AutismKB 2.0

Annotation Detail for PPP2R1A


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Basic Information Top
Gene Symbol:PPP2R1A ( MGC786,PP2A-Aalpha,PP2AAALPHA,PR65A )
Gene Full Name: protein phosphatase 2, regulatory subunit A, alpha
Band: 19q13.41
Quick LinksEntrez ID:5518; OMIM: 605983; Uniprot ID:2AAA_HUMAN; ENSEMBL ID: ENSG00000105568; HGNC ID: 9302
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa05142Chagas disease
hsa04310Wnt signaling pathway
hsa04730Long-term depression
hsa04530Tight junction
hsa04350TGF-beta signaling pathway
hsa04114Oocyte meiosis
Pathway IDPathway Name
Metabolism of carbohydrates
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Signalling by NGF
Hemostasis
Opioid Signalling
Signaling in Immune system
Integration of energy metabolism
Pathway IDPathway Name
200087PLK1 signaling events
200113ErbB1 downstream signaling
Pathway IDPathway Name
P00021FGF signaling pathway
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PPP2R1A mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PPP2R1A mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PPP2R1A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PPP2R1A mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of PPP2R1A mRNAaffects expression 18414638
D001554 Benzene Benzene results in increased expression of PPP2R1A mRNAincreases expression 15878777
C095105 bexarotene bexarotene results in increased expression of PPP2R1A mRNAincreases expression 16648578
D003024 Clozapine Clozapine results in increased expression of PPP2R1A mRNAincreases expression 15860345
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PPP2R1A mRNAincreases expression 17942748
D006220 Haloperidol Haloperidol results in increased expression of PPP2R1A mRNAincreases expression 15860345
C027869 lingzhi lingzhi results in decreased expression of PPP2R1A proteindecreases expression 18422750
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of PPP2R1A mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of PPP2R1A mRNAincreases expression 19244175
C025462 sulindac sulfide sulindac sulfide results in decreased expression of PPP2R1A mRNAdecreases expression 12734198
D014315 Triterpenes Triterpenes results in decreased expression of PPP2R1A proteindecreases expression 18422750
C025643 vinclozolin vinclozolin affects the expression of PPP2R1A mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of PPP2R1A mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of PPP2R1A mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 3.977525203
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D018246 Adrenocortical Adenoma Arsenic 5.2417306315
MESH:D000380 Agranulocytosis Clozapine 5.0716160616 12649775 14617031
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0918759972
MESH:D000741 Anemia, Aplastic Benzene 4.3717661222 14761424 11369114
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6419015723
MESH:D020261 Arsenic Poisoning Arsenic 2.8718414634 16835338 12569548 16251483
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D050197 Atherosclerosis Arsenic 3.2512928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 2.1218445737
MESH:D001321 Autistic Disorder Haloperidol 2.1219368416 18080171
MESH:D001855 Bone Marrow Diseases Benzene 5.2616183116
MESH:D001943 Breast Neoplasms Benzene 2.6917162533 11921183
MESH:D001943 Breast Neoplasms bexarotene 2.6916344269 16818667
MESH:D002252 Carbon Tetrachloride Poisoning lingzhi 10.7315673190
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.7316050911
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5917687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.5816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.583084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.5816507464 17306315
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 6.0316247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 6.0312391285
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.6917687452 15504454 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0818640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.4515738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.3118022660 16973168
MESH:D002375 Catalepsy Haloperidol 4.9315215559 1977408
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.4314694615
MESH:D002386 Cataract Acetaminophen 7.4310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.776135515
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8815861022 16919318 17333356 16105132 11677210 17681005 17110522
MESH:D003072 Cognition Disorders Clozapine 4.9817123785
MESH:D003092 Colitis Selenium 3.7917936198
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.1615095906
MESH:D019465 Craniofacial Abnormalities Benzene 2.9215643154
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.9219769572
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0318551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.8520210726
MESH:D003704 Dementia Haloperidol 4.5811575062
MESH:D003872 Dermatitis Benzene 4.7815902427
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9716402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5815331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.0118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.0121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0116485898 11461765 12153990 10915739 19164858 15968718 12392966 19085960 12540782 14725611 19420014 11739529 12594235 12958197 17562736 14986274 14550746 16109766 11529661 17906064 2444490 18713872 10774834 12705907 19923254 18071297 11421492 16227642 17522070 16081117 19370779 16781746 15619225 11743745 16393943 11834606 10663392 19416960 16177239 19739265 11287661
MESH:D056486 Drug-Induced Liver Injury Selenium 9.0115131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D050171 Dyslipidemias Clozapine 4.1916402076
MESH:C538011 Eales disease Vitamin E 4.739068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.8215345470
MESH:D005534 Foot Diseases Arsenic 5.596392382
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9916080930
MESH:D006333 Heart Failure Selenium 3.0717162251
MESH:D006402 Hematologic Diseases Benzene 4.6616183116
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7016490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.0014716179
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4617050553
MESH:D006948 Hyperkinesis Clozapine 4.9316046005
MESH:D006973 Hypertension Arsenic 5.679931084 16076760 11953799
MESH:D006973 Hypertension Benzene 5.6717940673
MESH:D006987 Hypesthesia Arsenic 5.5916093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6717937319
MESH:D007248 Infertility, Male vinclozolin 6.6716467254
MESH:D007251 Influenza, Human Selenium 11.0616624496
MESH:D007251 Influenza, Human Vitamin E 11.0616624496
MESH:D007642 Keratosis Arsenic 5.0116930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 5.9712587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 5.9712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8916518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9816705839
MESH:D007938 Leukemia Benzene 3.3918335105 15935818 14694614 17119257
MESH:D007951 Leukemia, Myeloid Benzene 4.3217506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7019478238
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5517339181
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D008064 Lipidoses Clozapine 3.9617567588
MESH:D008106 Liver Cirrhosis, Experimental lingzhi 3.2815673190
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.2816169303
MESH:D008107 Liver Diseases Acetaminophen 4.0712969438 16611625 16610002 19460945 19014921 19784758 11587558 12587719
MESH:D008107 Liver Diseases Arsenic 4.0711134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.737678174
MESH:D008113 Liver Neoplasms Arsenic 4.7316368122
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.176135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Benzene 6.1712562636
MESH:D008171 Lung Diseases Vitamin E 3.1816863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.8414698565
MESH:D008175 Lung Neoplasms Arsenic 4.9617976673 19168569 17306315
MESH:D008175 Lung Neoplasms Benzene 4.9612562636
MESH:D008175 Lung Neoplasms bexarotene 4.9617849452
MESH:D008175 Lung Neoplasms Vitamin E 4.9611062179
MESH:D008223 Lymphoma Benzene 3.7417584886 17119257
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.1611161223
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.4612562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 10.1811921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 10.1815591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.1815318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D001523 Mental Disorders Clozapine 8.4316856516
MESH:D001523 Mental Disorders Haloperidol 8.4316856516
MESH:D008654 Mesothelioma Selenium 2.7915107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.4119142101
MESH:D009101 Multiple Myeloma Benzene 3.6617119195
MESH:D017202 Myocardial Ischemia Arsenic 3.9815371236
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.887678174 18551238
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.8119196722
MESH:D009436 Neural Tube Defects Arsenic 7.6616620997
MESH:D009436 Neural Tube Defects Benzene 7.6615643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.3817056641
MESH:D009765 Obesity Clozapine 3.0218515891 19142110
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.2916049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.2914694615
MESH:D009784 Occupational Diseases Benzene 15.2917119257 15727169 15612468 17479406 15913788 16737584 15935809 17178637 15576619
MESH:D010051 Ovarian Neoplasms Arsenic 5.2317306315
MESH:D010051 Ovarian Neoplasms Benzene 5.2312562636
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.0116905509 6392382 15371236
MESH:D010954 Plasmacytoma Selenium 4.9215087411
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9218042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D011471 Prostatic Neoplasms Arsenic 3.4316140617
MESH:D011471 Prostatic Neoplasms Vitamin E 3.4315084515
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D011507 Proteinuria Arsenic 4.0121343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.3315861022 16919318
MESH:D011595 Psychomotor Agitation Haloperidol 4.9711575062
MESH:D011618 Psychotic Disorders Clozapine 9.1615331141
MESH:D011618 Psychotic Disorders Haloperidol 9.1611575062
MESH:D012559 Schizophrenia Clozapine 4.1020521326 20452607 17123785 18855531 11151749 17726453 19369910 17667964 16141801 20168265 20521320 11763009 18806925 20580759 20107430
MESH:D012559 Schizophrenia Haloperidol 4.1019369910 1830565 20107430 18513383
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5418551238
MESH:D012871 Skin Diseases Arsenic 5.0417938729 16759981 17548696 6392382 17050553 16702368 19834688 17453740 15952646 16353154 18709164
MESH:D012871 Skin Diseases Vitamin E 5.0418709164
MESH:D012878 Skin Neoplasms Arsenic 3.0117976673 17050553 17029826 19538983 15504454 16251483
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013276 Stomach Ulcer lingzhi 5.0112467913
MESH:D020521 Stroke Vitamin E 3.5216517955
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.7220210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013953 Thymus Neoplasms Benzene 4.9810850423
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.2117976673 18640142 19322015 19429237 11144890 17306315 15987713
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3410091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014594 Uterine Neoplasms Benzene 16.2412562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 16.2414692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 16.2418645019
MESH:D014652 Vascular Diseases Arsenic 4.7517056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D015430 Weight Gain Clozapine 4.4720521320 16141801 16402076 20107430 20564506 17502770
MESH:D015431 Weight Loss Clozapine 5.1017933447
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
KEGG:05142 Chagas disease (American trypanosomiasis)
REACT:383 DNA Replication
REACT:604 Hemostasis
KEGG:05160 Hepatitis C
REACT:1505 Integration of energy metabolism
KEGG:04730 Long-term depression
REACT:33953 Metabolism of carbohydrates
REACT:474 Metabolism of carbohydrates
KEGG:03015 mRNA surveillance pathway
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
REACT:11045 Signaling by Wnt
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:04350 TGF-beta signaling pathway
KEGG:04530 Tight junction
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02506 - 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
DB06905 - (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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