AutismKB 2.0

Annotation Detail for SSH3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SSH3 ( FLJ10928,FLJ20515,FLJ42240,SSH3L )
Gene Full Name: slingshot homolog 3 (Drosophila)
Band: 11q13.2
Quick LinksEntrez ID:54961; OMIM: 606780; Uniprot ID:SSH3_HUMAN; ENSEMBL ID: ENSG00000172830; HGNC ID: 30581
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SSH3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SSH3 mRNAaffects expression 17562736
D004317 Doxorubicin Doxorubicin results in increased expression of SSH3 mRNAincreases expression 16404146
D007657 Ketone Bodies Ketone Bodies results in increased expression of SSH3 mRNAincreases expression 16807920
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 2.6417418594
MESH:D000419 Albuminuria Doxorubicin 5.0521441931
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.4214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.2017150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.5817983394 16826403 16115903 17426702 18628466 16322301 11325840 15136595 19526202 15567936 16096432 18382427 16264153 16595493 18234424 15993339 18695136 15692762 17369602 16935488 15668708 15994142 15939500 15634643
MESH:D002276 Carcinoid Tumor Doxorubicin 5.5316051944
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.843084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.8416234567 18059187 16023760 17876044
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.311485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.726189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7716109756 16242529 17924179 16364871 16269455 15476868 17928571 17351982 17007740 17519947 15792986 17131338 16612575 17308081 15811867 18627295 17974986 17329180 16731534 16455267 16278810 16651473 17382496 16952015 15505089
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0516243910 17334414
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1518259882 18802399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5818551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7916227642 16485898 10774834 19420014 11834606 11743745 16081117 12540782 14986274 11739529 12392966 19739265 11421492 18713872 12958197 19164858 15968718 11461765 16781746 17906064 15619225 11287661 19085960 19416960 12705907 14550746 16109766 10915739 17522070 18071297 16177239 19370779 14725611 19923254 12594235 2444490 11529661 17562736 10663392 16393943 12153990
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.7917416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004362 Drug Toxicity Doxorubicin 3.9618602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6917359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.8818037988
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.2219069698
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005909 Glioblastoma Doxorubicin 3.5917150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7815692506
MESH:D006331 Heart Diseases Doxorubicin 3.7516879835 16330681 18674790 17875725 18006777 17888722 16244371 12587719 16144979 16707910 14766674 16244372 16495754
MESH:D006333 Heart Failure Doxorubicin 3.5617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.3315692506
MESH:D006689 Hodgkin Disease Doxorubicin 3.7715147373 18501091 17606976
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007674 Kidney Diseases Acetaminophen 6.7415629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 6.7415369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.5816707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.3216705839
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.8816085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1616439617 16595196
MESH:D008107 Liver Diseases Acetaminophen 1.7016610002 19460945 19014921 12969438 19784758 16611625 11587558 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.2417085340 16842330
MESH:D008175 Lung Neoplasms Doxorubicin 2.156189445 17418594
MESH:D008223 Lymphoma Doxorubicin 3.7316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.1317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 5.1315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2615458769
MESH:D008545 Melanoma Doxorubicin 2.3316827129
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008654 Mesothelioma Doxorubicin 3.1817638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.9315792986
MESH:D052016 Mucositis Doxorubicin 5.4217415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0815857846 19429709
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4918551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0818259882
MESH:D009401 Nephrosis Doxorubicin 5.3316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.3716889571 15640375
MESH:D009447 Neuroblastoma Doxorubicin 3.4315555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.8212819281 16049721
MESH:D012516 Osteosarcoma Doxorubicin 4.4415930896
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D003557 Phyllodes Tumor Doxorubicin 5.8817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.8817638057
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4915897917 16868541 16729912 18437689 16888761 15749863
MESH:D051437 Renal Insufficiency Doxorubicin 4.7817922066
MESH:D012509 Sarcoma Doxorubicin 4.3815675481 17710206 15625365 17203757 16767912 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.7516326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.4217846226
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7918551238
MESH:D012878 Skin Neoplasms Doxorubicin 3.1115692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 5.1317203757 16767912 15625365
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6717909728 16010429
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.6116049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.6117653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.9510091137
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.7817678736 16364871 17334414 17638931
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved