AutismKB 2.0

Annotation Detail for TTC38


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Basic Information Top
Gene Symbol:TTC38 ( FLJ20699 )
Gene Full Name: tetratricopeptide repeat domain 38
Band: 22q13.31
Quick LinksEntrez ID:55020; OMIM: NA; Uniprot ID:TTC38_HUMAN; ENSEMBL ID: ENSG00000075234; HGNC ID: 26082
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TTC38 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TTC38 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of TTC38 mRNAincreases expression 15761015
D016572 Cyclosporine Cyclosporine results in decreased expression of TTC38 mRNAdecreases expression 20106945
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TTC38 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of TTC38 mRNAincreases expression 19270015
19482888
D018038 Sodium Selenite Sodium Selenite results in increased expression of TTC38 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.906195326
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.4317620307
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0016206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.903084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.9021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.9015073043 16217749 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.901701930 20007298 17173139 6705139 20935162
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0810774834 12540782 12958197 12153990 11421492 17906064 15619225 19420014 17522070 18713872 16227642 17562736 16177239 11529661 15968718 12705907 16081117 11739529 16109766 19370779 14986274 16393943 12392966 11743745 11834606 16781746 19085960 11287661 14725611 10915739 18071297 19164858 16485898 10663392 14550746 11461765 19739265 12594235 2444490 19416960 19923254
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0815131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.3911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3712903497
MESH:D005234 Fatty Liver arsenic trioxide 8.8515073043
MESH:D005234 Fatty Liver Cyclosporine 8.8519224547
MESH:D005355 Fibrosis Cyclosporine 3.5612168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006529 Hepatomegaly Phenobarbital 3.9016109766
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007333 Insulin Resistance Sodium Selenite 3.4714714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.3412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.348314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816968895 16467208 17050201 19850784 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4116330433 17217047 17107899 17869043 12712474 11161223 11468182 15622746 16112521 17649720 9834237 15213294 17712046 19075265 19642359 16966277 19035177 16891316 19225113 12018890 16331271 16823087 15336539 15748426 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008107 Liver Diseases Acetaminophen 4.1516610002 12969438 19784758 19014921 11587558 19460945 16611625 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.1519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.092125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 8.0914682389
MESH:D008113 Liver Neoplasms Phenobarbital 8.0915975961 8742319 19812893 21047994 19482888 19073162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.998603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.9920377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.996150874 1399818 17172636 18308698 2563599
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.6014755239
MESH:D008175 Lung Neoplasms arsenic trioxide 2.6019825857 11798837
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3215949261 19549372 19417148 14977855 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016882451 16105982
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3110525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4812452020 19769630 16624393
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6115580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6116965848
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D011230 Precancerous Conditions Cyclosporine 9.9412371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.942563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2619131511
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2618760546
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012640 Seizures Phenobarbital 2.893137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.0319014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.031399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5811780464 20435036 12973940 12845720
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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