AutismKB 2.0

Annotation Detail for TMEM45A


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Basic Information Top
Gene Symbol:TMEM45A ( DERP7,FLJ10134 )
Gene Full Name: transmembrane protein 45A
Band: 3q12.2
Quick LinksEntrez ID:55076; OMIM: NA; Uniprot ID:TM45A_HUMAN; ENSEMBL ID: ENSG00000181458; HGNC ID: 25480
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TMEM45A mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of TMEM45A mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TMEM45A mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of TMEM45A mRNAincreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TMEM45A mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of TMEM45A mRNAincreases expression 19619570
D011794 Quercetin Quercetin results in increased expression of TMEM45A mRNAincreases expression 19729006
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TMEM45A mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TMEM45A mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TMEM45A mRNAincreases expression 19933214
15667827
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 11752688 15322242
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.5217084956
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001260 Ataxia Telangiectasia Quercetin 5.3715336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Quercetin 4.7719761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Estradiol 1.8718497071 12948864 14630087 16675129 19861407 17261762 17289903 17018787
MESH:D001943 Breast Neoplasms Quercetin 1.8718628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002105 Cadmium Poisoning Quercetin 5.9916962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1415673190 16097048 15700767 16011737 15721981 3786805 10355542 18705752 16227642 16124888 16050911 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.873084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8716924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.8712508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.3117234771
MESH:D006332 Cardiomegaly Quercetin 7.2619794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.2618670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.208697196 15340226 12621046 15668235 16354765
MESH:D003110 Colonic Neoplasms Quercetin 2.4511134977 17191121 17148506 15741050 19440933 16640504 19056647
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.9719496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5316177239 11529661 11739529 17906064 16081117 16781746 19420014 19416960 10663392 12958197 12153990 12705907 16227642 14725611 17562736 10915739 12594235 19739265 11743745 14550746 17522070 12540782 19370779 18071297 11834606 11287661 16109766 11461765 16485898 14986274 12392966 16393943 19085960 10774834 11421492 19164858 15619225 15968718 19923254 2444490 18713872
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5315968718 10092053 7120509 10915739 17522070 15027814 3732212 7179309 4309450 15998439 7440962 11566570 16177239 2869522 3786805 6623471 19085960 19336974 9327722 21278145 16227642 6884620
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.1511473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.6615959796 16045604 17595544 12631006 16239168 19224547 61145 12795759
MESH:D005234 Fatty Liver Cyclosporine 8.6619224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 24.4018705752
MESH:D005355 Fibrosis Cyclosporine 24.4012168785 12639820
MESH:D005355 Fibrosis Quercetin 24.4019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.4020067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Quercetin 3.5619804834
MESH:D005910 Glioma Quercetin 3.1417643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2516120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 16354765 15340226 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006943 Hyperglycemia Quercetin 4.3011834736 18262572
MESH:D006973 Hypertension Cyclosporine 9.1010903974
MESH:D006973 Hypertension Quercetin 9.1018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.1018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.9516624496
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007627 Keloid Quercetin 5.3117086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 15.6512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 15.658314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 15.6515618244
MESH:D007674 Kidney Diseases Quercetin 15.6516962696
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D007680 Kidney Neoplasms Estradiol 8.0615610895
MESH:D007938 Leukemia Quercetin 3.2717468513
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9417174718 11903743 16221502 16239168 11408273 21278145 17334410 17157831 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1815876570 18166357 18418968 18317297 18412020 20821823 18279442 14512876 18187930 18006644 12632512 12546737 12586293 15931870 16027843 14716496 18156304 16097048 15996030 18277467 10355542 16136751 12741479 14620537 16192424 16033810 15123356 16011737 18251166 15673190 13678700 18472094 12667390 12649538 17766677 18481824 17640975 12609069 18376398 11481614 18395914 17976157 18429990 12445418 18339082 18472332 17631135 17869086 17714472 18705752 12445421 17557913 17525996 15338365 12958196 17823541 15362042 12632514 18205269 12898905 15818738 18054572 17721639 15057751 15959796 16015684 17805973 12389079 16248980 17761835 17565644 14748882 17922224 17944888 17698563 15925388 18210741 17900296 17708605 12666154 15052691 18420326 15893842 15650968 16116963 16638106 15370692 17481882 15730626 18395095 14716833 18263696 14724832
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.1812741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1812878042
MESH:D008107 Liver Diseases Acetaminophen 4.0919460945 12969438 19014921 11587558 19784758 16611625 12587719 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0916246199 15830285 17285989 15720792 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.3116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.3114706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9719294768
MESH:D008113 Liver Neoplasms Quercetin 7.9718980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.8115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.8119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8112151625
MESH:D008175 Lung Neoplasms Quercetin 2.4816280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4819555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7216891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009203 Myocardial Infarction Quercetin 3.0919595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.2716810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.2719207477
MESH:D009369 Neoplasms Quercetin 2.9115185748
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.5816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.6717929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.5219495926
MESH:D010051 Ovarian Neoplasms Estradiol 5.1919401270
MESH:D010051 Ovarian Neoplasms Quercetin 5.1919005980
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9316965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.9412371664
MESH:D011230 Precancerous Conditions Quercetin 9.9419056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2816740699
MESH:D011471 Prostatic Neoplasms Quercetin 3.2817292933 14715546
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012554 Schistosomiasis japonica Quercetin 5.9916862918
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.8916720314
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134868262
    • No data
    Releated disease ID Related disease Name
    PA443434Arthritis, Rheumatoid
    Releated drug ID Related drug Name
    PA10004adalimumab
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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