AutismKB 2.0

Annotation Detail for PARP16


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Basic Information Top
Gene Symbol:PARP16 ( C15orf30,FLJ20509,FLJ25281,pART15 )
Gene Full Name: poly (ADP-ribose) polymerase family, member 16
Band: 15q22.31
Quick LinksEntrez ID:54956; OMIM: NA; Uniprot ID:PAR16_HUMAN; ENSEMBL ID: ENSG00000138617; HGNC ID: 26040
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PARP16 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PARP16 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PARP16 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PARP16 mRNAaffects expression 17562736
D010634 Phenobarbital Phenobarbital results in increased expression of PARP16 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of PARP16 mRNAincreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 10.297525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.296195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.7117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.7116434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.883084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.8820007298 17173139 1701930 6705139 20935162
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.9814694615
MESH:D002386 Cataract Acetaminophen 7.9810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4515095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.6521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.6518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.6521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.6517562736 11739529 19420014 16227642 12392966 17906064 12153990 19085960 11529661 11834606 12594235 18713872 10774834 14725611 14550746 11743745 2444490 12705907 15619225 15968718 12540782 14986274 11421492 19416960 10663392 12958197 19164858 16177239 19923254 16081117 16485898 10915739 16393943 16781746 17522070 11461765 19370779 16109766 11287661 19739265 18071297
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D005234 Fatty Liver pirinixic acid 3.0920131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly Phenobarbital 9.9016109766
MESH:D006529 Hepatomegaly pirinixic acid 9.9019772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2716705839
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1512587719 19784758 16611625 19014921 12969438 19460945 16610002 11587558
MESH:D008107 Liver Diseases Phenobarbital 4.1519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.997678174
MESH:D008113 Liver Neoplasms Phenobarbital 7.998742319 19482888 19073162 19812893 15975961 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 7.9920007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.566135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.566150874 1399818 2563599 17172636 18308698
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.947678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.9912819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.9916049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.9914694615
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5816965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.912563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012640 Seizures 2,4-dinitrotoluene 11.0418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.0418551238
MESH:D012640 Seizures Phenobarbital 11.0416876388 4039156 11442880 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.291399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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