AutismKB 2.0

Annotation Detail for TMEM70


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Basic Information Top
Gene Symbol:TMEM70 ( FLJ20533 )
Gene Full Name: transmembrane protein 70
Band: 8q21.11
Quick LinksEntrez ID:54968; OMIM: 612418; Uniprot ID:TMM70_HUMAN; ENSEMBL ID: ENSG00000175606; HGNC ID: 26050
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Desease Name
Encephalocardiomyopathy, neonatal, mitochondrial, due to ATP synthase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TMEM70 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TMEM70 mRNAaffects expression 17484886
C006253 pirinixic acid pirinixic acid results in increased expression of TMEM70 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D000799 Angioedema Acetaminophen 4.7110982225
OMIM:604273 ATPase DEFICIENCY, NUCLEAR-ENCODED ENCEPHALOCARDIOMYOPATHY, MITOCHONDRIAL, NEONATAL, DUE TO ATP SYNTHASE marker/mechanism
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.4315721981 16124888 3786805 16011737 16227642 15700767 10355542 18705752 16192424 16050911 16097048 15673190
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.003084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0018788625
MESH:D009202 Cardiomyopathies marker/mechanism 18953340
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0812705907 11287661 15619225 11743745 16109766 12540782 10774834 19420014 14986274 11529661 17522070 11739529 11421492 11461765 11834606 19164858 16227642 16485898 16177239 18713872 16081117 17906064 19085960 10663392 15968718 19739265 12958197 14550746 12392966 12594235 14725611 19370779 18071297 19416960 17562736 16393943 2444490 16781746 19923254 10915739 12153990
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0810092053 15998439 2869522 16227642 10915739 16177239 21278145 17522070 11566570 15968718 6623471 7179309 15027814 19336974 3732212 3786805 7120509 19085960 4309450 6884620 7440962 9327722
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.3212795759 16239168 19224547 15959796 61145 17595544 12631006 16045604
MESH:D005234 Fatty Liver pirinixic acid 9.3220131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 4.1018705752
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.6419772884 18467677 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.2716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.7415338365
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0217174718 16943688 17334410 17157831 11408273 21278145 11903743 16221502 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4218054572 14716496 18420326 16248980 16116963 12649538 11481614 17557913 12445418 12445421 16011737 18187930 15650968 18156304 15893842 12958196 15370692 15673190 12389079 18472094 15052691 12546737 18705752 17708605 16033810 16015684 18166357 14748882 14724832 15876570 14716833 15730626 17565644 18277467 15057751 15123356 17698563 15996030 14512876 12632514 16638106 12898905 14620537 15818738 12609069 15362042 17944888 12632512 18263696 17631135 18481824 13678700 18006644 18251166 18317297 12666154 15931870 17481882 20821823 12741479 17922224 17823541 18395095 18339082 17900296 18205269 16097048 17525996 15925388 18472332 17976157 17869086 15959796 17721639 17766677 18279442 12586293 18412020 15338365 17805973 17761835 12667390 18418968 18395914 17714472 16192424 10355542 16027843 17640975 18429990 16136751 18376398 18210741
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4215474484
MESH:D008107 Liver Diseases Acetaminophen 4.1916610002 12969438 16611625 19460945 19014921 19784758 11587558 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1916964402 15720792 15830285 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.8215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.9416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.9416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8819294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.8815890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8612014681 15583823
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D017237 Mitochondrial Encephalomyopathies marker/mechanism 18953340
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D014581 Urticaria Acetaminophen 3.5010982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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