AutismKB 2.0

Annotation Detail for NOL8


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Basic Information Top
Gene Symbol:NOL8 ( C9orf34,DKFZp686P12242,FLJ20736,Nop132,bA62C3.3,bA62C3.4 )
Gene Full Name: nucleolar protein 8
Band: 9q22.31
Quick LinksEntrez ID:55035; OMIM: 611534; Uniprot ID:NOL8_HUMAN; ENSEMBL ID: ENSG00000198000; HGNC ID: 23387
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NOL8 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of NOL8 mRNAaffects expression 21346803
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NOL8 mRNAaffects cotreatment|affects expression 17602206
C030123 coumarin coumarin results in increased expression of NOL8 mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine results in increased expression of NOL8 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NOL8 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NOL8 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOL8 mRNAaffects cotreatment|increases expression 17942748
C010327 salinomycin salinomycin results in decreased expression of NOL8 mRNAdecreases expression 19682730
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of NOL8 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of NOL8 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOL8 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of NOL8 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of NOL8 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.147525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000236 Adenoma Diethylnitrosamine 2.9310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7119061943 17162532 16434500 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9817474063
MESH:D001943 Breast Neoplasms salinomycin 1.9819682730
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0516705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.0516540662 16328049 11831363 17138121 18978308 3084413 16569478 19171122 19822196 19701751 17055752 16807293 19208518 16502159 17162532 18506893 18494052 20084675 20101231 18785209 20214788 19052882 20007298 18210153 19383236 20514400 20432363 18788625 18971187 16878318 19107877 20727157 18691550 19919837 16681979 18393292 21159647 19394651 16698587 17761372 10737359 19335982 16779866 17173139 16830150 16288022 17428255 17978847 10672840 3581430 18665156 19539802 20935162 19519916 20512989 20524982 19418558 16935385 18056438
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18850075 18670907
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7114694615
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.9217174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis Cyclosporine 8.1219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1215861022 16105132 11677210 17681005 17110522 16919318 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.158697196 12621046 16354765 15340226 15668235
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.6115095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.6114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1918551238
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 7.3819647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.3820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3817107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.4421346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.4419107877
MESH:D056486 Drug-Induced Liver Injury Selenium 12.4415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.4420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 13.8919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.8921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 9.0712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8016080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0712621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 15340226 18606429 8697196 16354765
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Diethylnitrosamine 5.1218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1212878042 12200463
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.2718776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 6.2712488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918522880 19638242 20032147 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3816169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms Clofibric Acid 7.7417602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.7419812893 20583210 19690152 19256749 19426721 20434301 21278145 19254457 21047994 18977376 20452335 19255062 18754104 20501860 20405173 20118626 18644402 20101389 19294768 2422723 10737359 19996281 20137499 19833225 12771043 15175105 12112319 19427195 20492335 21071580 19499222 9163691 19638242 19642983 19551842 19850985 15885732 18648771 19073162 18978307 21167192 19090486 2862719 16942905
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7416984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.0418079962 19004024 3124819 18164116 19539802 17174075 16267830 17854601 17942915 18308698 18775883 18093689 18544905 19126423 19009564 9362446 18253720 18282651 16842330 19519916 21159647 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0412151625
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.476695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4719555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.4711062179
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 6.7519682730
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.7515318939
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0518551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5716049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.5714694615
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.3612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.362563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3316049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D014689 Venous Insufficiency coumarin 5.9912708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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