AutismKB 2.0

Annotation Detail for HERC6


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Basic Information Top
Gene Symbol:HERC6 ( FLJ20637 )
Gene Full Name: hect domain and RLD 6
Band: 4q22.1
Quick LinksEntrez ID:55008; OMIM: 609249; Uniprot ID:HERC6_HUMAN; ENSEMBL ID: ENSG00000138642; HGNC ID: 26072
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HERC6 mRNAaffects expression 21346803
D016572 Cyclosporine Cyclosporine results in decreased expression of HERC6 mRNAdecreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HERC6 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of HERC6 mRNAincreases expression 19619570
D018038 Sodium Selenite Sodium Selenite results in decreased expression of HERC6 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HERC6 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HERC6 mRNAdecreases expression 19619570
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of HERC6 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 15322242 14514962
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.249612607
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Estradiol 1.9117289903 17261762 12948864 16675129 19861407 14630087 17018787 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0816705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0816924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 15340226 15668235 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 9.0111462148
MESH:D004362 Drug Toxicity Zidovudine 9.0115040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.1711473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Cyclosporine 9.0819224547
MESH:D005234 Fatty Liver Zidovudine 9.0818299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Cyclosporine 9.9112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.9120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006402 Hematologic Diseases Zidovudine 5.0612579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D015658 HIV Infections Zidovudine 3.6320032539 11141242 11698656 17358032 11363243
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16354765 15340226 18606429 16959395
MESH:D006973 Hypertension Cyclosporine 5.2810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2818670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 8.0816627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 8.0814714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.4918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.4915618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 20.1016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 20.1012371664
MESH:D007680 Kidney Neoplasms Estradiol 20.1015610895
MESH:D007680 Kidney Neoplasms Zidovudine 20.1012579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.7420370541
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5919555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 2.5918800350
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7416891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.3617358032
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.7711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.7714600291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7312819281 16049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1916740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.1918760546
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014625 Vaginal Neoplasms Zidovudine 5.1812579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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