AutismKB 2.0

Annotation Detail for TIPIN


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Basic Information Top
Gene Symbol:TIPIN ( FLJ20516 )
Gene Full Name: TIMELESS interacting protein
Band: 15q22.31
Quick LinksEntrez ID:54962; OMIM: 610716; Uniprot ID:TIPIN_HUMAN; ENSEMBL ID: ENSG00000075131; HGNC ID: 30750
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of TIPIN mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of TIPIN mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TIPIN mRNAdecreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TIPIN mRNAdecreases expression 20382639
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TIPIN mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TIPIN mRNA]decreases reaction|increases expression 17854601
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of TIPIN mRNAincreases expression 20713471
C006253 pirinixic acid pirinixic acid results in increased expression of TIPIN mRNAincreases expression 18301758
C004648 testosterone enanthate testosterone enanthate affects the expression of TIPIN mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 11.986695378
MESH:D000236 Adenoma Diethylnitrosamine 11.986695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 11.986695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2416434500 18056438 19052882 17162532 17620307 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2416434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5811922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9617474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.9617474063
MESH:D002277 Carcinoma Methylcholanthrene 4.1610545420
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7019171122 19418558 19701751 19383236 18210153 18971187 20524982 20514400 16288022 18494052 20084675 19107877 11831363 17162532 21159647 20101231 17055752 17428255 19208518 16540662 16779866 16878318 17978847 16698587 18393292 18691550 10672840 18056438 19394651 18665156 3581430 10737359 20214788 16681979 17138121 20512989 17761372 20432363 16935385 16830150 19919837 18978308 16569478 18788625 20007298 20727157 19335982 18506893 18785209 19519916 3084413 19539802 19052882 16807293 17173139 16502159 20935162 19822196 16328049
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.416135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.4120889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 17.4117174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 17.4116192471
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5418713872 19739265 10663392 16781746 10774834 11739529 19370779 18071297 17562736 12705907 16109766 11287661 19085960 14725611 16485898 11743745 2444490 10915739 19164858 14550746 12153990 19416960 14986274 17906064 12594235 11461765 11834606 12540782 16081117 16227642 19420014 15968718 12958197 11529661 19923254 16393943 16177239 12392966 17522070 15619225 11421492
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5419107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D005234 Fatty Liver Diethylnitrosamine 8.5020387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.5019236843 20131406
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.2814633661 10962813
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 18467677 19772884 19176532
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1217440010
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1816705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9420032147 18407596 18522880 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.0819784758 12969438 19460945 16610002 19014921 11587558 16611625 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.347678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.3420195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.3410737359 21071580 19638242 2862719 20101389 20583210 21278145 19294768 18648771 18978307 20137499 2422723 20492335 21167192 21047994 19850985 20452335 19642983 12112319 19090486 16942905 20434301 19812893 19833225 20405173 19996281 19426721 20118626 19254457 19551842 18644402 19255062 12771043 15885732 19690152 20501860 18977376 9163691 19256749 19427195 15175105 19073162 18754104 19499222
MESH:D008113 Liver Neoplasms pirinixic acid 11.3415890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.776135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.7719004024 17942915 21159647 18079962 19539802 19126423 16267830 18093689 9362446 18544905 17854601 3124819 19519916 18253720 19009564 18775883 17174075 18164116 18308698 16842330 18282651 2563599
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.771399818 598648
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6318520028 20464547 17053015 18816296 20869020 18569708 20064080 6695378 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.6321163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.6315390079 16271038 1399818 20970405 9230183 17909032 11893704 21163286 7750092 6695378 16337739 20512841 10545420
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4610029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3820155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3818456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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