AutismKB 2.0

Annotation Detail for TMEM38B


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Basic Information Top
Gene Symbol:TMEM38B ( C9orf87,D4Ertd89e,FLJ10493,TRIC-B,TRICB,bA219P18.1 )
Gene Full Name: transmembrane protein 38B
Band: 9q31.2
Quick LinksEntrez ID:55151; OMIM: 611236; Uniprot ID:TM38B_HUMAN; ENSEMBL ID: ENSG00000095209; HGNC ID: 25535
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
protein quantitative trait loci
menarche (age at onset)
REPRODUCTION
Desease Name
Protein quantitative trait loci
Menarche (age at onset)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TMEM38B mRNAincreases expression 19933214
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TMEM38B mRNAincreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of TMEM38B mRNAincreases expression 16474171
D004958 Estradiol Estradiol results in increased expression of TMEM38B mRNAincreases expression 16474171
D019833 Genistein Genistein results in increased expression of TMEM38B mRNAincreases expression 16474171
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of TMEM38B mRNAincreases expression 16474171
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TMEM38B mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D000230 Adenocarcinoma Estradiol 4.6611473722
MESH:D000230 Adenocarcinoma Genistein 4.6611473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9817123778
MESH:D001943 Breast Neoplasms Estradiol 1.9816675129 19861407 12948864 18497071 14630087 17261762 17289903 17018787
MESH:D001943 Breast Neoplasms Genistein 1.9817200150 16873071 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.2116924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.2116924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.4816332659
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003704 Dementia Polychlorinated Biphenyls 4.9816140633
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.5116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 18230668 16714409
MESH:D004714 Endometrial Hyperplasia Genistein 4.9916402032
MESH:D016889 Endometrial Neoplasms Estradiol 8.0819148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 8.0811473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005909 Glioblastoma Genistein 3.4316598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916354765 18606429 16959395 15340226 8697196
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 8.0116393666
MESH:D007333 Insulin Resistance Estradiol 8.0116393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D007938 Leukemia Genistein 3.1417468513 18980019
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.6217823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6212878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8016984957
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 6.661423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.6612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6516891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.6512929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D009203 Myocardial Infarction Genistein 2.9517141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.2316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.2317141266
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations bisphenol A 26.3911399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 26.3916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 26.3916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 26.3914600291
MESH:D010024 Osteoporosis Genistein 3.4119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3916169203
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010051 Ovarian Neoplasms Genistein 5.1419005980
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4716702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.8610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.8611118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.5120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.5120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1016740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.1016740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1015256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.1015721890
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816045194 16684133
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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