AutismKB 2.0

Annotation Detail for TESC


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Basic Information Top
Gene Symbol:TESC ( CHP3,FLJ20607,TSC )
Gene Full Name: tescalcin
Band: 12q24.22
Quick LinksEntrez ID:54997; OMIM: 611585; Uniprot ID:TESC_HUMAN; ENSEMBL ID: ENSG00000088992; HGNC ID: 26065
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of TESC mRNAdecreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TESC mRNAdecreases expression 20064835
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TESC mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.363712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.366695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.8911289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.783581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.847296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1420419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.057505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.9419486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.9419176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.448970840 8156756 18759878 12868966 11298694 2524372 14531868 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.022952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0511289319 1440618 18692083 9328219 8291058 6679447 18648102 7440962 18289764 16192314 9022650 6482804 9653073
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.653581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6516530937
MESH:D005234 Fatty Liver pirinixic acid 3.2520131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.896705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.577505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8520471113
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.106705139
MESH:D006529 Hepatomegaly pirinixic acid 3.6416221962 19772884 18467677 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5915034207
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.898074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.356582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8121137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.8115890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.78598648 1399818 3712494 6587162
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720464547 18520028 18569708 20869020 18816296 17053015 6695378 20064080 20135361
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.613581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4411141357
MESH:D009369 Neoplasms pirinixic acid 5.4417405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.186679447
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.876482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.893988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.137296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.346228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.703692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5419755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.221399818 6587162 7505956 6582329 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.438074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4317053015
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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