progesterone results in increased expression of PPL mRNAincreases expression 18070364
D012402 Rotenone Rotenone results in decreased expression of PPL mRNAdecreases expression 19304788
D012643 Selenium Selenium results in increased expression of PPL mRNAincreases expression 18583539
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PPL mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PPL mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PPL mRNAincreases expression 17035482
D014810 Vitamin E Vitamin E results in decreased expression of PPL mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.366195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3615322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1820464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.4217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 4.2715380490 15665606 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8320146248 17474063
MESH:D001943 Breast Neoplasms Progesterone 1.8316175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.5616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.563084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.561701930 20007298 20935162 17173139 6705139
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0520419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.586135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5812371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.264080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Cyclosporine 13.3619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.3611677210 16919318 15861022 16105132 17333356 17681005 17110522
MESH:D002779 Cholestasis pirinixic acid 13.3619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1016354765 8697196 15668235 15340226 12621046
MESH:D003092 Colitis Selenium 3.7917936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4820055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4819769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.9418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.0218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.0221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.0215619225 19739265 17562736 12540782 19164858 18071297 2444490 12153990 19923254 10663392 16081117 17906064 16109766 10915739 19085960 11421492 16393943 11834606 18713872 16227642 11743745 19416960 19370779 11461765 12594235 17522070 11739529 14550746 16177239 11287661 12392966 16781746 19420014 14725611 12958197 11529661 10774834 15968718 16485898 14986274 12705907
MESH:D056486 Drug-Induced Liver Injury Selenium 12.0215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.0220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004421 Dystonia Phenobarbital 4.011851702
MESH:C538011 Eales disease Vitamin E 4.739068938
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.0717692515
MESH:D004715 Endometriosis Progesterone 8.9416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.9410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.123659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.903922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.546401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.043659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Cyclosporine 13.0319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.0315345470
MESH:D005234 Fatty Liver pirinixic acid 13.0320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Cyclosporine 8.5312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5320067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.1120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.1110048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 11.1116080930
MESH:D006333 Heart Failure pirinixic acid 6.9620558911
MESH:D006333 Heart Failure Selenium 6.9617162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly Phenobarbital 14.4716109766
MESH:D006529 Hepatomegaly pirinixic acid 14.4718467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.4716120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7016863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.0014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816354765 15340226 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Progesterone 4.9815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812200463 12878042
MESH:D007251 Influenza, Human Selenium 11.0616624496
MESH:D007251 Influenza, Human Vitamin E 11.0616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 10.0115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.0118776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 10.0112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.3816705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.3816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.3812371664
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9021047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4116169303
MESH:D008107 Liver Diseases Acetaminophen 3.9319460945 11587558 19014921 12587719 12969438 16611625 19784758 16610002
MESH:D008107 Liver Diseases Phenobarbital 3.9319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.247678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.2421137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 14.2419812893 15975961 21047994 8742319 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 14.2416377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.2416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.802876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.801399818 18308698 17172636 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8012151625
MESH:D008171 Lung Diseases Vitamin E 3.1816863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3620135361 20869020 17053015 20064080 18520028 18816296 20464547 18569708 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3611884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.3611062179
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.1417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1415318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008654 Mesothelioma Selenium 2.7915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5017484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.417678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8211141357
MESH:D009369 Neoplasms pirinixic acid 4.8217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2918481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 3.8818619942 15790535 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9012819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9016049721
MESH:D010018 Osteomalacia Phenobarbital 4.3817016548
MESH:D010051 Ovarian Neoplasms Progesterone 2.5217393432 16525653
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010300 Parkinson Disease Rotenone 2.9819114014 16140633 11445065 18619942 11535288 19232380 16412576 15451049 18191903
MESH:D020734 Parkinsonian Disorders Rotenone 4.0818197244 15574749 15795934 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010954 Plasmacytoma Selenium 4.9215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.9812371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.982563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1917292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1915084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.5312752131
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012640 Seizures 2,4-dinitrotoluene 9.8218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.8218551238
MESH:D012640 Seizures Phenobarbital 9.8211442880 4039156 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.846407741
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.4019755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.408532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.3015862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.5216517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.051399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.2716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.2716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.0610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0610091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33602
    • No data
    No data
    Releated drug ID Related drug Name
    PA450218levonorgestrel
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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