AutismKB 2.0

Annotation Detail for CENPQ


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Basic Information Top
Gene Symbol:CENPQ ( C6orf139,CENP-Q,FLJ10545 )
Gene Full Name: centromere protein Q
Band: 6p12.3
Quick LinksEntrez ID:55166; OMIM: 611506; Uniprot ID:CENPQ_HUMAN; ENSEMBL ID: ENSG00000031691; HGNC ID: 21347
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Chromosome Maintenance
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CENPQ proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of CENPQ mRNAdecreases expression 20106945
D005472 Fluorouracil CENPQ protein affects the susceptibility to Fluorouracilaffects response to substance 15331170
D005472 Fluorouracil Fluorouracil results in increased expression of CENPQ mRNAincreases expression 15331170
C011890 kojic acid kojic acid results in decreased expression of CENPQ mRNAdecreases expression 16595896
D011374 Progesterone Progesterone results in increased expression of CENPQ mRNAincreases expression 18070364
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CENPQ mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 14514962 15322242
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Fluorouracil 9.7117963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.7111748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.8617868700
MESH:D001930 Brain Injuries Progesterone 4.6815845082 15380490 15665606
MESH:D001943 Breast Neoplasms Fluorouracil 1.8916595493 18357371 16557594 16110121 19217205 18608205 15136595
MESH:D001943 Breast Neoplasms Progesterone 1.8915562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 9.0417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.0416835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.2721507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2717088986 16799960 18930000 16332177 17971768 17045692
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5618986760 16757204 16280240 17066447
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115340226 16354765 15668235 8697196 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2716340194 17016597 17172411 17169374 16510598 17287894 15001691 17018589 17725105 18772588
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017594712 20501625 17016601 17401013 15289873 18383874 18448328 17255274 18288408 18509181 18949393 16303861 16282729 16524972 16391804 16331619 17695437 14970324 17094418 15148649 18802399 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.9117187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.1617692515
MESH:D004715 Endometriosis Progesterone 9.9616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.969294722 10568697
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5116481741 16337965 16785472 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Cyclosporine 9.9112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.9120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5918337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16354765 15340226 18606429 16959395
MESH:D006973 Hypertension Cyclosporine 5.2810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2818670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8215869954
MESH:D007249 Inflammation Progesterone 5.4615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.508314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3012371664
MESH:D007680 Kidney Neoplasms Fluorouracil 8.3016985049
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.032125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Fluorouracil 8.0317045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.998603461
MESH:D008114 Liver Neoplasms, Experimental kojic acid 10.9918544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.9912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5714755239
MESH:D008175 Lung Neoplasms Fluorouracil 3.5715246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0511408345 17203775
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8716757204 18986760
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms Fluorouracil 2.7418239605 18600527 16928823
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D010051 Ovarian Neoplasms Progesterone 2.6016525653 17393432
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7516929163 19003803 15113037 16500647
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3619082440 18626508
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3018286688 18722050 16160472 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9418045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.7415862959 16503802
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 17172411 16424979 15786421 18396642 19084572 18567086 19015929 16951190 17498489
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:22172 Chromosome Maintenance
REACT:383 DNA Replication
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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