AutismKB 2.0

Annotation Detail for ARHGEF10L


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Basic Information Top
Gene Symbol:ARHGEF10L ( FLJ10521,GrinchGEF,KIAA1626 )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 10-like
Band: 1p36.13
Quick LinksEntrez ID:55160; OMIM: 612494; Uniprot ID:ARGAL_HUMAN; ENSEMBL ID: ENSG00000074964; HGNC ID: 25540
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200050Regulation of RhoA activity
No data
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Related Diseases/Disorders Top
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Desease Name
CANCER
Basal cell carcinoma (cutaneous)
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ARHGEF10L mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of ARHGEF10L mRNAincreases expression 19774075
D016572 Cyclosporine Cyclosporine results in decreased expression of ARHGEF10L mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of ARHGEF10L mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of ARHGEF10L mRNAincreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1518218290 18057881 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 4.3715238619
MESH:D001281 Atrial Fibrillation Amiodarone 4.1618651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.2719483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9915710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.6218974383
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1511421492 14550746 17522070 11529661 16177239 11739529 16781746 17906064 14725611 11287661 16109766 12540782 12958197 10915739 12705907 11743745 14986274 19739265 16227642 10663392 11834606 12153990 19085960 18713872 16081117 2444490 19416960 19923254 18071297 15619225 11461765 19370779 16485898 12594235 12392966 19164858 10774834 17562736 19420014 15968718 16393943
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.1518218290 15265979
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D050171 Dyslipidemias Dietary Fats 3.7018367378
MESH:D005234 Fatty Liver Amiodarone 15.4214986274
MESH:D005234 Fatty Liver Cyclosporine 15.4219224547
MESH:D005234 Fatty Liver Dietary Fats 15.4218296743 17967931 19551842 19004024
MESH:D005355 Fibrosis Cyclosporine 10.3512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 10.3518296743
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006529 Hepatomegaly Amiodarone 4.2315265979
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006937 Hypercholesterolemia Amiodarone 10.448137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 10.4421332399
MESH:D006949 Hyperlipidemias Dietary Fats 4.0221332399
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007037 Hypothyroidism Amiodarone 5.0017991464 18020914
MESH:D007249 Inflammation Dietary Fats 2.5920412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3211836018 18457598
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.418314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D008064 Lipidoses Amiodarone 3.7615342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0518296743
MESH:D008107 Liver Diseases Acetaminophen 1.6919460945 16611625 19014921 16610002 12969438 19784758 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008133 Long QT Syndrome Amiodarone 3.8515350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 3.6012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0918516814
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009181 Mycoses Amiodarone 5.5117974566 12754197
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity Dietary Fats 2.3518674790 21332399 20132043 19632207 18457598 20518802 16723640 17217161 11836018
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9611597910 12832656 12490602
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.6218724381
MESH:D013276 Stomach Ulcer Amiodarone 3.6818087811
MESH:D013610 Tachycardia Amiodarone 4.7311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.6319225199
MESH:D013959 Thyroid Diseases Amiodarone 5.3719731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.3418020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.7311989578 17467628
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D015430 Weight Gain Dietary Fats 4.0616723640
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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