AutismKB 2.0

Annotation Detail for PHIP


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Basic Information Top
Gene Symbol:PHIP ( DCAF14,FLJ20705,FLJ45918,MGC90216,WDR11,ndrp )
Gene Full Name: pleckstrin homology domain interacting protein
Band: 6q14.1
Quick LinksEntrez ID:55023; OMIM: 612870; Uniprot ID:PHIP_HUMAN; ENSEMBL ID: ENSG00000146247; HGNC ID: 15673
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003010 Clorgyline Clorgyline results in increased expression of PHIP mRNAincreases expression 19691856
D002945 Cisplatin PHIP protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of PHIP mRNA]affects reaction|decreases expression 15016801
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PHIP mRNAdecreases expression 18691609
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4714514962 15322242 11752688
MESH:D058186 Acute Kidney Injury Cisplatin 4.3815814532 17670903 12690470
MESH:D000230 Adenocarcinoma Cisplatin 4.9517638652 11798837
MESH:D000230 Adenocarcinoma Fluorouracil 4.9517638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Fluorouracil 10.0215504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 10.0211748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.6114601052
MESH:D001943 Breast Neoplasms Cisplatin 1.9419526202 18382427
MESH:D001943 Breast Neoplasms Fluorouracil 1.9415136595 19217205 18357371 16557594 16110121 16595493 18608205
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.3916051944
MESH:D002277 Carcinoma Fluorouracil 9.2917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.2916835633
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 3.4717982673
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.4717045692 17971768 17088986 18930000 16799960 16332177
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1416685392 12023789
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1718695887
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.236189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.2316280240 17066447 18986760 16757204
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2412621046 15340226 16354765 8697196 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2815001691 17172411 16510598 17169374 17725105 18772588 16340194 17018589 17016597 17287894
MESH:D015179 Colorectal Neoplasms Cisplatin 2.7915273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7914970324 15148649 17016601 17695437 18288408 18802399 16391804 18383874 15289873 18509181 18448328 16303861 17094418 16282729 16331619 20501625 17594712 17454858 18949393 17401013 17255274 16524972
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 5.4216733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Cisplatin 9.1612649298 19839026 15033597 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 9.1611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.429294722 10568697
MESH:D004938 Esophageal Neoplasms Cisplatin 5.0415464296 17638652 15173087 16481741 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 5.0417638652 15173087 16785472 16337965 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D005910 Glioma Fluorouracil 2.9916145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 8.8415102660 15464296
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.8415162350 15102660 18337622
MESH:D034381 Hearing Loss Cisplatin 4.6719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.7715464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 12621046 16120746
MESH:D006689 Hodgkin Disease Cisplatin 3.9616200630 16170182
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.778697196 18606429 15340226 16959395 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.8615464296
MESH:D007674 Kidney Diseases Cisplatin 3.4415190930 18289764 12649298 19839026 12231392
MESH:D007680 Kidney Neoplasms Fluorouracil 3.6516985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.5211231351
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Fluorouracil 4.9015113037 18383874 16603448 17045692
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.9016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Cisplatin 3.6717225452 11798837 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 3.6715246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.4215086387
MESH:D008545 Melanoma Cisplatin 2.5111135225 18505091 18176117 15577323 12393984 16809738 18332650 16432458 12883367 16248763 12374674 17023156 17761969
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.4115990972
MESH:D008654 Mesothelioma Cisplatin 3.3717638057
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9418986760 16757204
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009369 Neoplasms Cisplatin 5.9116773208
MESH:D009369 Neoplasms Fluorouracil 5.9118600527 18239605 16928823
MESH:D009395 Nephritis, Interstitial Cisplatin 5.2115464296
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D009447 Neuroblastoma Cisplatin 3.628761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.338761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6916436463
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9715464296 6897625 19769630 17225452
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.9219003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.9216929163 15113037 19003803 16500647
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.8115464296
MESH:D010997 Pleural Neoplasms Cisplatin 6.0717638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211222880 11399792 11118676 11896295
MESH:D011471 Prostatic Neoplasms Clorgyline 3.6319691856
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.6318626508 19082440
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3815538739 18286688 18722050 16160472
MESH:D051437 Renal Insufficiency Cisplatin 4.9715464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.9314601052
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 6.0715464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.7815958060 18396642 17522103
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7818396642 16951190 16424979 17498489 17522103 19084572 18567086 15786421 17172411 19015929
MESH:D013736 Testicular Neoplasms Cisplatin 5.0915464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3816280240
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 3.0712973940 17225452 15464296
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.9916803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.9916803524
MESH:D014625 Vaginal Neoplasms Cisplatin 5.1715577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D014839 Vomiting Cisplatin 5.4411897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33265
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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