AutismKB 2.0

Annotation Detail for LEPREL1


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Basic Information Top
Gene Symbol:LEPREL1 ( FLJ10718,MLAT4,P3H2 )
Gene Full Name: leprecan-like 1
Band: 3q28
Quick LinksEntrez ID:55214; OMIM: 610341; Uniprot ID:P3H2_HUMAN; ENSEMBL ID: ENSG00000090530; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
CHEMDEPENDENCY
smoking cessation
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of LEPREL1 mRNAincreases expression 19933214
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of LEPREL1 mRNAincreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LEPREL1 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in decreased expression of LEPREL1 mRNAdecreases expression 20106945
D002945 Cisplatin LEPREL1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LEPREL1 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 15322242 14514962
MESH:D058186 Acute Kidney Injury Cisplatin 4.2817670903 15814532 12690470
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.7420464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 4.7411798837 17638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.4114601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 1.8819526202 18382427
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 2.4417982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1216685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0120419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.0117066447 6189445 18337622
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.218697196 16354765 15668235 12621046 15340226
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Cisplatin 8.9515033597 12231392 12649298 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.9511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6616530937
MESH:D004938 Esophageal Neoplasms Cisplatin 7.6616481741 15464296 17638652 16785472 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Cyclosporine 9.9112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.9120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.9115464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.5819898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.6915464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9310048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 15340226 12621046
MESH:D006689 Hodgkin Disease Cisplatin 3.8816170182 16200630
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16959395 15340226 16354765 18606429
MESH:D006973 Hypertension Cyclosporine 5.2810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2818670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.6615464296
MESH:D007674 Kidney Diseases Cisplatin 6.7315190930 19839026 12231392 12649298 18289764
MESH:D007674 Kidney Diseases Cyclosporine 6.7318776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.3111231351
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6621137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5820064080 20464547 17053015 18816296 20869020 18569708 6695378 20135361 18520028
MESH:D008175 Lung Neoplasms Cisplatin 3.5817225452 11798837 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5811884234 19555203
MESH:D008545 Melanoma Cisplatin 2.5012883367 18505091 18176117 17023156 12393984 12374674 18332650 16432458 11135225 16248763 16809738 17761969 15577323
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.2415990972
MESH:D008654 Mesothelioma Cisplatin 3.3517638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6411141357
MESH:D009369 Neoplasms Cisplatin 5.6416773208
MESH:D009395 Nephritis, Interstitial Cisplatin 5.0115464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009447 Neuroblastoma Cisplatin 3.598761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.168761367
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9519769630 17225452 15464296 6897625
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0819003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.6915464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.8617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9217292933
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D051437 Renal Insufficiency Cisplatin 4.8215464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.8114601052
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.8615464296
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6020155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 2.6018396642 15958060 17522103
MESH:D013736 Testicular Neoplasms Cisplatin 4.9815464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5617053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.5617225452 12973940 15464296
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.5116803524
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014625 Vaginal Neoplasms Cisplatin 5.0315577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D014839 Vomiting Cisplatin 5.2411897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
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Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00126 - Vitamin C Antioxidants;Essential Vitamins;Free Radical Scavengers;Vitamins (Vitamin C);Vitamins
DB00139 - Ubicoenzyme Anti-Ulcer Agents;Dietary supplement;Micronutrient;Radiation-Protective Agents
DB00172 - L-Proline Dietary supplement;Micronutrient;Non-Essential Amino Acids
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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