AutismKB 2.0

Annotation Detail for RALGPS2


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Basic Information Top
Gene Symbol:RALGPS2 ( FLJ10244,FLJ25604,KIAA0351,dJ595C2.1 )
Gene Full Name: Ral GEF with PH domain and SH3 binding motif 2
Band: 1q25.2
Quick LinksEntrez ID:55103; OMIM: NA; Uniprot ID:RGPS2_HUMAN; ENSEMBL ID: ENSG00000116191; HGNC ID: 30279
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RALGPS2 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RALGPS2 mRNAdecreases expression 19150397
D002117 Calcitriol Calcitriol results in increased expression of RALGPS2 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RALGPS2 mRNAincreases expression 17555576
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of RALGPS2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of RALGPS2 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of RALGPS2 mRNAincreases expression 18301758
D014635 Valproic Acid Valproic Acid results in increased expression of RALGPS2 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of RALGPS2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.686195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2716434500
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders Valproic Acid 9.5017497229
MESH:D001008 Anxiety Disorders vinclozolin 9.5019015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618558336 18940202 18985861 17157402 20603192 17507914 18316065 18177632 18396377 16609825 15238991 17688650 19460635 19232924 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001943 Breast Neoplasms Calcitriol 2.5811237771
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.9717173139 1701930 20935162 20007298 6705139
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6811237771
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3317110522 16105132 17333356 16919318 15861022 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 8.3319176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9918713872 14725611 19420014 16227642 19370779 11461765 11743745 11834606 11739529 17906064 16393943 14550746 12594235 12705907 12153990 18071297 15968718 19739265 16081117 11421492 12392966 14986274 19085960 11529661 10663392 16781746 17562736 19416960 15619225 10915739 10774834 12958197 19923254 12540782 2444490 11287661 16177239 17522070 19164858 16109766 16485898
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9919641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004421 Dystonia Phenobarbital 11.321851702
MESH:D004421 Dystonia Valproic Acid 11.321851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 10.0515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0512538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.843659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.843659116 17275665
MESH:D004828 Epilepsies, Partial Phenobarbital 11.2611558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 11.263922381 16628512
MESH:D004827 Epilepsy Phenobarbital 7.0320417680
MESH:D004827 Epilepsy Valproic Acid 7.0318234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 9.596401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.597562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 12.357750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 12.357750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.633659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.633659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5215345470
MESH:D005234 Fatty Liver pirinixic acid 14.5220131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 14.5219224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4118558336 8888407
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly Phenobarbital 9.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.5218467677 16221962 19176532 19772884
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1717937319
MESH:D007248 Infertility, Male vinclozolin 7.1716467254
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1019460945 16610002 19784758 12969438 19014921 16611625 11587558 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.1019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.7219482888 15975961 8742319 19073162 21047994 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 4.7215890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.841399818 6150874 18308698 2563599 17172636
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.278888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.8720603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.8719015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5018247401 15754350 16644109 16289102 12479363
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 13.4812752131
MESH:D019310 Pseudolymphoma Valproic Acid 13.4812752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Phenobarbital 6.5316876388 3137016 4039156 11442880
MESH:D012640 Seizures Valproic Acid 6.5311044598 15475178 16876388 17978042 3137016 11738929 1511512 14763951
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134864387
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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