AutismKB 2.0

Annotation Detail for ASXL2


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Basic Information Top
Gene Symbol:ASXL2 ( ASXH2,DKFZp686C1968,FLJ10898,KIAA1685 )
Gene Full Name: additional sex combs like 2 (Drosophila)
Band: 2p23.3
Quick LinksEntrez ID:55252; OMIM: 612991; Uniprot ID:ASXL2_HUMAN; ENSEMBL ID: ENSG00000143970; HGNC ID: 23805
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ASXL2 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of ASXL2 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ASXL2 mRNAdecreases expression 19150397
20018196
D012643 Selenium Selenium results in decreased expression of ASXL2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3611798837 19825857
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1016206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.033084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0315553829 14691202 15073043 16217749 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D003092 Colitis Selenium 4.3417936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1012594235 14725611 19420014 18071297 11421492 11743745 19923254 12153990 15968718 19416960 10774834 17562736 17522070 11529661 19164858 12540782 2444490 12705907 15619225 19370779 17906064 16393943 11834606 16485898 14986274 12392966 11287661 16781746 19739265 10663392 10915739 11739529 16081117 11461765 16227642 18713872 16177239 14550746 19085960 12958197 16109766
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7320426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7312903497
MESH:D005234 Fatty Liver arsenic trioxide 3.7115073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006333 Heart Failure Selenium 3.2917162251
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007251 Influenza, Human Selenium 4.9216624496
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.3116518626
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1916968895 17050201 16467208 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4615336539 15748426 19075265 16331271 16330433 17217047 11161223 12018890 16966277 17107899 15622746 19642359 17869043 16112521 12679006 11468182 19225113 12712474 17649720 19035177 17712046 16891316 15213294 9834237 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008107 Liver Diseases Acetaminophen 1.7011587558 12969438 19014921 19784758 16610002 16611625 12587719 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4614682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9915318939
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008654 Mesothelioma Selenium 2.9215107826
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3819549372 15949261 11468182 14977855 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5019769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D010954 Plasmacytoma Selenium 5.6115087411
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2119131511
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6020435036 12973940 12845720 11780464
MESH:D014581 Urticaria Acetaminophen 3.4410982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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