AutismKB 2.0

Annotation Detail for PPP2R1B


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Basic Information Top
Gene Symbol:PPP2R1B ( MGC26454,PP2A-Abeta,PR65B )
Gene Full Name: protein phosphatase 2, regulatory subunit A, beta
Band: 11q23.1
Quick LinksEntrez ID:5519; OMIM: 603113; Uniprot ID:2AAB_HUMAN; ENSEMBL ID: ENSG00000137713; HGNC ID: 9303
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa05142Chagas disease
hsa04310Wnt signaling pathway
hsa04730Long-term depression
hsa04530Tight junction
hsa04350TGF-beta signaling pathway
hsa04114Oocyte meiosis
Pathway IDPathway Name
Metabolism of carbohydrates
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Signalling by NGF
Hemostasis
Opioid Signalling
Signaling in Immune system
Integration of energy metabolism
No data
Pathway IDPathway Name
P00021FGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004041 Dietary Fats Dietary Fats results in decreased expression of PPP2R1B mRNAdecreases expression 18042831
18503570
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PPP2R1B mRNAaffects cotreatment|increases expression 17183730
C029938 nickel sulfate nickel sulfate results in increased expression of PPP2R1B mRNAincreases expression 16780908
C041786 palm oil palm oil results in decreased expression of PPP2R1B mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of PPP2R1B mRNAincreases expression 18301758
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PPP2R1B mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in decreased expression of PPP2R1B mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D055371 Acute Lung Injury nickel sulfate 10.1711954676 16100012 19131640 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 10.1718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001161 Arteriosclerosis Dietary Fats 4.2515238619
MESH:D001321 Autistic Disorder Valproic Acid 1.9915238991 18558336 19232924 17507914 18775368 18316065 16609825 17688650 18396377 18985861 19460635 20603192 18177632 17157402 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.788888407 16575769 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7819769572
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 4.0216780908 11298694 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2319641884 1733752
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.513659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.363922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D005234 Fatty Liver Dietary Fats 14.8217967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 14.8219236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 14.8219224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4618558336 8888407
MESH:D005355 Fibrosis Dietary Fats 3.8818296743
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1216080930
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3519176532 16221962 18467677 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9816612254
MESH:D007249 Inflammation Dietary Fats 2.5520412841
MESH:D007251 Influenza, Human Vitamin E 4.6616624496
MESH:D007333 Insulin Resistance Dietary Fats 7.8218457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.8216306350
MESH:D007674 Kidney Diseases Vitamin E 2.9512488133
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0118296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4516169303
MESH:D008113 Liver Neoplasms pirinixic acid 1.9020007298 16377806 15890375
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms marker/mechanism
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008881 Migraine Disorders Valproic Acid 3.3818765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.308888407 16359493
MESH:D009765 Obesity Dietary Fats 4.6220518802 17217161 19632207 18457598 21332399 16723640 18674790 11836018 20132043
MESH:D009765 Obesity pirinixic acid 4.6220558911
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.9811422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9115475178 16876388 3137016 17978042 11044598 14763951 1511512 11738929
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
KEGG:05142 Chagas disease (American trypanosomiasis)
REACT:383 DNA Replication
REACT:604 Hemostasis
KEGG:05160 Hepatitis C
REACT:1505 Integration of energy metabolism
KEGG:04730 Long-term depression
REACT:474 Metabolism of carbohydrates
REACT:33953 Metabolism of carbohydrates
KEGG:03015 mRNA surveillance pathway
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
REACT:11045 Signaling by Wnt
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:04350 TGF-beta signaling pathway
KEGG:04530 Tight junction
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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