AutismKB 2.0

Annotation Detail for HEATR1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HEATR1 ( BAP28,FLJ10359,MGC72083 )
Gene Full Name: HEAT repeat containing 1
Band: 1q43
Quick LinksEntrez ID:55127; OMIM: NA; Uniprot ID:HEAT1_HUMAN; ENSEMBL ID: ENSG00000119285; HGNC ID: 25517
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HEATR1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HEATR1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of HEATR1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HEATR1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HEATR1 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of HEATR1 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of HEATR1 mRNAincreases expression 20106945
D018038 Sodium Selenite Sodium Selenite results in increased expression of HEATR1 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.287525203
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.8514694615
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.086135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.0820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.0812371664
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3715095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.7021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.7021346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.7019164858 15968718 10663392 18071297 12594235 12958197 12392966 10915739 11739529 16109766 11743745 11421492 16485898 17522070 19420014 19085960 12153990 19416960 17562736 17906064 18713872 11834606 16393943 16177239 19370779 14725611 2444490 16781746 19923254 10774834 15619225 16227642 11287661 16081117 12540782 12705907 11529661 11461765 14550746 14986274 19739265
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.7015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005234 Fatty Liver Cyclosporine 3.1019224547
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.228314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.5712371664
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 12969438 12587719 19784758 16610002 19014921 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.227678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.682876784 2876786 6135515
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.5316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.5316049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.5314694615
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3518760546
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.798532709
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142671697
    • No data
    No data
    Releated drug ID Related drug Name
    PA450626nicotine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved