AutismKB 2.0

Annotation Detail for LRRC1


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Basic Information Top
Gene Symbol:LRRC1 ( FLJ10775,FLJ11834,LANO,dJ523E19.1 )
Gene Full Name: leucine rich repeat containing 1
Band: 6p12.1
Quick LinksEntrez ID:55227; OMIM: 608195; Uniprot ID:LRRC1_HUMAN; ENSEMBL ID: ENSG00000137269; HGNC ID: 14307
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LRRC1 proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LRRC1 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of LRRC1 mRNAdecreases expression 15336504
D011374 Progesterone Progesterone results in increased expression of LRRC1 mRNAincreases expression 17404688
D014747 Vinblastine LRRC1 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.9517868700
MESH:D001930 Brain Injuries Progesterone 4.7415665606 15380490 15845082
MESH:D001943 Breast Neoplasms Progesterone 2.4116175315 15562024 17614352
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9821507988 12907637 12619106
MESH:D002292 Carcinoma, Renal Cell Vinblastine 3.921485588
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9620889678
MESH:D015179 Colorectal Neoplasms Vinblastine 2.7718802399
MESH:D003929 Diabetic Neuropathies Progesterone 4.9817187935
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2217692515
MESH:D004715 Endometriosis Progesterone 4.1116134523
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D006689 Hodgkin Disease Vinblastine 4.3518501091 18180244
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8915869954
MESH:D007249 Inflammation Progesterone 2.7515869954
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.459163691 18177683 2125692 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.948603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8814755239
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0711408345 17203775
MESH:D008545 Melanoma Vinblastine 2.9416432458 15577320 15577323 12374674 18505091 18176117 16809738 18332650 17761969 16248763
MESH:D009503 Neutropenia Vinblastine 4.9717378895
MESH:D010051 Ovarian Neoplasms Progesterone 2.6117393432 16525653
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9518045962
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.838532709
MESH:D013119 Spinal Cord Injuries Progesterone 4.8216503802 15862959
MESH:D014625 Vaginal Neoplasms Vinblastine 5.5315577323
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018