AutismKB 2.0

Annotation Detail for SETD5


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Basic Information Top
Gene Symbol:SETD5 ( DKFZp686J18276,FLJ10707,KIAA1757 )
Gene Full Name: SET domain containing 5
Band: 3p25.3
Quick LinksEntrez ID:55209; OMIM: NA; Uniprot ID:SETD5_HUMAN; ENSEMBL ID: ENSG00000168137; HGNC ID: 25566
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SETD5 mRNAincreases expression 12958071
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SETD5 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SETD5 mRNAdecreases expression 19150397
C099555 CD 437 CD 437 results in increased expression of SETD5 mRNAincreases expression 12958071
D016572 Cyclosporine Cyclosporine results in increased expression of SETD5 mRNAincreases expression 20106945
D005472 Fluorouracil Fluorouracil affects the expression of SETD5 mRNAaffects expression 16584549
C051890 irinotecan irinotecan analog results in decreased expression of SETD5 mRNAdecreases expression 18927307
C006253 pirinixic acid pirinixic acid results in increased expression of SETD5 mRNAincreases expression 18301758
C010327 salinomycin salinomycin results in decreased expression of SETD5 mRNAdecreases expression 19682730
D018038 Sodium Selenite Sodium Selenite results in decreased expression of SETD5 mRNAdecreases expression 18175754
C025643 vinclozolin vinclozolin affects the expression of SETD5 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5120127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.5117638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000740 Anemia Fluorouracil 3.8415504547 17963324 16511603
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0520146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.0519217205 16110121 18357371 18608205 16557594 15136595 16595493
MESH:D001943 Breast Neoplasms salinomycin 2.0519682730
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 3.6817121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1017045692 17971768 16332177 16799960 17088986 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7618986760 16757204 17066447 16280240
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8712371664
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0417169374 16510598 17287894 17725105 17016597 15001691 17018589 18772588 17172411 16340194
MESH:D003110 Colonic Neoplasms irinotecan 4.0417725105 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7614970324 16391804 17594712 18802399 17255274 20501625 15289873 15148649 18949393 17695437 18288408 16524972 18383874 16331619 17401013 16282729 17016601 17094418 17454858 16303861 18509181 18448328
MESH:D015179 Colorectal Neoplasms irinotecan 2.7616391804 18259882 15273666 17159606 18509181 16303861 17454858
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.3115131321
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.4215173087 16481741 16785472 17638652 16337965
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver pirinixic acid 8.0319236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.3212639820 12168785
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4815162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1716221962 19176532 18467677 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007248 Infertility, Male vinclozolin 3.1316467254
MESH:D007333 Insulin Resistance pirinixic acid 7.6016306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6014714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7912371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.7916985049
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6921137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 7.6917045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 7.6915890375 16377806 20007298
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.506695378 18569708 18520028 18816296 17053015 20464547 20869020 20064080 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 2.5015246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 3.8519682730
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8916757204 18986760
MESH:D052016 Mucositis irinotecan 5.2017159606
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009362 Neoplasm Metastasis irinotecan 3.2218259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6011141357
MESH:D009369 Neoplasms Fluorouracil 8.6018239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 8.6017405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009447 Neuroblastoma irinotecan 3.548761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.928761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms CD 437 3.3517474084
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7116929163 15113037 19003803 16500647
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0918042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5517292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5518626508 19082440
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5518760546
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1415538739 18722050 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4310029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.5020155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5018396642 19015929 18567086 15786421 16424979 19084572 16951190 17172411 17498489 17522103
MESH:D013274 Stomach Neoplasms irinotecan 3.5015723263
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5417053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.5416720286
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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