AutismKB 2.0

Annotation Detail for PPP2R5C


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Basic Information Top
Gene Symbol:PPP2R5C ( B56G,MGC23064,PR61G )
Gene Full Name: protein phosphatase 2, regulatory subunit B', gamma
Band: 14q32.31
Quick LinksEntrez ID:5527; OMIM: 601645; Uniprot ID:2A5G_HUMAN; ENSEMBL ID: ENSG00000078304; HGNC ID: 9311
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04310Wnt signaling pathway
hsa04114Oocyte meiosis
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Hemostasis
Signaling in Immune system
No data
Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00021FGF signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PPP2R5C mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of PPP2R5C mRNAincreases expression 19774075
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PPP2R5C mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPP2R5C mRNAdecreases expression 19150397
20018196
D004112 Dimercaprol Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP2R5C mRNA]decreases expression|decreases reaction 16377760
D008727 Methotrexate PPP2R5C protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D009151 Mustard Gas Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP2R5C mRNA]decreases expression|decreases reaction 16377760
D009151 Mustard Gas Mustard Gas results in decreased expression of PPP2R5C mRNAdecreases expression 16377760
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PPP2R5C mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PPP2R5C mRNAincreases expression 17426115
18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.5812039119
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0320041841 18218290 18057881
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1417286800
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D001281 Atrial Fibrillation Amiodarone 4.0818651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.9019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9019483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3920146248 17474063
MESH:D001943 Breast Neoplasms Methotrexate 2.3916978400
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3517687719 10378619
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9615710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.6612039119 9562676
MESH:D003550 Cystic Fibrosis Methotrexate 4.4719747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003882 Dermatomyositis Methotrexate 5.4120191521
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0717522070 17906064 19085960 19923254 11421492 18713872 17562736 12540782 19416960 14550746 10774834 15619225 11834606 11743745 16227642 11529661 18071297 19164858 11461765 19420014 14986274 10663392 15968718 12705907 16081117 12392966 16485898 11287661 14725611 2444490 16781746 10915739 16177239 12594235 16393943 11739529 19370779 12153990 12958197 19739265 16109766
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.0718218290 15265979
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema Mustard Gas 7.6911428647 9260866 11428631 11402378
MESH:D004487 Edema pirinixic acid 7.6912083418
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D005234 Fatty Liver Amiodarone 8.6214986274
MESH:D005234 Fatty Liver pirinixic acid 8.6220131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006086 Graft vs Host Disease Methotrexate 5.4516518429
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly Amiodarone 9.6215265979
MESH:D006529 Hepatomegaly pirinixic acid 9.6219772884 18467677 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.128137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007037 Hypothyroidism Amiodarone 4.8218020914 17991464
MESH:D007249 Inflammation Mustard Gas 2.8917524151 11428647 11428620 16001271 8975870 9357497 9260866 11402378 11428631
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007805 Language Development Disorders Methotrexate 5.369562676
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell marker/mechanism 16038780
MESH:D008064 Lipidoses Amiodarone 3.6817567588 15342952
MESH:D008103 Liver Cirrhosis Methotrexate 3.8214986274
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6719784758 19460945 11587558 12969438 16610002 19014921 16611625 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6221137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.6220007298 16377806 15890375
MESH:D008133 Long QT Syndrome Amiodarone 3.7611989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 8.1312587719
MESH:D008171 Lung Diseases Mustard Gas 8.1318161513 18702808
MESH:D017563 Lung Diseases, Interstitial Amiodarone 12.8318516814
MESH:D017563 Lung Diseases, Interstitial Methotrexate 12.8318516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5820064080 20464547 6695378 18569708 20869020 18816296 20135361 18520028 17053015
MESH:D008175 Lung Neoplasms Mustard Gas 2.588781369 3148597
MESH:D008223 Lymphoma Methotrexate 4.1217352296
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D052016 Mucositis Methotrexate 5.6217488658
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009181 Mycoses Amiodarone 5.2817974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009503 Neutropenia Mustard Gas 4.2316761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D011565 Psoriasis Methotrexate 3.5017410198
MESH:D011658 Pulmonary Fibrosis Amiodarone 6.1112832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Mustard Gas 6.1117720292 17266442 10334151 17894541 17620002
MESH:D051437 Renal Insufficiency Methotrexate 5.0217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D012871 Skin Diseases Mustard Gas 2.7615451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4610029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
MESH:D013576 Syndactyly Methotrexate 5.329562676
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.1319731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.1718020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5311989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D014581 Urticaria Acetaminophen 3.2410982225
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:604 Hemostasis
KEGG:03015 mRNA surveillance pathway
KEGG:04114 Oocyte meiosis
REACT:11045 Signaling by Wnt
REACT:6900 Signaling in Immune system
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02506 - 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
DB06905 - (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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