AutismKB 2.0

Annotation Detail for TMEM51


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Basic Information Top
Gene Symbol:TMEM51 ( C1orf72,FLJ10199 )
Gene Full Name: transmembrane protein 51
Band: 1p36.21
Quick LinksEntrez ID:55092; OMIM: NA; Uniprot ID:TMM51_HUMAN; ENSEMBL ID: ENSG00000171729; HGNC ID: 25488
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TMEM51 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMEM51 mRNAdecreases expression 20382639
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TMEM51 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of TMEM51 mRNAincreases expression 19270015
19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.186195326
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.7117620307
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.033084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.036705139 1701930 20007298 17173139 20935162
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.0120889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.904080065
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6812392966 17906064 15968718 18071297 16227642 14550746 10774834 16781746 17522070 19420014 16177239 14725611 14986274 19164858 19085960 10915739 16081117 11739529 15619225 12540782 11834606 12153990 16109766 19370779 12958197 2444490 11421492 11743745 16485898 19416960 12705907 18713872 11461765 11529661 19739265 10663392 19923254 16393943 17562736 11287661 12594235
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004421 Dystonia Phenobarbital 4.531851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.763659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.7411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.966401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.907750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.763659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006529 Hepatomegaly Phenobarbital 4.1316109766
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D008103 Liver Cirrhosis Phenobarbital 3.1021047994
MESH:D008107 Liver Diseases Acetaminophen 4.2219460945 12969438 19784758 19014921 16611625 12587719 16610002 11587558
MESH:D008107 Liver Diseases Phenobarbital 4.2219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 2.438742319 19073162 19482888 19812893 15975961 21047994
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.9518308698 17172636 1399818 2563599 6150874
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.2217484760
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D010018 Osteomalacia Phenobarbital 5.1117016548
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6116965848
MESH:D011230 Precancerous Conditions Phenobarbital 4.042563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.3612752131
MESH:D012640 Seizures Phenobarbital 2.974039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.566407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.391399818
MESH:D014581 Urticaria Acetaminophen 3.5010982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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