AutismKB 2.0

Annotation Detail for ZWILCH


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Basic Information Top
Gene Symbol:ZWILCH ( FLJ10036,FLJ16343,KNTC1AP,MGC111034,hZwilch )
Gene Full Name: Zwilch, kinetochore associated, homolog (Drosophila)
Band: 15q22.31
Quick LinksEntrez ID:55055; OMIM: 609984; Uniprot ID:ZWILC_HUMAN; ENSEMBL ID: ENSG00000174442; HGNC ID: 25468
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ZWILCH proteinaffects expression 20106945
C015001 arsenite arsenite results in decreased expression of ZWILCH mRNAdecreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ZWILCH mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZWILCH mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ZWILCH mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ZWILCH mRNAdecreases expression 20106945
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of ZWILCH mRNAincreases expression 20713471
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ZWILCH mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of ZWILCH mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of ZWILCH mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.246695378
MESH:D000236 Adenoma Methylcholanthrene 7.246695378 10545420
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0916434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5611922910
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3117474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.3117474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0416227642 10355542 15673190 15700767 15721981 16124888 16011737 16050911 18705752 3786805 16097048 16192424
MESH:D002277 Carcinoma Methylcholanthrene 4.1310545420
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7712619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7718788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.771701930 20935162 6705139 20007298 17173139
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.0420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.0412371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 12.0416192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D003110 Colonic Neoplasms arsenite 2.6115037631
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0921278145 7120509 10915739 16227642 2869522 3786805 15998439 17522070 9327722 19085960 15027814 19336974 6623471 7440962 6884620 16177239 7179309 15968718 10092053 4309450 3732212 11566570
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.1911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5016530937
MESH:D005234 Fatty Liver arsenite 20.5718296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.5715959796 12631006 17595544 19224547 16239168 16045604 12795759 61145
MESH:D005234 Fatty Liver Cyclosporine 20.5719224547
MESH:D005234 Fatty Liver pirinixic acid 20.5720131406 19236843
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.2210962813 14633661
MESH:D005355 Fibrosis arsenite 16.4418296743
MESH:D005355 Fibrosis Carbon Tetrachloride 16.4418705752
MESH:D005355 Fibrosis Cyclosporine 16.4412168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 9.3616109766
MESH:D006529 Hepatomegaly pirinixic acid 9.3619772884 16221962 18467677 19176532
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.448314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D008103 Liver Cirrhosis arsenite 11.7118296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.7111408273 17334410 17174718 21278145 16221502 16943688 16239168 11903743 17157831
MESH:D008103 Liver Cirrhosis Phenobarbital 11.7121047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3718279442 11481614 12667390 15362042 17525996 14716833 15996030 18705752 18395914 12632512 16027843 15673190 12958196 17708605 18251166 16136751 13678700 17565644 17640975 16033810 12586293 17698563 18156304 15338365 18429990 15370692 15876570 18339082 15818738 18472332 12898905 14748882 12741479 12389079 12445421 14620537 17714472 12632514 18412020 18166357 10355542 17922224 17721639 18317297 18418968 18006644 12546737 15057751 18205269 15893842 17557913 15925388 18376398 17631135 16116963 18263696 14512876 16011737 12666154 18277467 15650968 12609069 17823541 14724832 16248980 15730626 16638106 16192424 18210741 17869086 12445418 18481824 16015684 17481882 15052691 17766677 15931870 12649538 17976157 16097048 15959796 18420326 18395095 18472094 20821823 17761835 18187930 17805973 17944888 18054572 17900296 15123356 14716496
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3715474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2515830285 16964402 17285989 15720792 16246199
MESH:D008107 Liver Diseases Phenobarbital 4.2519363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8814706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.989163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.9821137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.9819294768
MESH:D008113 Liver Neoplasms Phenobarbital 14.988742319 19482888 15975961 21047994 19073162 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 14.9816377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.208603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.2012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 15.20598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.201399818 2563599 18308698 6150874 17172636
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0814755239
MESH:D008175 Lung Neoplasms arsenite 5.0816809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0818816296 6695378 18569708 20464547 20135361 20869020 20064080 18520028 17053015
MESH:D008175 Lung Neoplasms Methylcholanthrene 5.0810545420 20512841 7750092 20970405 15390079 16271038 11893704 6695378 1399818 21163286 16337739 17909032 9230183
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.7015738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5516965848
MESH:D011230 Precancerous Conditions Cyclosporine 9.5912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.592563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures Phenobarbital 2.8216876388 4039156 11442880 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.211399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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