AutismKB 2.0

Annotation Detail for PPP1R8


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Basic Information Top
Gene Symbol:PPP1R8 ( ARD-1,ARD1,NIPP-1,NIPP1,PRO2047 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 8
Band: 1p35.3
Quick LinksEntrez ID:5511; OMIM: 602636; Uniprot ID:PP1R8_HUMAN; ENSEMBL ID: ENSG00000117751; HGNC ID: 9296
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PPP1R8 mRNAaffects expression 21346803
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PPP1R8 mRNAdecreases expression 12419474
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PPP1R8 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PPP1R8 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPP1R8 mRNAaffects cotreatment|increases expression 17942748
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of PPP1R8 mRNAdecreases expression 12419474
C017947 sodium arsenite sodium arsenite results in increased expression of PPP1R8 proteinincreases expression 19072884
D013629 Tamoxifen Tamoxifen affects the expression of PPP1R8 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPP1R8 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid Valproic Acid results in decreased expression of PPP1R8 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4611752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.468875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2816712894 17306315
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Valproic Acid 1.9917688650 15238991 18177632 20603192 17157402 18316065 16609825 19232924 18775368 18985861 17507914 18940202 18558336 19460635 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.508888407
MESH:D001943 Breast Neoplasms Tamoxifen 1.9419059307 18629630 20390343 19487384 11161223 19189212 16273361 19221464 19200415 18351453 19289846 18815881 17242785 17893378 20859285 20544844 18997820 19011961 19244106 17440819 18821012 21138602 17261762 15565566 20135344 15668708 20065188 19115204 21152245 16202921 20005174 19084267 18984771 19142967 16818667 19189210 19288272 19410462 19066611 17049068 19155303 18855134 19103187 18425577 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.7815276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7816924424
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.6716936243
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.286135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.2819524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517333356 17681005 11677210 16105132 17110522 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 15668235 8697196 16354765 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5317688650 16575769 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.551733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.9019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1916202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.807562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5715345470
MESH:D005234 Fatty Liver Tamoxifen 14.5714986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 14.5719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4118558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0216452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.3612676792
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 18606429 15340226 16354765 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1617937319
MESH:D007248 Infertility, Male sodium arsenite 7.1615346721 12646999
MESH:D007249 Inflammation Tamoxifen 5.2619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases sodium arsenite 2.9220008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.5216518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0716705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.0718625569
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008064 Lipidoses Tamoxifen 3.3215342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.357678174
MESH:D008113 Liver Neoplasms sodium arsenite 11.3515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 11.3516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.206135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D008171 Lung Diseases sodium arsenite 3.3219095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms sodium arsenite 3.5117306315 15276417 17077188 19931552 16712894
MESH:D008175 Lung Neoplasms Tamoxifen 3.5118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5111884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7611731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma sodium arsenite 3.4316487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.4319393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.207678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms sodium arsenite 2.6011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9720056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819200415 19189210 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects sodium arsenite 7.8312854658
MESH:D009436 Neural Tube Defects Valproic Acid 7.838888407 16359493
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4917306315 15276417
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.3912065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6111222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.6120603192
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2016039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012640 Seizures Valproic Acid 6.4711044598 15475178 14763951 16876388 3137016 17978042 1511512 11738929
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 14.4212065085
MESH:D012878 Skin Neoplasms sodium arsenite 14.4219524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.428532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.4216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D016135 Spinal Dysraphism sodium arsenite 10.1612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 10.1619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8016049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.8016452187 16712894 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.8017572228 16712894 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9911813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014652 Vascular Diseases sodium arsenite 4.7617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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