AutismKB 2.0

Annotation Detail for PPP2R2B


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Basic Information Top
Gene Symbol:PPP2R2B ( B55BETA,FLJ95686,MGC24888,PP2AB55BETA,PP2ABBETA,PP2APR55B,PP2APR55BETA,PR2AB55BETA,PR2ABBETA,PR2APR55BETA,PR52B,PR55-BETA,PR55BETA,SCA12 )
Gene Full Name: protein phosphatase 2, regulatory subunit B, beta
Band: 5q32
Quick LinksEntrez ID:5521; OMIM: 604325; Uniprot ID:2ABB_HUMAN; ENSEMBL ID: ENSG00000156475; HGNC ID: 9305
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa05142Chagas disease
hsa04530Tight junction
No data
No data
Pathway IDPathway Name
P00021FGF signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
Neurodegenerative diseases
H00063Spinocerebellar ataxia
No data
Desease Name
CHEMDEPENDENCY
smoking cessation
alcohol dependence
Desease Name
Alcohol dependence
Desease Name
Spinocerebellar ataxia 12
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PPP2R2B mRNAdecreases expression 19933214
C014024 2,4,5,2',4',5'-hexachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of PPP2R2B mRNAaffects cotreatment|decreases expression 16984957
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PPP2R2B mRNAaffects expression 21346803
C029955 2-nitrotoluene 2-nitrotoluene results in increased expression of PPP2R2B mRNAincreases expression 16460773
C023035 3,4,5,3',4'-pentachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of PPP2R2B mRNAaffects cotreatment|decreases expression 16984957
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in decreased expression of PPP2R2B mRNAdecreases expression 17785943
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PPP2R2B mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPP2R2B mRNAdecreases expression 19150397
C099813 bromochloroacetic acid bromochloroacetic acid results in increased expression of PPP2R2B mRNAincreases expression 16460773
D003345 Corticosterone Corticosterone results in decreased expression of PPP2R2B mRNAdecreases expression 15755911
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of PPP2R2B mRNAdecreases expression 17005392
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PPP2R2B mRNAdecreases expression 15834898
17557909
D007657 Ketone Bodies Ketone Bodies results in decreased expression of PPP2R2B mRNAdecreases expression 16807920
D001556 Lindane Lindane results in decreased expression of PPP2R2B mRNAdecreases expression 17785943
D011374 Progesterone Progesterone affects the expression of PPP2R2B mRNAaffects expression 17251523
D011374 Progesterone Progesterone results in decreased expression of PPP2R2B mRNAdecreases expression 17556502
D012402 Rotenone Rotenone affects the localization of PPP2R2B proteinaffects localization 18940801
D019311 Staurosporine Staurosporine affects the localization of PPP2R2B proteinaffects localization 18940801
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PPP2R2B mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PPP2R2B mRNAincreases expression 16922920
D014212 Tretinoin Tretinoin results in increased expression of PPP2R2B mRNAincreases expression 16249480
D014415 Tunicamycin Tunicamycin affects the localization of PPP2R2B proteinaffects localization 18940801
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7614514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7914692618
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 10.2616628245
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.2616835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.2912661182
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3915469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.0216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2617868700
MESH:D001930 Brain Injuries Progesterone 4.1715665606 15380490 15845082
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3315324884 17129689
MESH:D001943 Breast Neoplasms Lindane 2.3314688026
MESH:D001943 Breast Neoplasms Progesterone 2.3317614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3320435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3316166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.5616705839
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.5616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.561917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2716051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.0417460283
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.6014688030
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.446135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.4420889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 9.5616628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8111677210 16919318 17333356 16105132 15861022 17681005 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6412621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.649407595
MESH:D003092 Colitis Tretinoin 3.6217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9817141729 14669216
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 3.8717686920
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.879211117 10589399 14991402 17551590 8800419 9664655 9142499 16925845 9224671 9125849
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4712952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9318551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.4117187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.6121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D004487 Edema Staurosporine 6.958273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9512711302 11000095
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 20.6417686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 20.6418230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 20.6418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.7517692515
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.6116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.4015700306 16804899
MESH:D016889 Endometrial Neoplasms Tretinoin 7.4016569247
MESH:D004715 Endometriosis Progesterone 8.6616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.6610568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0520426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.6116938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.7315345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6015751030 16611131 16513791 16534752 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3320067830
MESH:D005355 Fibrosis Tretinoin 8.3317994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.8616452187
MESH:D005909 Glioblastoma Tretinoin 2.9517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 11.0320471113 17686920
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.0310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.0314991402 9664655
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 5.0013678655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Tretinoin 3.1416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006965 Hyperplasia Diethylstilbestrol 4.3512960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 10.9516002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.9516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3115869954
MESH:D007246 Infertility Diethylstilbestrol 4.2715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4317937319
MESH:D007249 Inflammation Progesterone 4.8315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8312878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.6616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.6617551590 15992940
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.3016705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.3016762066 15003126 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9717184923
MESH:D007938 Leukemia Tretinoin 2.7317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6219285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0617596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0919029980 17712046 17649720 19075265 16823087 15748426 16891316 19035177 19225113 19642359 17301526 16331271 16935935 17294898 17361223 16766008 16140955 17368321 12679006 9834237 17506722 17107899 16788101 17217047 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.2816248980 18397230
MESH:D008107 Liver Diseases Lindane 3.081715830
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 10.5016835634 18644402
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.507678174
MESH:D008113 Liver Neoplasms Diethylstilbestrol 10.5016712894 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.5016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.552876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2311884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0615166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.4316002989
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 6.2612807724
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.2617203775 11408345
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma Tretinoin 1.9316752155
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.6013678655
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0317596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.787678174 18551238
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 11.648820588
MESH:D009369 Neoplasms Diethylstilbestrol 11.6415313581
MESH:D009369 Neoplasms Lindane 11.6412807735 16818664
MESH:D009369 Neoplasms Tretinoin 11.6416594593 16946489
MESH:D009410 Nerve Degeneration Rotenone 3.8117356569 18619942 15790535
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.9011399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.9014600291
MESH:D009421 Nervous System Malformations Tretinoin 15.909125849
MESH:D009436 Neural Tube Defects Tretinoin 3.009142499
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3516049721
MESH:D010051 Ovarian Neoplasms Progesterone 4.8317393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8316936753
MESH:D010146 Pain Tretinoin 2.8316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010300 Parkinson Disease Rotenone 2.9511535288 18619942 15451049 18191903 11445065 19232380 19114014 16140633 16412576
MESH:D020734 Parkinsonian Disorders Rotenone 4.0015927086 18197244 15795934 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5815687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.2817184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2811399792 11896295 11118676 11222880
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.7615846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Lindane 3.7612661182 14688026
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2316919318 15861022
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0216283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0718551238
MESH:D012640 Seizures Lindane 6.077539098 15475178 12842176
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4216192470
MESH:D012878 Skin Neoplasms Tretinoin 5.4216467112
MESH:D013088 Spermatocele Diethylstilbestrol 11.4416002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4416709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1915862959 16503802
MESH:D020754 Spinocerebellar Ataxias marker/mechanism 18940801
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.7116051514
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0816049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.0816452187 16712894 17306315
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2310091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.2416175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.2416129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.1915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.1914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5316752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.3516513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
Pathway ID Pathway Name
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:05160 Hepatitis C
KEGG:03015 mRNA surveillance pathway
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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