AutismKB 2.0

Annotation Detail for PPM1G


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Basic Information Top
Gene Symbol:PPM1G ( MGC1675,MGC2870,PP2CG,PP2CGAMMA,PPP2CG )
Gene Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1G
Band: 2p23.3
Quick LinksEntrez ID:5496; OMIM: 605119; Uniprot ID:PPM1G_HUMAN; ENSEMBL ID: ENSG00000115241; HGNC ID: 9278
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPM1G mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PPM1G mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PPM1G mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PPM1G mRNAaffects expression 17562736
D002330 Carmustine Carmustine results in decreased expression of PPM1G mRNAdecreases expression 15980968
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PPM1G mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PPM1G mRNAincreases expression 17942748
16174780
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPM1G mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PPM1G mRNAincreases expression 16174780
C030110 oxaliplatin oxaliplatin results in increased expression of PPM1G mRNAincreases expression 17762391
C017947 sodium arsenite sodium arsenite results in decreased expression of PPM1G mRNAdecreases expression 16014739
D013629 Tamoxifen Tamoxifen affects the expression of PPM1G mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPM1G mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PPM1G mRNAincreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PPM1G proteindecreases expression 16548065
D013876 Thiophenes Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of PPM1G mRNA]decreases expression|increases reaction 16140955
D014212 Tretinoin Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of PPM1G mRNA]decreases expression|increases reaction 16140955
D014212 Tretinoin Tretinoin results in decreased expression of PPM1G mRNAdecreases expression 16140955
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.007525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0014514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0816712894 17306315
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3716456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001932 Brain Neoplasms Carmustine 4.4916187019
MESH:D001943 Breast Neoplasms Tamoxifen 1.8321138602 15565566 19244106 19115204 19288272 19011961 17242785 17049068 20005174 19221464 19103187 18855134 18425577 20544844 17261762 16873071 18984771 19487384 18997820 17893378 19200415 19155303 16202921 18815881 20859285 18351453 18821012 15668708 19289846 17440819 19142967 19189210 16273361 20135344 19059307 19410462 19066611 11161223 20065188 19189212 18629630 19084267 20390343 16818667 21152245
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8316873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.6116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.6116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.613084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.6115276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.6116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.611917145
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7816051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.7314694615
MESH:D002386 Cataract Acetaminophen 12.7310977129
MESH:D002386 Cataract Tretinoin 12.7317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.996135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.9920056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9511677210 16919318 17110522 17681005 15861022 16105132 17333356
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9015668235 8697196 15340226 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.909407595
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D003110 Colonic Neoplasms oxaliplatin 3.1916004971 16510598 16024531
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9418509181 18448328 17695437 17255274 17594712 17401013
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.5215095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.5214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4810048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.489142499 10589399 9211117 17551590 14991402 16925845 9664655 8800419 9224671 9125849
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.3421346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3417562736 16177239 19164858 18713872 19420014 15968718 16393943 19085960 12594235 14986274 15619225 17906064 12153990 12705907 12392966 11739529 19923254 18071297 17522070 16109766 2444490 19416960 12540782 16081117 19370779 11743745 16485898 11461765 10663392 11834606 11421492 11287661 14550746 19739265 10774834 16781746 11529661 16227642 14725611 12958197 10915739
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5315322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6716202921 19155303 20544844 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.119664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0615345470
MESH:D005234 Fatty Liver Tamoxifen 8.0619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0920067830
MESH:D005355 Fibrosis Tretinoin 9.0917994277
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8316452187
MESH:D005909 Glioblastoma Carmustine 7.6916187019
MESH:D005909 Glioblastoma Tretinoin 7.6917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.729664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.2512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 13.6816870215
MESH:D006930 Hyperalgesia oxaliplatin 13.6817418472
MESH:D006930 Hyperalgesia Tretinoin 13.6816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8817937319
MESH:D007248 Infertility, Male sodium arsenite 6.8812646999 15346721
MESH:D007249 Inflammation Tamoxifen 5.0719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.3017551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 6.1620008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9516705839
MESH:D007680 Kidney Neoplasms Tamoxifen 12.9518625569
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8116932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0916294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Thiophenes 8.4616140955 16140954
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.4619075265 15748426 17301526 17217047 19225113 16140955 16891316 17339181 17294898 16331271 16935935 16766008 17361223 17107899 16823087 17712046 9834237 17368321 19029980 17506722 16788101 12679006 19035177 17649720 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 16611625 19014921 19784758 12587719 11587558 16610002 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.017678174
MESH:D008113 Liver Neoplasms sodium arsenite 11.0115276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 11.0116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.956135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008171 Lung Diseases sodium arsenite 3.2419095001
MESH:D008175 Lung Neoplasms sodium arsenite 3.4517077188 19931552 17306315 15276417 16712894
MESH:D008175 Lung Neoplasms Tamoxifen 3.4518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4519555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6911731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Carmustine 7.4912393984
MESH:D008545 Melanoma sodium arsenite 7.4919082730 16487513
MESH:D008545 Melanoma Tamoxifen 7.4912393984 19393235
MESH:D008545 Melanoma Tretinoin 7.4916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms sodium arsenite 5.2811559025
MESH:D009369 Neoplasms Tretinoin 5.2816594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8020056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9414600291
MESH:D009421 Nervous System Malformations Tretinoin 9.949125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.5412854658
MESH:D009436 Neural Tube Defects Tretinoin 7.549142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.7712819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.7716049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.7714694615
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9916936753
MESH:D010146 Pain Acetaminophen 6.8916870215
MESH:D010146 Pain Tretinoin 6.8916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11399792 11222880 11118676
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2316039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2315067354
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012878 Skin Neoplasms sodium arsenite 9.7119524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7116192470
MESH:D012878 Skin Neoplasms Tretinoin 9.7116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8812854658
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.2516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.2516049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.2516452187 16712894 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.2517572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.7611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.7616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D014652 Vascular Diseases sodium arsenite 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33606
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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