AutismKB 2.0

Annotation Detail for FAIM


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Basic Information Top
Gene Symbol:FAIM ( FAIM1 )
Gene Full Name: Fas apoptotic inhibitory molecule
Band: 3q22.3
Quick LinksEntrez ID:55179; OMIM: NA; Uniprot ID:FAIM1_HUMAN; ENSEMBL ID: ENSG00000158234; HGNC ID: 18703
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200128Neurotrophic factor-mediated Trk receptor signaling
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FAIM mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of FAIM mRNAincreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FAIM mRNAincreases expression 20504355
D003042 Cocaine Cocaine affects the expression of FAIM mRNAaffects expression 15681117
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNAaffects cotreatment|decreases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNAaffects cotreatment|decreases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of FAIM mRNAaffects cotreatment|decreases expression 16931933
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of FAIM mRNAaffects cotreatment|increases expression 17404688
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNAaffects cotreatment|decreases expression 16931933
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FAIM mRNAaffects binding|decreases expression|increases activity 19710929
C025299 polyphenols polyphenols results in decreased expression of FAIM mRNAdecreases expression 16293270
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of FAIM mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of FAIM mRNAincreases expression 17404688
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNAaffects cotreatment|decreases expression 16931933
C017947 sodium arsenite sodium arsenite results in decreased expression of FAIM mRNAdecreases expression 16014739
D014635 Valproic Acid Valproic Acid results in decreased expression of FAIM mRNAdecreases expression 19101580
D014810 Vitamin E Vitamin E results in increased expression of FAIM mRNAincreases expression 19244175
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of FAIM mRNAaffects cotreatment|decreases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.548875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.879612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3020127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.653712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.656695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5316434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9616712894 17306315
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001321 Autistic Disorder Valproic Acid 2.0018396377 18316065 17157402 15238991 17688650 17507914 19460635 18985861 19232924 18558336 18940202 20603192 18775368 16609825 18177632
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.081440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0917594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1719483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.428888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4017868700
MESH:D001930 Brain Injuries Progesterone 4.3015845082 15380490 15665606
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8917474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.8918497071 12948864 16675129 17289903 17018787 14630087 19861407 17261762
MESH:D001943 Breast Neoplasms Progesterone 1.8915562024 17614352 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9716050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.613581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6116924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.6115276417 17306315 16507464
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6220419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6218572023
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.196135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.197505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.1918566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.1919524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.9119486331 9022650
MESH:D002779 Cholestasis pirinixic acid 7.9119176532
MESH:D019970 Cocaine-Related Disorders Cocaine 5.7719606084
MESH:D003110 Colonic Neoplasms polyphenols 2.6816293270
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.728888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7219769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0618551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.848970840 12868966 11906362 18759878 14531868 2524372 11298694 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.522952479 3621924
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5317187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.1018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.109022650 9328219 9653073 1440618 8291058 18289764 6679447 18692083 11289319 6482804 16192314 18648102 7440962
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.1019370779
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.1019641884 1733752
MESH:D004362 Drug Toxicity Lamivudine 8.8615040536
MESH:D004362 Drug Toxicity Zidovudine 8.8615040536
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:C538011 Eales disease Vitamin E 4.779068938
MESH:D004487 Edema pirinixic acid 2.5112083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8217692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0011473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 3.7916134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.193659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9518234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.616426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.383581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3816530937
MESH:D005234 Fatty Liver pirinixic acid 13.3820131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 13.3814986274 19224547
MESH:D005234 Fatty Liver Zidovudine 13.3818299183
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.178888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7316452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7420471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7416080930
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006402 Hematologic Diseases Zidovudine 4.7412579204
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.556705139
MESH:D006509 Hepatitis B Lamivudine 5.1317703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.1315274664 15631357 15309715 16476009 12044531
MESH:D006529 Hepatomegaly pirinixic acid 3.0419176532 16221962 18467677 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7116863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D015658 HIV Infections Indinavir 15.6411363243 15388451 11141242
MESH:D015658 HIV Infections Lamivudine 15.6417530837 11141242 20032539 9296927
MESH:D015658 HIV Infections Saquinavir 15.6411141242 15388451
MESH:D015658 HIV Infections Zidovudine 15.6411698656 17358032 11363243 20032539 11141242
MESH:D006689 Hodgkin Disease sodium arsenite 3.1812676792
MESH:D019584 Hot Flashes Estradiol 10.2617088409
MESH:D019584 Hot Flashes Vitamin E 10.2614716179
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4415869954
MESH:D007248 Infertility, Male sodium arsenite 3.0115346721 12646999
MESH:D007249 Inflammation polyphenols 5.4716366677
MESH:D007249 Inflammation Progesterone 5.4715869954
MESH:D007251 Influenza, Human Vitamin E 4.2816624496
MESH:D007333 Insulin Resistance Estradiol 7.2616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.2616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.088074119 9022650
MESH:D007674 Kidney Diseases Estradiol 10.2115618244
MESH:D007674 Kidney Diseases sodium arsenite 10.2120008137
MESH:D007674 Kidney Diseases Vitamin E 10.2112488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.0016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.006582329
MESH:D007680 Kidney Neoplasms Estradiol 18.0015610895
MESH:D007680 Kidney Neoplasms Zidovudine 18.0012579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.4420370541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1516294345 17596541
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.219327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4815474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4816169303
MESH:D008107 Liver Diseases polyphenols 2.7916698588
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.777678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.7721137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 10.7715890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 10.7716712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.942876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.94598648 3712494 1399818 6587162
MESH:D008171 Lung Diseases sodium arsenite 7.5019095001
MESH:D008171 Lung Diseases Vitamin E 7.5016863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9218569708 18520028 18816296 6695378 17053015 20135361 20464547 20869020 20064080
MESH:D008175 Lung Neoplasms sodium arsenite 4.9216712894 19931552 15276417 17077188 17306315
MESH:D008175 Lung Neoplasms Vitamin E 4.9211062179
MESH:D008175 Lung Neoplasms Zidovudine 4.9218800350
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1217203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.1211408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008545 Melanoma sodium arsenite 2.0316487513 19082730
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.9017358032
MESH:D008881 Migraine Disorders Valproic Acid 3.2118803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009164 Mycobacterium Infections Indinavir 5.4721442799
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1717596541
MESH:D009203 Myocardial Infarction Cocaine 6.1318072171
MESH:D009203 Myocardial Infarction pirinixic acid 6.1319151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3216411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.917678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.483581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.2811141357
MESH:D009369 Neoplasms pirinixic acid 8.2817405874
MESH:D009369 Neoplasms sodium arsenite 8.2811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7120056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Estradiol 3.6911399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.246679447
MESH:D009436 Neural Tube Defects sodium arsenite 12.2412854658
MESH:D009436 Neural Tube Defects Valproic Acid 12.248888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9716049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.974026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010051 Ovarian Neoplasms Estradiol 7.9519401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.9516525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.9517306315 15276417
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.8820603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0517292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0516740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0516039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0515084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.6011422049 12752131
MESH:D011618 Psychotic Disorders Cocaine 4.8416134406
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
MESH:D012206 Rhabdomyolysis Lamivudine 5.599296927
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 10.1318551238
MESH:D012640 Seizures Cocaine 10.1310454489
MESH:D012640 Seizures Valproic Acid 10.1314763951 15475178 16876388 11738929 1511512 17978042 11044598 3137016
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7519755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 5.7518572023 19524636
MESH:D013119 Spinal Cord Injuries Progesterone 4.3316503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 9.6112854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.6119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.602093021 20155912
MESH:D013274 Stomach Neoplasms Zidovudine 2.6017696246
MESH:D020521 Stroke Vitamin E 3.5416517955
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.3117997062
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.906582329 1399818 3712494 6587162 7505956
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.0016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.008074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.0017053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.0011723127 16452187 16712894 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3710091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7911813266
MESH:D014625 Vaginal Neoplasms Zidovudine 4.8012579204
MESH:D014652 Vascular Diseases sodium arsenite 4.4717056641
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38647
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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