AutismKB 2.0

Annotation Detail for HCFC1R1


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Basic Information Top
Gene Symbol:HCFC1R1 ( FLJ20568,HPIP,MGC70711,MGC99622 )
Gene Full Name: host cell factor C1 regulator 1 (XPO1 dependent)
Band: 16p13.3
Quick LinksEntrez ID:54985; OMIM: NA; Uniprot ID:HPIP_HUMAN; ENSEMBL ID: ENSG00000103145; HGNC ID: 21198
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HCFC1R1 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HCFC1R1 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of HCFC1R1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of HCFC1R1 mRNAdecreases expression 20106945
D019833 Genistein Genistein results in increased expression of HCFC1R1 mRNAincreases expression 18847459
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of HCFC1R1 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid pirinixic acid results in increased expression of HCFC1R1 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HCFC1R1 mRNAdecreases expression 19465110
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of HCFC1R1 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in increased expression of HCFC1R1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2815322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Genistein 2.5211473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9916609825 15238991 18940202 18558336 18396377 17507914 17157402 18985861 19460635 18775368 19232924 18316065 18177632 20603192 17688650
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.1717594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.438888407
MESH:D001943 Breast Neoplasms Genistein 2.0616873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0416192424 3786805 16050911 15721981 16097048 15700767 18705752 16227642 16011737 10355542 16124888 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.773581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7718788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7716924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.4416332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.037505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0312371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.2719486331 9022650
MESH:D002779 Cholestasis Cyclosporine 14.2719486331
MESH:D002779 Cholestasis pirinixic acid 14.2719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 15340226 15668235 8697196 12621046
MESH:D003110 Colonic Neoplasms Genistein 2.3117182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5217688650 16575769 8888407
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0611298694 12868966 8970840 8156756 14531868 18759878 11906362 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4717107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.429653073 9328219 18692083 1440618 18289764 9022650 7440962 8291058 11289319 6679447 16192314 6482804 18648102
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.4215998439 17522070 6623471 10915739 7120509 4309450 7179309 21278145 10092053 9327722 6884620 19085960 3786805 16227642 11566570 15968718 19336974 7440962 15027814 16177239 2869522 3732212
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.421733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004714 Endometrial Hyperplasia Genistein 4.8716402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4911473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.777562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.5561145 19224547 16239168 15959796 16045604 12631006 17595544 12795759
MESH:D005234 Fatty Liver Cyclosporine 20.5519224547
MESH:D005234 Fatty Liver pirinixic acid 20.5519236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 20.5519224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Carbon Tetrachloride 16.2918705752
MESH:D005355 Fibrosis Cyclosporine 16.2912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.2920067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Genistein 3.3816598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.036705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.0319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 9.1419176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1412621046 15340226 16120746
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3618606429 15340226 16959395 8697196 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8816612254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.448314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.856582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D007938 Leukemia Genistein 3.1118980019 17468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9117174718 11408273 17334410 16943688 16221502 17157831 16239168 11903743 21278145
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1016192424 18412020 16011737 15338365 17900296 16638106 10355542 17805973 15057751 17708605 12667390 17922224 15123356 18210741 17944888 17761835 18263696 17714472 18420326 16248980 18166357 18395914 11481614 18376398 17565644 18277467 18205269 15931870 15650968 18251166 20821823 14716496 16097048 12546737 12741479 16015684 14716833 15730626 12586293 18472332 18279442 15673190 15362042 14748882 18187930 17823541 18395095 12666154 18705752 17557913 17721639 12898905 18339082 12632514 15818738 18472094 17525996 17481882 12632512 16136751 13678700 17869086 18317297 12649538 15893842 15925388 16116963 15370692 17766677 14620537 12958196 14724832 17976157 12389079 18156304 12445418 15959796 18054572 12609069 14512876 12445421 17698563 17640975 18006644 15996030 16027843 18429990 18418968 15052691 18481824 15876570 17631135 16033810
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.1017823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1012878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216246199 15720792 16964402 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7319294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.7315890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.49598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4912151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0614578162 12929590
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D009203 Myocardial Infarction Genistein 5.9317141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.9319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.9217141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.9216411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Genistein 10.4116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.686679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.688888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010024 Osteoporosis Genistein 3.3719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3116169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6519005980
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4311118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.4320603192
MESH:D011471 Prostatic Neoplasms Genistein 3.4315256057 15378649 16925846
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.871511512 11738929 14763951 16876388 11044598 15475178 3137016 17978042
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.047505956 6582329 1399818 6587162 3712494
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.348074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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