AutismKB 2.0

Annotation Detail for RPRD1A


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Basic Information Top
Gene Symbol:RPRD1A ( FLJ10656,HsT3101,MGC19513,P15RS )
Gene Full Name: regulation of nuclear pre-mRNA domain containing 1A
Band: 18q12.2
Quick LinksEntrez ID:55197; OMIM: 610347; Uniprot ID:RPR1A_HUMAN; ENSEMBL ID: ENSG00000141425; HGNC ID: 25560
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of RPRD1A mRNAincreases expression 16788091
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of RPRD1A geneincreases mutagenesis 16495775
D014212 Tretinoin Tretinoin results in increased expression of RPRD1A mRNAincreases expression 16788091
D014635 Valproic Acid Valproic Acid results in decreased expression of RPRD1A mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3519490988
MESH:D000236 Adenoma Ethylnitrosourea 3.926695378
MESH:D000505 Alopecia Tretinoin 3.9415955085
MESH:D000550 Amblyopia Valproic Acid 5.9617688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.9017497229
MESH:D001169 Arthritis, Experimental Tretinoin 3.3016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Valproic Acid 1.9818775368 18985861 18396377 19232924 18316065 18558336 17688650 20603192 17507914 15238991 18177632 19460635 17157402 18940202 16609825
MESH:D001471 Barrett Esophagus Tretinoin 4.9116935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.2420046352 17594078
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0316197459 16206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.638888407
MESH:D001927 Brain Diseases Ethylnitrosourea 5.2814991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.6816651633 16436596 15144691 16357521 18412241
MESH:D001943 Breast Neoplasms Tretinoin 2.2316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.2216813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.8816168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.921917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716096774 16051514
MESH:D002386 Cataract Tretinoin 3.3017460283
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.9816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.7117160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.2216129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8220734317
MESH:D002822 Choriocarcinoma Tretinoin 5.8816461808
MESH:D002972 Cleft Palate Tretinoin 2.809407595
MESH:D003092 Colitis Tretinoin 4.2617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.779664655 10589399 8800419 9142499 14991402 9224671 9125849 16925845 9211117 17551590
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.778888407 17688650 16575769
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2519641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.511851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.7118357618
MESH:D004489 Edema, Cardiac Tretinoin 5.1918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3516569247
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.713659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.6416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.1120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.966426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.693659116
MESH:D005124 Eye Abnormalities Tretinoin 3.8716938888 9664655
MESH:D005234 Fatty Liver Valproic Acid 3.7214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.6116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.648888407 18558336
MESH:D005355 Fibrosis Tretinoin 4.0717994277
MESH:D005909 Glioblastoma Ethylnitrosourea 8.2316436596
MESH:D005909 Glioblastoma Tretinoin 8.2317312396
MESH:D005910 Glioma Ethylnitrosourea 3.6218412241 16357521 16651633
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.8816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0714991402 9664655
MESH:D006849 Hydrocephalus Valproic Acid 5.5017688650
MESH:D006930 Hyperalgesia Tretinoin 3.5316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.1316778211
MESH:D007410 Intestinal Diseases Tretinoin 4.3317994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3317551590 15992940
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.2717379185
MESH:D007938 Leukemia Tretinoin 2.9317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1216482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0719850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3919035177 19029980 9834237 17361223 17107899 16891316 19642359 17294898 17712046 19075265 17301526 12679006 16331271 19225113 17217047 16788101 15748426 17506722 16766008 16823087 16140955 17649720 16935935 17339181 17368321
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.589224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.9817228818
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6316019985 6695378 16271038 17703301
MESH:D008223 Lymphoma Ethylnitrosourea 4.2215790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.6115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.7418041768 10767621 10838139
MESH:D008527 Medulloblastoma Tretinoin 2.9117453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008579 Meningioma Ethylnitrosourea 6.7117943659
MESH:D008591 Meningomyelocele Tretinoin 4.9916940565
MESH:D008881 Migraine Disorders Valproic Acid 3.4718803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.458888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.0717596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 8.0717596541
MESH:D009369 Neoplasms Tretinoin 2.5716946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.9616707424
MESH:D009421 Nervous System Malformations Tretinoin 4.289125849
MESH:D009436 Neural Tube Defects Tretinoin 8.129142499
MESH:D009436 Neural Tube Defects Valproic Acid 8.128888407 16359493
MESH:D009442 Neurilemmoma Ethylnitrosourea 6.0516651423 17160924 16003739
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.7117160924
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4416936753
MESH:D010146 Pain Tretinoin 3.2416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5715976015
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.4620603192
MESH:D011507 Proteinuria Tretinoin 4.0716636307
MESH:D019310 Pseudolymphoma Valproic Acid 5.2612752131 11422049
MESH:D011625 Pterygium Tretinoin 5.4216723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 12.4516283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 12.4519155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9914763951 15475178 1511512 17978042 11044598 11738929 16876388 3137016
MESH:D012878 Skin Neoplasms Tretinoin 2.7616467112
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0919490988
MESH:D013226 Status Epilepticus Valproic Acid 5.2612833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.7915790496
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.1816051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.9617262798
MESH:D014376 Tuberculosis Tretinoin 3.4516040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.153119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.208888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0716129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.3316752155
MESH:D014820 Vitiligo Tretinoin 4.5616761959
MESH:D009396 Wilms Tumor Tretinoin 4.3416287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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