AutismKB 2.0

Annotation Detail for PRPF38B


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Basic Information Top
Gene Symbol:PRPF38B ( FLJ10330,MGC163218,MGC41809,NET1,RP11-293A10.1 )
Gene Full Name: PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
Band: 1p13.3
Quick LinksEntrez ID:55119; OMIM: NA; Uniprot ID:PR38B_HUMAN; ENSEMBL ID: ENSG00000134186; HGNC ID: 25512
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PRPF38B mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PRPF38B mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRPF38B mRNAdecreases expression 20018196
D003024 Clozapine Clozapine results in decreased expression of PRPF38B mRNAdecreases expression 14647396
D006220 Haloperidol Haloperidol results in decreased expression of PRPF38B mRNAdecreases expression 14647396
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D000380 Agranulocytosis Clozapine 5.5414617031 12649775 16160616
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1319368416 18080171
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.943581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002375 Catalepsy Haloperidol 5.4515215559 1977408
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.437505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4320889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.419022650 19486331
MESH:D003072 Cognition Disorders Clozapine 5.4517123785
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.2520210726
MESH:D003704 Dementia Haloperidol 4.9511575062
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2818759878 14531868 2524372 11298694 12868966 8156756 11906362 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0416402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 6.1715331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.999022650 11289319 8291058 9653073 7440962 18648102 1440618 6482804 16192314 18692083 9328219 18289764 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9919370779 18071297 12540782 11834606 12594235 14725611 19164858 12705907 14550746 12958197 11529661 10663392 19420014 19739265 16081117 16781746 10774834 11287661 12392966 17906064 16393943 10915739 17562736 16227642 18713872 11421492 16485898 19416960 11743745 11461765 11739529 14986274 16177239 12153990 19923254 17522070 2444490 19085960 16109766 15619225 15968718
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D050171 Dyslipidemias Clozapine 4.4316402076
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.633581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6320426865
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006948 Hyperkinesis Clozapine 5.4516046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D008064 Lipidoses Clozapine 4.2117567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6912587719 16611625 12969438 16610002 19784758 11587558 19014921 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.73598648 6587162 1399818 3712494
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D001523 Mental Disorders Clozapine 10.2216856516
MESH:D001523 Mental Disorders Haloperidol 10.2216856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.7219142101
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity Clozapine 3.0818515891 19142110
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011595 Psychomotor Agitation Haloperidol 5.4411575062
MESH:D011618 Psychotic Disorders Clozapine 9.9915331141
MESH:D011618 Psychotic Disorders Haloperidol 9.9911575062
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012559 Schizophrenia Clozapine 4.2320580759 11151749 20107430 16141801 20521326 18806925 18855531 20521320 17726453 20452607 17667964 17123785 11763009 20168265 19369910
MESH:D012559 Schizophrenia Haloperidol 4.231830565 19369910 18513383 20107430
MESH:D017180 Tachycardia, Ventricular Haloperidol 5.1520210726
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.157505956 6582329 6587162 3712494 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D015430 Weight Gain Clozapine 4.7920521320 20107430 20564506 16402076 16141801 17502770
MESH:D015431 Weight Loss Clozapine 5.6217933447
Pathway ID Pathway Name
KEGG:03040 Spliceosome
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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