AutismKB 2.0

Annotation Detail for PAK1IP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PAK1IP1 ( FLJ20624,MAK11,PIP1,RP11-421M1.5,WDR84,bA421M1.5,hPIP1 )
Gene Full Name: PAK1 interacting protein 1
Band: 6p24.2
Quick LinksEntrez ID:55003; OMIM: 607811; Uniprot ID:PK1IP_HUMAN; ENSEMBL ID: ENSG00000111845; HGNC ID: 20882
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016572 Cyclosporine Cyclosporine results in increased expression of PAK1IP1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PAK1IP1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PAK1IP1 mRNAincreases expression 17942748
D026023 Permethrin Permethrin results in increased expression of PAK1IP1 mRNAincreases expression 19017407
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PAK1IP1 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone Progesterone results in decreased expression of PAK1IP1 mRNAdecreases expression 18037150
D013629 Tamoxifen Tamoxifen affects the expression of PAK1IP1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PAK1IP1 mRNAincreases expression 16611356
C025643 vinclozolin vinclozolin affects the expression of PAK1IP1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615845082 15380490 15665606
MESH:D001943 Breast Neoplasms Progesterone 1.8515562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 1.8519084267 17242785 17049068 18425577 15565566 20859285 20135344 16818667 19221464 19288272 19011961 19410462 19115204 19103187 17893378 16202921 18815881 19244106 18855134 18997820 16873071 19200415 19189212 21152245 19155303 19142967 17440819 18629630 20544844 18984771 19189210 19289846 19487384 21138602 18351453 16273361 15668708 20390343 11161223 20065188 17261762 19059307 20005174 18821012 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8416924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 14.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.3817681005 17110522 16105132 15861022 16919318 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 14.3819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 12621046 8697196 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Permethrin 3.0019861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.0015322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact Permethrin 5.2514617103
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.0312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 17.0317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.0319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1917893378 19155303 16202921 20544844
MESH:D004715 Endometriosis Progesterone 9.7016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.7010568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 20.8519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8515345470
MESH:D005234 Fatty Liver pirinixic acid 20.8519236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 20.8514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Cyclosporine 9.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 18606429 8697196 16354765 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1717937319
MESH:D007248 Infertility, Male vinclozolin 7.1716467254
MESH:D007249 Inflammation Progesterone 8.9715869954
MESH:D007249 Inflammation Tamoxifen 8.9719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.9712878042 12200463
MESH:D007299 Insect Bites and Stings Permethrin 6.2012971516 15189238 12749493
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.9818625569
MESH:D007938 Leukemia Permethrin 4.2312937054
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008113 Liver Neoplasms pirinixic acid 7.7915890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.3018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3019555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.5711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5714580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms Progesterone 2.5816525653 17393432
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6411222880 11399792 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.6418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Progesterone 12.0216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 12.0219457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4316712894 8653321 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved