AutismKB 2.0

Annotation Detail for C12orf35


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Basic Information Top
Gene Symbol:C12orf35 ( FLJ10652,FLJ20696 )
Gene Full Name: chromosome 12 open reading frame 35
Band: 12p11.21
Quick LinksEntrez ID:55196; OMIM: NA; Uniprot ID:CL035_HUMAN; ENSEMBL ID: ENSG00000174718; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D007213 Indomethacin Indomethacin results in decreased expression of C12ORF35 mRNAdecreases expression 16984733
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of C12ORF35 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.7314514962 15322242 11752688
MESH:D000230 Adenocarcinoma Indomethacin 2.8716537180
MESH:D000236 Adenoma Indomethacin 3.7011497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.2616835633
MESH:D016301 Alveolar Bone Loss Indomethacin 6.4417225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7817627676 15579461
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.4511748828
MESH:D001014 Aortic Aneurysm Indomethacin 5.5210231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.6410388637
MESH:D018771 Arthralgia Indomethacin 6.242160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.9011248219
MESH:D001477 Bartter Syndrome Indomethacin 5.7510684365
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.8615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0515746008
MESH:D001929 Brain Edema Indomethacin 6.0911481608
MESH:D002545 Brain Ischemia Indomethacin 5.3012524144
MESH:D001943 Breast Neoplasms Indomethacin 2.1517401462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1520435547
MESH:D002056 Burns Indomethacin 5.4710459503
MESH:D002100 Cachexia Indomethacin 5.8915141370 11239499 15625704 16537180
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 2.4816391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.6111053908
MESH:D018276 Carcinoma, Medullary Indomethacin 6.2418791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.5617341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.9512636206 15482327
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.6018670907 16120746 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.6316835633
MESH:D002764 Cholecystitis Indomethacin 6.2411181007
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.268697196 12621046 15668235 16354765 15340226
MESH:D003110 Colonic Neoplasms Indomethacin 2.6515963497 15786552 11260862 15625704 15637740 15936596
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3617054584 12606626 18059344 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.5317141729 14669216
MESH:D018352 Coronavirus Infections Indomethacin 6.7917302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 20055451 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7517107852
MESH:D003967 Diarrhea Indomethacin 4.467907874 7237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.1211462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 6.0418446180 18043480 16326151 12774134 17190690 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 4.8117351913 11595431 11991626 16699067 11595415 10671773 11535926 17045617 17151854 17202747 17329845
MESH:D004487 Edema Indomethacin 8.7919703484 7907874 8273558 16100529 10653021 8985016 7990266
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.7912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.9716714409 18230668 15322242
MESH:D004715 Endometriosis Indomethacin 10.8015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.8010568697 9294722
MESH:D019446 Endotoxemia Indomethacin 5.3918509659
MESH:D004751 Enteritis Indomethacin 5.8110567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.7517980183
MESH:D004802 Eosinophilia Indomethacin 4.8111298111
MESH:D004938 Esophageal Neoplasms Indomethacin 2.8911005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3811564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.2211858732
MESH:D005334 Fever Indomethacin 4.6217627676 11852909 10431976
MESH:D005354 Fibrosarcoma Indomethacin 5.7810962813
MESH:D005355 Fibrosis Indomethacin 11.5117994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.5120067830
MESH:D005499 Folliculitis Indomethacin 6.2411298111
MESH:D005756 Gastritis Indomethacin 5.8115046732
MESH:D005909 Glioblastoma Indomethacin 3.8612870263
MESH:D005910 Glioma Indomethacin 3.3716487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.6911849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.6610696789
MESH:D006073 Gout Indomethacin 6.2411248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 4.0515482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5511294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8911000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 5.1215633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 5.3615135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.6515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 5.1218606429 15340226 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Indomethacin 4.1812727271
MESH:D034321 Hyperamylasemia Indomethacin 6.7917883296
MESH:D006940 Hyperemia Indomethacin 5.8912524144
MESH:D006949 Hyperlipidemias Indomethacin 4.7717546600
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0418850075 18670907
MESH:D007077 Ileal Diseases Indomethacin 6.0918306037 10574470
MESH:D007079 Ileitis Indomethacin 6.2410651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 6.4416133044
MESH:D007249 Inflammation Indomethacin 5.853291741 12568917 7812673
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.8512200463 12878042
MESH:D007410 Intestinal Diseases Indomethacin 5.0915610444 11686837 17329856 11855677 11713966 15831440 10210152 18236018 17994277
MESH:D019586 Intracranial Hypertension Indomethacin 6.4415241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8916580747
MESH:D007579 Jejunal Diseases Indomethacin 6.0910574470 16133968 18306037
MESH:D007674 Kidney Diseases Indomethacin 3.5117190690
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.3412228301 10320625 11703811
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.2910785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6918360721
MESH:D007964 Leukocytosis Indomethacin 6.4416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.7917980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.7911479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.6218194892
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.6212878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3812151625
MESH:D008175 Lung Neoplasms Indomethacin 2.5811053908 11497255 16537180
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5811884234 19555203
MESH:D008881 Migraine Disorders Indomethacin 4.0111903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.3712636206
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.4312213967
MESH:D009362 Neoplasm Metastasis Indomethacin 3.3211053908 11239499 16537180
MESH:D009374 Neoplasms, Experimental Indomethacin 4.9015625704 10663608
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8914600291
MESH:D019636 Neurodegenerative Diseases Indomethacin 4.3812349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 6.246374098
MESH:D010003 Osteoarthritis Indomethacin 3.937009135
MESH:D010146 Pain Indomethacin 3.8917627676 3291741 17440234 13679232
MESH:D010149 Pain, Postoperative Indomethacin 5.7512538197 18702446
MESH:D010195 Pancreatitis Indomethacin 4.5217883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.7916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.6212349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.7911903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.3212520081
MESH:D010437 Peptic Ulcer Indomethacin 6.0411148446
MESH:D010518 Periodontitis Indomethacin 5.9817225004
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.2318163543
MESH:D047928 Premature Birth Indomethacin 5.8917000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 4.0811118676 11222880 11896295 11399792
MESH:D011507 Proteinuria Indomethacin 4.7711849393
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.5118990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2316192470
MESH:D013272 Stomach Diseases Indomethacin 5.3016280098 10486359 17638125 18209964 10192188 17160473 18545984 10215738 16184426 16113693 15472012 17207306 15038085
MESH:D013274 Stomach Neoplasms Indomethacin 2.3615609394
MESH:D013276 Stomach Ulcer Indomethacin 4.1316631530 12500499 10878458 14567935 18431645 18237397 17627676 12787963 15104355 11145282 16150113 12467913 11906479 18087811 10750652 16252198 12077510 18193104 10423059 18543354 17895592 15255614 15138204 12498302 16397915 11595415 17977527 17657623 16755016 11523592 17654042 18299717 18181030 16169175 17918041 17135157 11595431 11729361 1323529 18726076 16934674 18209962
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.9712697716
MESH:D013964 Thyroid Neoplasms Indomethacin 3.9611352223 18791128 14736730
MESH:D014456 Ulcer Indomethacin 5.7810574470 17380554
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.6612125929
MESH:D014839 Vomiting Indomethacin 5.8111897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.3215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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