AutismKB 2.0

Annotation Detail for USP47


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Basic Information Top
Gene Symbol:USP47 ( DKFZp686C13257,FLJ20727,TRFP )
Gene Full Name: ubiquitin specific peptidase 47
Band: 11p15.3
Quick LinksEntrez ID:55031; OMIM: NA; Uniprot ID:UBP47_HUMAN; ENSEMBL ID: ENSG00000170242; HGNC ID: 20076
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of USP47 mRNAaffects expression 18281256
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of USP47 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of USP47 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of USP47 mRNAdecreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of USP47 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of USP47 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of USP47 mRNAincreases expression 20106945
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of USP47 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of USP47 mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of USP47 mRNAincreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of USP47 mRNAaffects expression 17440010
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of USP47 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of USP47 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.853712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.856695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.673581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.806135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.807505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.8020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.8012371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.229022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.2219486331
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.972524372 18759878 8156756 11906362 8970840 14531868 11298694 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.4421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.449653073 11289319 8291058 7440962 9022650 6679447 18692083 16192314 6482804 18648102 18289764 9328219 1440618
MESH:D056486 Drug-Induced Liver Injury Selenium 12.4415131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.4415131321
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.373581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3716530937
MESH:D005234 Fatty Liver Cyclosporine 2.9919224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Cyclosporine 3.3212639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9220471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9216080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 4.9316109766
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9617440010
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3614714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.249022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.278314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.2712488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.7516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.7516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.756582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.7512371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.657678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6521137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.176135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.176587162 598648 1399818 3712494
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4620464547 18816296 18520028 20135361 17053015 20869020 18569708 20064080 6695378
MESH:D008175 Lung Neoplasms Vitamin E 2.4611062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.007678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.8512819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.8516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.854026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5418760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5415084515
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4319755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.993712494 1399818 6587162 6582329 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.3216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.3216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.328074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.3217053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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