AutismKB 2.0

Annotation Detail for PPP1CA


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Basic Information Top
Gene Symbol:PPP1CA ( MGC15877,MGC1674,PP-1A,PP1alpha,PPP1A )
Gene Full Name: protein phosphatase 1, catalytic subunit, alpha isozyme
Band: 11q13
Quick LinksEntrez ID:5499; OMIM: 176875; Uniprot ID:PP1A_HUMAN; ENSEMBL ID: ENSG00000172531; HGNC ID: 9281
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04910Insulin signaling pathway
hsa04720Long-term potentiation
hsa04114Oocyte meiosis
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
Pathway IDPathway Name
Opioid Signalling
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200123BMP receptor signaling
200126ALK1 signaling events
200195TGF-beta receptor signaling
No data
Pathway IDPathway Name
500841DARPP-32 events
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of PPP1CA mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of PPP1CA mRNAaffects expression 17562736
C010845 aluminum chloride aluminum chloride results in decreased expression of PPP1CA proteindecreases expression 15113600
D000584 Amiloride Amiloride results in decreased phosphorylation of PPP1CA proteindecreases phosphorylation 16059913
D000584 Amiloride Okadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of PPP1CA protein]decreases phosphorylation|decreases reaction 16059913
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PPP1CA mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of PPP1CA mRNAdecreases expression 16623957
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PPP1CA mRNAdecreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PPP1CA mRNAdecreases expression 12419474
D002118 Calcium Calcium affects the expression of PPP1CA mRNAaffects expression 15913539
C045651 epigallocatechin gallate [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of PPP1CA proteinaffects cotreatment|increases expression 18348186
D005419 Flavonoids Flavonoids results in decreased expression of PPP1CA mRNAdecreases expression 18035473
D005472 Fluorouracil PPP1CA protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D007052 Ibuprofen [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of PPP1CA proteinaffects cotreatment|increases expression 18348186
D019810 Sodium Azide Sodium Azide results in decreased expression of PPP1CA proteindecreases expression 15113600
D019319 Okadaic Acid Okadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of PPP1CA protein]decreases phosphorylation|decreases reaction 16059913
D019319 Okadaic Acid Okadaic Acid results in decreased activity of PPP1CA proteindecreases activity 15767308
D019319 Okadaic Acid Okadaic Acid results in decreased activity of PPP1CA proteindecreases activity 16059913
D012643 Selenium Selenium results in increased expression of PPP1CA mRNAincreases expression 19244175
C016104 sodium bichromate sodium bichromate results in decreased expression of PPP1CA mRNAdecreases expression 12760830
C025643 vinclozolin vinclozolin affects the expression of PPP1CA mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of PPP1CA mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D058186 Acute Kidney Injury Ibuprofen 4.396375363
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1420127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 7.1417638652
MESH:D000230 Adenocarcinoma Ibuprofen 7.1410697514
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D000544 Alzheimer Disease Ibuprofen 3.1518351690
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0610965797
MESH:D000707 Anaphylaxis Ibuprofen 5.189532969
MESH:D000740 Anemia Fluorouracil 3.6516511603 17963324 15504547
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.5819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001249 Asthma epigallocatechin gallate 3.3716516891
MESH:D001321 Autistic Disorder Acetaminophen 2.2318445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2318582451
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 5.0019761891
MESH:D002545 Brain Ischemia Ibuprofen 4.8215837124
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1920146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.1919217205 18357371 15136595 16110121 16557594 18608205 16595493
MESH:D002100 Cachexia Ibuprofen 5.4115141370
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8716050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6116051944
MESH:D002277 Carcinoma Fluorouracil 3.5117121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.9117971768 16332177 17088986 16799960 18930000 17045692
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5820419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.5818986760 16280240 16757204 17066447
MESH:D002295 Carcinoma, Transitional Cell Amiloride 5.0214644129
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D003092 Colitis Amiloride 9.8012065299
MESH:D003092 Colitis Selenium 9.8017936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2217287894 16510598 18772588 16340194 17172411 17725105 17018589 15001691 17169374 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018802399 16303861 18448328 18509181 16391804 16331619 18288408 15148649 17594712 17454858 15289873 16524972 17016601 17094418 18949393 16282729 14970324 17695437 20501625 17401013 17255274 18383874
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003456 Cryptorchidism vinclozolin 4.2814966744
MESH:D007644 Darier Disease Fluorouracil 4.7316733453
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 3.2616988119
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7316227642 14986274 15619225 16781746 17522070 19416960 2444490 19085960 19923254 11739529 11421492 18071297 16485898 11287661 10663392 19739265 17562736 14725611 12958197 11461765 11834606 16081117 19370779 10915739 12392966 11743745 19164858 16109766 12153990 14550746 12594235 17906064 16393943 12540782 18713872 15968718 19420014 16177239 10774834 12705907 11529661
MESH:D056486 Drug-Induced Liver Injury Selenium 3.7315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.5516133044 18446180 18450898
MESH:C538011 Eales disease Vitamin E 4.659068938
MESH:D004487 Edema Arachidonic Acid 3.9816716910 9599246 11698051 7990266 15177302 9831321
MESH:D004715 Endometriosis Ibuprofen 4.5515652904
MESH:D019446 Endotoxemia Ibuprofen 4.9011545620
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4316337965 16481741 17638652 15173087 16785472
MESH:D005334 Fever Arachidonic Acid 9.5611852909
MESH:D005334 Fever Ibuprofen 9.5616997862
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2416417039
MESH:D005909 Glioblastoma Okadaic Acid 4.5817312396
MESH:D005910 Glioma Fluorouracil 2.8416145905
MESH:D006130 Growth Disorders Amiloride 4.7119703807
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3418337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5720471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.5716080930
MESH:D006333 Heart Failure Selenium 3.0317162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6816490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.9214716179
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006973 Hypertension Amiloride 3.8518524855 15174897 19344079
MESH:D006984 Hypertrophy Ibuprofen 4.9116672835
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 5.7919822448
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.7816133044
MESH:D007248 Infertility, Male vinclozolin 3.0016467254
MESH:D007249 Inflammation Amiloride 11.8817237260
MESH:D007249 Inflammation Arachidonic Acid 11.889831321 17371808 15177302
MESH:D007249 Inflammation Flavonoids 11.8817296493
MESH:D007249 Inflammation Ibuprofen 11.883291741
MESH:D007251 Influenza, Human Selenium 10.7716624496
MESH:D007251 Influenza, Human Vitamin E 10.7716624496
MESH:D007674 Kidney Diseases Acetaminophen 5.8412587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 5.8412488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8216518626
MESH:D007680 Kidney Neoplasms Fluorouracil 3.2516985049
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.9916316344
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6716417039
MESH:D056929 Liddle Syndrome Amiloride 5.9119344079
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 2.9117481882
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.9116169303
MESH:D008107 Liver Diseases Acetaminophen 1.6119460945 12969438 19784758 11587558 19014921 16611625 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1817185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5320195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 4.5317045692 15113037 18383874 16603448
MESH:D008171 Lung Diseases Vitamin E 3.1316863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4220869020 18569708 6695378 18816296 17053015 20464547 18520028 20135361 20064080
MESH:D008175 Lung Neoplasms Fluorouracil 3.4215246190
MESH:D008175 Lung Neoplasms Vitamin E 3.4211062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7315086387
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 6.3010697514
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3015318939
MESH:D008545 Melanoma epigallocatechin gallate 2.9817992120 11746506
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008654 Mesothelioma Selenium 2.7715107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.3616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.3616757204 18986760
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.4317962980
MESH:D009361 Neoplasm Invasiveness Amiloride 5.2414644129
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9611141357
MESH:D009369 Neoplasms Fluorouracil 4.9618239605 18600527 16928823
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.936375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.3310961664
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3916436463
MESH:D010003 Osteoarthritis Ibuprofen 4.097009135
MESH:D010024 Osteoporosis Calcium 3.7417882678
MESH:D010146 Pain Acetaminophen 6.7816870215
MESH:D010146 Pain Ibuprofen 6.783291741
MESH:D010149 Pain, Postoperative Ibuprofen 5.0916678543
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6416500647 19003803 16929163 15113037
MESH:D010190 Pancreatic Neoplasms Ibuprofen 5.6412384795
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.4511550810
MESH:D010954 Plasmacytoma Selenium 4.8315087411
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.8418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.8718220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1317292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1319082440 18626508
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.1317409433
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1315084515
MESH:D011472 Prostatitis vinclozolin 4.8718629315
MESH:D011507 Proteinuria Ibuprofen 4.566375363
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9518722050 15538739 16160472 18286688
MESH:D012871 Skin Diseases Vitamin E 2.4218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.5110029692 19755658
MESH:D012878 Skin Neoplasms Okadaic Acid 9.5112628509
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.518532709
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4016951190 16424979 15786421 17522103 17172411 18396642 19084572 17498489 18567086 19015929
MESH:D020521 Stroke Vitamin E 3.4716517955
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9316280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1517053015
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8216803524
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.1319057314
Pathway ID Pathway Name
KEGG:04510 Focal adhesion
KEGG:04910 Insulin signaling pathway
KEGG:04720 Long-term potentiation
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04810 Regulation of actin cytoskeleton
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33609
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    PA449396dopamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02506 - 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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