AutismKB 2.0

Annotation Detail for PPP1R3C


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Basic Information Top
Gene Symbol:PPP1R3C ( PPP1R5 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 3C
Band: 10q23.32
Quick LinksEntrez ID:5507; OMIM: 602999; Uniprot ID:PPR3C_HUMAN; ENSEMBL ID: ENSG00000119938; HGNC ID: 9293
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PPP1R3C mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of PPP1R3C mRNAaffects expression 15606129
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PPP1R3C proteinaffects expression 20106945
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of PPP1R3C mRNAincreases expression 19194377
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PPP1R3C mRNAaffects cotreatment|decreases expression 15894712
C015001 arsenite arsenite results in decreased expression of PPP1R3C mRNAdecreases expression 15894712
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PPP1R3C mRNAaffects cotreatment|decreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PPP1R3C mRNAdecreases expression 15894712
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PPP1R3C mRNAincreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PPP1R3C mRNAdecreases expression 15336504
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PPP1R3C mRNAaffects cotreatment|affects expression 17602206
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in increased expression of PPP1R3C mRNAaffects binding|increases expression 20105288
C018021 cobaltous chloride cobaltous chloride results in increased expression of PPP1R3C mRNAincreases expression 20105288
D016572 Cyclosporine Cyclosporine results in decreased expression of PPP1R3C mRNAdecreases expression 20106945
C014347 decitabine [[decitabine co-treated with trichostatin A] affects the methylation of PPP1R3C promoter] which affects the expression of PPP1R3C mRNAaffects cotreatment|affects expression|affects methylation 18803327
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PPP1R3C mRNAincreases expression 19100860
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PPP1R3C mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PPP1R3C mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of PPP1R3C mRNAdecreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PPP1R3C mRNAincreases expression 17351261
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of PPP1R3C mRNAincreases expression 19100860
D017313 Fenretinide Fenretinide results in decreased expression of PPP1R3C mRNAdecreases expression 15958647
D010634 Phenobarbital Phenobarbital results in increased expression of PPP1R3C mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of PPP1R3C mRNAincreases expression 18445702
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PPP1R3C mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PPP1R3C mRNAdecreases expression 20106945
19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PPP1R3C mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PPP1R3C mRNAincreases expression 16267337
D013752 Tetracycline Tetracycline results in increased expression of PPP1R3C mRNAincreases expression 16917069
D014212 Tretinoin Tretinoin results in decreased expression of PPP1R3C mRNAdecreases expression 16249480
C012589 trichostatin A [[decitabine co-treated with trichostatin A] affects the methylation of PPP1R3C promoter] which affects the expression of PPP1R3C mRNAaffects cotreatment|affects expression|affects methylation 18803327
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in increased expression of PPP1R3C mRNAaffects binding|increases expression 20105288
C081489 valsartan valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA]decreases expression|decreases reaction 19225232
C025643 vinclozolin vinclozolin affects the expression of PPP1R3C mRNAaffects expression 19015723
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of PPP1R3C mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.486195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4815322242 14514962 11752688
MESH:D000138 Acidosis Zinc Sulfate 4.667265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.6520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.6511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.6514692618
MESH:D000230 Adenocarcinoma Fenretinide 9.6510697514
MESH:D000236 Adenoma Benzo(a)pyrene 10.446695378
MESH:D000236 Adenoma Diethylnitrosamine 10.4410737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 10.446695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.8216434500 17620307 17162532 19052882 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.8217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.8216835633
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D000860 Anoxia Zinc Sulfate 4.777265320
MESH:D001008 Anxiety Disorders vinclozolin 3.4519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.9912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.9916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6714991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 8.5916436596 15144691 16651633 18412241 16357521
MESH:D001932 Brain Neoplasms Fenretinide 8.5916187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.5320146248 17474063
MESH:D001943 Breast Neoplasms Cobalt 4.5315986119
MESH:D001943 Breast Neoplasms decitabine 4.5318320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.5317474063
MESH:D001943 Breast Neoplasms Estradiol 4.5317289903 18497071 19861407 16675129 14630087 17018787 12948864 17261762
MESH:D001943 Breast Neoplasms Fenretinide 4.5316601279
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5320435547
MESH:D001943 Breast Neoplasms Tretinoin 4.5316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.443084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.4421507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.4418971187 19701751 16681979 3581430 18691550 19335982 17055752 19394651 19919837 19171122 19418558 19107877 19052882 19383236 16935385 17138121 20214788 16698587 20727157 20007298 18788625 16288022 18393292 17428255 16328049 11831363 20514400 19822196 16502159 20935162 18506893 16540662 18665156 16830150 16569478 18494052 16878318 20101231 10672840 19539802 18056438 20524982 18210153 18785209 19208518 17978847 17761372 16807293 10737359 20512989 20432363 16779866 3084413 18978308 17173139 19519916 21159647 17162532 20084675
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.4416924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 13.4417159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.441701930 17173139 6705139 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.441917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.2220419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.2219215824
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 10.2216274795
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.2216051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6718850075 18670907 16120746
MESH:D006332 Cardiomegaly valsartan 6.6719597038
MESH:D009202 Cardiomyopathies valsartan 4.2816247790
MESH:D002318 Cardiovascular Diseases valsartan 4.1311230374
MESH:D002386 Cataract Acetaminophen 6.7510977129
MESH:D002386 Cataract Tretinoin 6.7517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.3220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.3212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.3221159647 2727394 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.3218566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 19.3216003739
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.014080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7317160924
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 12.1516154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 12.1516129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D002779 Cholestasis Cyclosporine 12.3019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3016105132 15861022 16919318 17681005 11677210 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 12.3019176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4216354765 15668235 12621046 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Tretinoin 3.4617035595
MESH:D003110 Colonic Neoplasms arsenite 3.8415037631
MESH:D003110 Colonic Neoplasms decitabine 3.8417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.8318981723
MESH:D015179 Colorectal Neoplasms Fenretinide 2.8317273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D003324 Coronary Artery Disease valsartan 3.8117719468
MESH:D003384 Coxsackievirus Infections valsartan 5.6020392896
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3715322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.379125849 16925845 8800419 9224671 17551590 14991402 10589399 9142499 9211117 9664655
MESH:D003456 Cryptorchidism vinclozolin 4.1114966744
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 3.8016823706 11298694 15059100
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.4011508273
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0117107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.6419279558
MESH:D003928 Diabetic Nephropathies valsartan 8.6411427623 18630688
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.3611743745 19923254 14725611 19420014 11739529 16177239 18713872 19085960 12392966 15968718 15619225 16227642 14550746 17522070 10663392 19164858 10774834 12958197 19370779 17906064 17562736 16109766 11529661 12705907 16781746 11287661 16485898 2444490 19739265 18071297 16393943 12594235 12540782 11834606 19416960 10915739 12153990 11421492 11461765 16081117 14986274
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.3619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3620420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 8.3617522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004421 Dystonia Phenobarbital 3.781851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7318357618
MESH:D004487 Edema pirinixic acid 5.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9512538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.2019294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.2019294695
MESH:D016889 Endometrial Neoplasms Estradiol 6.8911473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.8916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6211558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.346401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.773659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.249664655 16938888
MESH:D005234 Fatty Liver arsenite 27.8518296743
MESH:D005234 Fatty Liver Cyclosporine 27.8519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 27.8520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.8515345470
MESH:D005234 Fatty Liver pirinixic acid 27.8520131406 19236843
MESH:D005234 Fatty Liver Tetracycline 27.8519224547 16917069
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005355 Fibrosis arsenite 25.1818296743
MESH:D005355 Fibrosis Cyclosporine 25.1812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.1820067830
MESH:D005355 Fibrosis Tretinoin 25.1817994277
MESH:D005355 Fibrosis valsartan 25.1816893502
MESH:D005756 Gastritis Acetaminophen 3.4316983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0516417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Ethylnitrosourea 15.7516436596
MESH:D005909 Glioblastoma Fenretinide 15.7516187019
MESH:D005909 Glioblastoma Tretinoin 15.7517312396
MESH:D005909 Glioblastoma trichostatin A 15.7518801729
MESH:D005910 Glioma Ethylnitrosourea 3.4016651633 16357521 18412241
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.3116928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.2919215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.3420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.3410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.349664655 14991402
MESH:D006333 Heart Failure pirinixic acid 6.8920558911
MESH:D006333 Heart Failure valsartan 6.8919027736
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 4.7617063115
MESH:D006529 Hepatomegaly Phenobarbital 12.9816109766
MESH:D006529 Hepatomegaly pirinixic acid 12.9818467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.9815340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.808697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.9916870215
MESH:D006930 Hyperalgesia Tretinoin 6.9916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D006973 Hypertension Cobalt 11.6917039479
MESH:D006973 Hypertension Cyclosporine 11.6910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.6918850075 18670907
MESH:D006973 Hypertension valsartan 11.6912692753 12850387 16475468 20102058 18390891 18344623 10903974 11427623
MESH:D006974 Hypertension, Malignant valsartan 6.1611560862
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716569931 16945680
MESH:D007022 Hypotension Zinc Sulfate 4.257265320
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male decitabine 10.3017581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.3017937319
MESH:D007248 Infertility, Male vinclozolin 10.3016467254
MESH:D007249 Inflammation Diethylnitrosamine 4.4818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.4812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.6716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.6716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2017551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Acetaminophen 13.3112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.318314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 13.3115618244
MESH:D007674 Kidney Diseases valsartan 13.3110903974 16893502 12164870
MESH:D007680 Kidney Neoplasms Cyclosporine 11.3512371664
MESH:D007680 Kidney Neoplasms Estradiol 11.3515610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 11.3517379185
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.0615237267
MESH:D007938 Leukemia decitabine 6.0218980019 19235587
MESH:D007938 Leukemia Tretinoin 6.0217143497
MESH:D007951 Leukemia, Myeloid decitabine 8.8319117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 8.8316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.9718460780 19387464 17679729 18206229 19010910 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.9717596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 5.9718206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2118055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9919035177 17506722 19642359 16891316 16788101 17217047 16823087 12679006 17294898 17361223 15748426 16935935 17712046 19075265 16766008 19225113 17368321 16140955 16331271 19029980 9834237 17301526 17107899 17649720 17339181
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7916707609
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4816417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008103 Liver Cirrhosis arsenite 10.3218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3219638242 18522880 18407596 18665156 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3221047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4016248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental valsartan 6.4016872305 15619341 15504291
MESH:D008107 Liver Diseases Acetaminophen 6.0916611625 19460945 19784758 19014921 12969438 12587719 16610002 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.0917034775
MESH:D008107 Liver Diseases Phenobarbital 6.0919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0216871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.4515890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.4520195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 20.4517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.4519642983 20137499 19294768 19690152 19812893 19427195 2862719 9163691 21278145 19426721 21071580 12771043 18977376 19996281 18754104 19850985 18644402 19256749 19254457 12112319 20501860 21167192 2422723 19255062 19090486 20434301 20101389 19499222 18978307 21047994 20118626 19638242 20452335 15885732 19551842 20405173 18648771 20583210 15175105 20492335 19833225 10737359 19073162 16942905
MESH:D008113 Liver Neoplasms Phenobarbital 20.458742319 19073162 21047994 15975961 19482888 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 20.4520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.4516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.868603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.8618775883 17942915 19539802 18282651 18544905 21159647 16267830 18093689 2563599 19519916 18079962 17854601 9362446 18164116 19009564 3124819 19004024 16842330 17174075 18308698 18253720 19126423
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.866150874 17172636 2563599 18308698 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.8612151625
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.626434250
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.1414755239
MESH:D008175 Lung Neoplasms arsenite 8.1416809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.1418520028 18816296 17053015 20064080 18569708 6695378 20464547 20135361 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.1420970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Ethylnitrosourea 8.146695378 16019985 17703301 16271038
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1411884234 19555203
MESH:D008223 Lymphoma decitabine 7.3319470736
MESH:D008223 Lymphoma Ethylnitrosourea 7.3315790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.8115375218
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.2816891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 9.2810838139 18041768 10767621
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 9.2810697514
MESH:D020149 Manganese Poisoning Estradiol 4.2319453300
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma decitabine 7.0017785578 16505122
MESH:D008545 Melanoma Fenretinide 7.0016270382
MESH:D008545 Melanoma Tretinoin 7.0016752155
MESH:D008545 Melanoma trichostatin A 7.0016505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008579 Meningioma Ethylnitrosourea 5.7317943659
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D009041 Motion Sickness Dextroamphetamine 5.271613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.1616381670
MESH:D009062 Mouth Neoplasms Fenretinide 8.1616274795
MESH:D009101 Multiple Myeloma decitabine 7.0818172295
MESH:D009101 Multiple Myeloma trichostatin A 7.0818172295
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009190 Myelodysplastic Syndromes decitabine 7.0219010910 19157545 18608210 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2317484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.479029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 14.4411141357
MESH:D009369 Neoplasms decitabine 14.4417925555 19470736 19116145
MESH:D009369 Neoplasms Fenretinide 14.4415958647 17353921
MESH:D009369 Neoplasms pirinixic acid 14.4417405874
MESH:D009369 Neoplasms Tretinoin 14.4416946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.1616707424
MESH:D009389 Neovascularization, Pathologic arsenite 9.3315738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.3317289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.549884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 14.9711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.9714600291
MESH:D009421 Nervous System Malformations Tretinoin 14.979125849
MESH:D009436 Neural Tube Defects Tretinoin 2.909142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.1717160924 16003739 16651423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4316303764
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7317160924
MESH:D010018 Osteomalacia Phenobarbital 4.1217016548
MESH:D010051 Ovarian Neoplasms decitabine 14.1619259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 14.1619401270
MESH:D010051 Ovarian Neoplasms Fenretinide 14.1616133793
MESH:D010051 Ovarian Neoplasms Tretinoin 14.1616936753
MESH:D010051 Ovarian Neoplasms trichostatin A 14.1619331143
MESH:D010146 Pain Acetaminophen 5.9416870215
MESH:D010146 Pain Tretinoin 5.9416870215
MESH:D010190 Pancreatic Neoplasms decitabine 19.3519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 19.3516540662
MESH:D010190 Pancreatic Neoplasms Fenretinide 19.3515580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 19.3516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 19.3515976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 19.3519294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.1811026799
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.0812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.082563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.082563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6711896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.6719015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 11.6217616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.6217616702
MESH:D017096 Prion Diseases Tetracycline 5.1710903871
MESH:D011469 Prostatic Diseases vinclozolin 4.6918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1817292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1816740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.1817024972
MESH:D011471 Prostatic Neoplasms trichostatin A 2.1818798265 19789329
MESH:D011472 Prostatitis vinclozolin 4.6918629315
MESH:D011507 Proteinuria Tretinoin 8.8316636307
MESH:D011507 Proteinuria valsartan 8.8317664856 18344623 12164870
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.2512752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011658 Pulmonary Fibrosis Cobalt 6.286434250
MESH:D011658 Pulmonary Fibrosis valsartan 6.2817241526
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012162 Retinal Degeneration Fenretinide 4.2216303925
MESH:D012208 Rhabdomyosarcoma decitabine 10.1919155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.1916116481 16283617
MESH:D012640 Seizures Phenobarbital 2.533137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.576407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.7010029692 19755658
MESH:D012878 Skin Neoplasms Fenretinide 16.7016467112
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.708532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.7016192470
MESH:D012878 Skin Neoplasms Tretinoin 16.7016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6916709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.502093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.5019037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5018456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.5017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.9115790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms decitabine 15.6017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.607505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.601399818
MESH:D013964 Thyroid Neoplasms Tretinoin 15.6016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5716051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.8917053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.8917616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 7.8916720286
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 8.9916154183
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014604 Uveal Neoplasms decitabine 12.0017785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.0016752155
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D020257 Ventricular Remodeling valsartan 5.4519027736
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
KEGG:04910 Insulin signaling pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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