AutismKB 2.0

Annotation Detail for AGGF1


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Basic Information Top
Gene Symbol:AGGF1 ( FLJ10283,GPATC7,GPATCH7,HSU84971,HUS84971,VG5Q )
Gene Full Name: angiogenic factor with G patch and FHA domains 1
Band: 5q13.3
Quick LinksEntrez ID:55109; OMIM: 608464; Uniprot ID:AGGF1_HUMAN; ENSEMBL ID: ENSG00000164252; HGNC ID: 24684
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AGGF1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AGGF1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of AGGF1 mRNAaffects expression 18648102
D001374 Azacitidine Azacitidine results in increased expression of AGGF1 mRNAincreases expression 19194470
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of AGGF1 mRNAdecreases expression 20127859
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AGGF1 mRNAaffects binding|decreases expression|increases activity 19710929
C004648 testosterone enanthate testosterone enanthate affects the expression of AGGF1 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.093712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.096695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.767296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.277505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.529022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1512868966 8156756 11906362 11298694 14531868 18759878 8970840 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.636679447 9022650 18692083 7440962 9328219 8291058 11289319 18648102 18289764 9653073 6482804 1440618 16192314
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5616530937
MESH:D005234 Fatty Liver pirinixic acid 3.0419236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3519772884 16221962 18467677 19176532
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1917440010
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.8016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.8016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.806582329
MESH:D007715 Klippel-Trenaunay-Weber Syndrome marker/mechanism
MESH:D007938 Leukemia Azacitidine 3.8119148494
MESH:D007951 Leukemia, Myeloid Azacitidine 4.9019077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 3.0317596541 18720364
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.5019299654
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.897678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8921137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.8915890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.432876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.43598648 1399818 3712494 6587162
MESH:D008175 Lung Neoplasms Azacitidine 2.7921224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.7920464547 6695378 17053015 20064080 18816296 18520028 18569708 20135361 20869020
MESH:D009006 Monosomy Azacitidine 6.5319299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009101 Multiple Myeloma Azacitidine 4.1619549372 18443271
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 4.1418720364 19805378 17596541 17611569
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.707678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2211141357
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.6612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.6616049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.666482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011471 Prostatic Neoplasms Azacitidine 3.4318324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4317292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4819755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.091399818 3712494 6587162 7505956 6582329
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.6816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.6816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.688074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.6817053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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